Gene description for Sod2
Gene name	superoxide dismutase 2, mitochondrial
Gene symbol	Sod2
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Sod2
ExoCarta	ExoCarta_24787
Vesiclepedia	VP_24787
Entrez Gene	24787
UniProt	P07895
Sod2 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Sod2

Molecular Function     DNA binding GO:0003677 IDA     superoxide dismutase activity GO:0004784 IBA     superoxide dismutase activity GO:0004784 IDA     superoxide dismutase activity GO:0004784 ISO     superoxide dismutase activity GO:0004784 ISS     oxidoreductase activity GO:0016491 ISO     oxygen binding GO:0019825 IDA     enzyme binding GO:0019899 IPI     manganese ion binding GO:0030145 IBA     manganese ion binding GO:0030145 IDA     manganese ion binding GO:0030145 ISO     manganese ion binding GO:0030145 ISS     identical protein binding GO:0042802 IPI     identical protein binding GO:0042802 ISO Biological Process     response to reactive oxygen species GO:0000302 ISO     response to superoxide GO:0000303 ISO     response to superoxide GO:0000303 ISO     response to hypoxia GO:0001666 IEP     release of cytochrome c from mitochondria GO:0001836 ISO     liver development GO:0001889 ISO     detection of oxygen GO:0003032 ISO     acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0003069 ISO     regulation of transcription by RNA polymerase II GO:0006357 ISO     regulation of transcription by RNA polymerase II GO:0006357 ISO     regulation of transcription by RNA polymerase II GO:0006357 ISS     glutathione metabolic process GO:0006749 ISO     superoxide metabolic process GO:0006801 ISO     superoxide metabolic process GO:0006801 ISO     superoxide metabolic process GO:0006801 ISS     response to oxidative stress GO:0006979 IEP     response to oxidative stress GO:0006979 ISO     mitochondrion organization GO:0007005 ISO     heart development GO:0007507 ISO     sensory perception of sound GO:0007605 ISO     locomotory behavior GO:0007626 ISO     regulation of blood pressure GO:0008217 ISO     negative regulation of cell population proliferation GO:0008285 ISO     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 ISO     intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 ISO     apoptotic mitochondrial changes GO:0008637 ISO     response to xenobiotic stimulus GO:0009410 IDA     post-embryonic development GO:0009791 ISO     response to manganese ion GO:0010042 IEP     response to zinc ion GO:0010043 IEP     response to selenium ion GO:0010269 IEP     response to gamma radiation GO:0010332 ISO     positive regulation of hydrogen peroxide biosynthetic process GO:0010729 IMP     response to activity GO:0014823 IEP     response to activity GO:0014823 ISO     removal of superoxide radicals GO:0019430 IDA     removal of superoxide radicals GO:0019430 ISO     removal of superoxide radicals GO:0019430 ISO     respiratory electron transport chain GO:0022904 ISO     hemopoiesis GO:0030097 ISO     positive regulation of cell migration GO:0030335 ISO     response to nutrient levels GO:0031667 IDA     intracellular oxygen homeostasis GO:0032364 ISO     response to lipopolysaccharide GO:0032496 IEP     response to L-ascorbic acid GO:0033591 IEP     response to silicon dioxide GO:0034021 IEP     cellular response to oxidative stress GO:0034599 ISO     cellular response to oxidative stress GO:0034599 ISS     response to isolation stress GO:0035900 IEP     response to immobilization stress GO:0035902 IEP     vasodilation GO:0042311 ISO     response to hydrogen peroxide GO:0042542 IEP     response to hydrogen peroxide GO:0042542 ISO     superoxide anion generation GO:0042554 ISO     hydrogen peroxide metabolic process GO:0042743 IMP     negative regulation of apoptotic process GO:0043066 IMP     negative regulation of neuron apoptotic process GO:0043524 ISO     positive regulation of nitric oxide biosynthetic process GO:0045429 ISO     negative regulation of fat cell differentiation GO:0045599 ISO     response to cadmium ion GO:0046686 IEP     negative regulation of fibroblast proliferation GO:0048147 ISO     neuron development GO:0048666 ISO     response to axon injury GO:0048678 ISO     erythrophore differentiation GO:0048773 ISO     hydrogen peroxide biosynthetic process GO:0050665 IDA     regulation of catalytic activity GO:0050790 ISO     protein homotetramerization GO:0051289 ISO     response to electrical stimulus GO:0051602 IEP     regulation of mitochondrial membrane potential GO:0051881 ISO     response to hyperoxia GO:0055093 ISO     multicellular organismal-level iron ion homeostasis GO:0060586 ISO     response to magnetism GO:0071000 IEP     cellular response to ethanol GO:0071361 IEP     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 ISO     negative regulation of membrane hyperpolarization GO:1902631 IMP     negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 ISO     positive regulation of vascular associated smooth muscle cell apoptotic process GO:1905461 ISO     positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching GO:1905932 ISO Subcellular Localization     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 ISO     mitochondrial matrix GO:0005759 ISO     mitochondrial nucleoid GO:0042645 IDA