Gene description for Hist1h2ba
Gene name histone cluster 1, H2ba
Gene symbol Hist1h2ba
Other names/aliases Th2b
Species Rattus norvegicus
 Database cross references - Hist1h2ba
ExoCarta ExoCarta_24829
Vesiclepedia VP_24829
Entrez Gene 24829
UniProt Q00729  
 Hist1h2ba identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Hist1h2ba
Molecular Function
    DNA binding GO:0003677 IDA
    DNA binding GO:0003677 IEA
    structural constituent of chromatin GO:0030527 IEA
    histone binding GO:0042393 IEA
    histone binding GO:0042393 ISO
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    chromatin organization GO:0006325 ISO
    nucleosome assembly GO:0006334 IEA
    nucleosome assembly GO:0006334 ISO
    nucleosome assembly GO:0006334 ISO
    nucleosome assembly GO:0006334 ISS
    nucleosome disassembly GO:0006337 IEA
    nucleosome disassembly GO:0006337 ISO
    nucleosome disassembly GO:0006337 ISS
    inflammatory response GO:0006954 IEA
    inflammatory response GO:0006954 ISO
    plasminogen activation GO:0031639 IEA
    plasminogen activation GO:0031639 ISO
    sperm DNA condensation GO:0035092 IEA
    sperm DNA condensation GO:0035092 ISO
    sperm DNA condensation GO:0035092 ISS
    chromosome organization GO:0051276 IEA
    chromosome organization GO:0051276 ISO
    mononuclear cell migration GO:0071674 IEA
    mononuclear cell migration GO:0071674 ISO
Subcellular Localization
    nucleosome GO:0000786 IEA
    nucleosome GO:0000786 ISO
    nucleosome GO:0000786 ISS
    female germ cell nucleus GO:0001674 IEA
    female germ cell nucleus GO:0001674 ISO
    nucleus GO:0005634 ISO
    cell surface GO:0009986 IEA
    cell surface GO:0009986 ISO
 Experiment description of studies that identified Hist1h2ba in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Hist1h2ba
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hist1h2ba is involved
PathwayEvidenceSource
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 IEA Reactome
Assembly of the ORC complex at the origin of replication IEA Reactome
Assembly of the pre-replicative complex IEA Reactome
B-WICH complex positively regulates rRNA expression IEA Reactome
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Cellular Senescence IEA Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
Chromosome Maintenance IEA Reactome
Cleavage of the damaged purine IEA Reactome
Condensation of Prophase Chromosomes IEA Reactome
Deposition of new CENPA-containing nucleosomes at the centromere IEA Reactome
Depurination IEA Reactome
DNA Damage/Telomere Stress Induced Senescence IEA Reactome
DNA Double Strand Break Response IEA Reactome
DNA Double-Strand Break Repair IEA Reactome
DNA Repair IEA Reactome
DNA Replication IEA Reactome
DNA Replication Pre-Initiation IEA Reactome
E3 ubiquitin ligases ubiquitinate target proteins IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
ESR-mediated signaling IEA Reactome
Estrogen-dependent gene expression IEA Reactome
G2/M Checkpoints IEA Reactome
G2/M DNA damage checkpoint IEA Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA IEA Reactome
Generic Transcription Pathway IEA Reactome
HATs acetylate histones IEA Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) IEA Reactome
Homology Directed Repair IEA Reactome
M Phase IEA Reactome
Metabolism of proteins IEA Reactome
Mitotic Prophase IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
Nonhomologous End-Joining (NHEJ) IEA Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Nucleosome assembly IEA Reactome
Oxidative Stress Induced Senescence IEA Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
Post-translational protein modification IEA Reactome
PRC2 methylates histones and DNA IEA Reactome
Processing of DNA double-strand break ends IEA Reactome
Protein ubiquitination IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks IEA Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases activate PKNs IEA Reactome
RNA Polymerase I Promoter Clearance IEA Reactome
RNA Polymerase I Promoter Escape IEA Reactome
RNA Polymerase I Promoter Opening IEA Reactome
RNA Polymerase I Transcription IEA Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) IEA Reactome
Signal Transduction IEA Reactome
Signaling by Nuclear Receptors IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
SIRT1 negatively regulates rRNA expression IEA Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by small RNAs IEA Reactome





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