Gene description for Sord
Gene name sorbitol dehydrogenase
Gene symbol Sord
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Sord
ExoCarta ExoCarta_24788
Entrez Gene 24788
UniProt P27867  
 Sord identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Sord
Molecular Function
    identical protein binding GO:0042802 IDA
    L-iditol 2-dehydrogenase activity GO:0003939 ISO
    zinc ion binding GO:0008270 ISO
    NAD binding GO:0051287 ISO
Biological Process
    response to hormone GO:0009725 IDA
    L-xylitol catabolic process GO:0051160 ISO
    sorbitol metabolic process GO:0006060 ISO
    response to cadmium ion GO:0046686 IDA
    response to drug GO:0042493 IEP
    response to osmotic stress GO:0006970 IEP
    fructose biosynthetic process GO:0046370 ISO
    sperm motility GO:0030317 ISS
    response to nutrient levels GO:0031667 IEP
    sorbitol catabolic process GO:0006062 ISO
    response to copper ion GO:0046688 IDA
    oxidation-reduction process GO:0055114 IEA
    L-xylitol metabolic process GO:0051164 ISO
Subcellular Localization
    motile cilium GO:0031514 ISS
    membrane GO:0016020 ISO
    extracellular exosome GO:0070062 ISO
    mitochondrion GO:0005739 ISO
    mitochondrial membrane GO:0031966 IEA
    cellular_component GO:0005575 ND
 Experiment description of studies that identified Sord in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Sord
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sord is involved
PathwayEvidenceSource
Fructose biosynthesis IEA Reactome





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