Gene description for Clu
Gene name	clusterin
Gene symbol	Clu
Other names/aliases	APOJ CLI DAG RATTRPM2B SGP-2 SGP2 SP-40 SP40 TRPM-2 TRPM2B Trpm2 Trpmb
Species	Rattus norvegicus
Database cross references - Clu
ExoCarta	ExoCarta_24854
Vesiclepedia	VP_24854
Entrez Gene	24854
UniProt	P05371
Clu identified in sEVs derived from the following tissue/cell type
Hepatocytes	19367702
Reticulocytes	21828046

Gene ontology annotations for Clu

Molecular Function     amyloid-beta binding GO:0001540 IEA     amyloid-beta binding GO:0001540 ISO     signaling receptor binding GO:0005102 ISO     protein binding GO:0005515 IPI     ATP hydrolysis activity GO:0016887 ISO     ATP hydrolysis activity GO:0016887 ISS     ubiquitin protein ligase binding GO:0031625 IEA     ubiquitin protein ligase binding GO:0031625 ISO     ubiquitin protein ligase binding GO:0031625 ISS     protein-containing complex binding GO:0044877 IEA     protein-containing complex binding GO:0044877 ISO     receptor ligand activity GO:0048018 IEA     receptor ligand activity GO:0048018 ISO     tau protein binding GO:0048156 IEA     tau protein binding GO:0048156 ISO     low-density lipoprotein particle receptor binding GO:0050750 IEA     low-density lipoprotein particle receptor binding GO:0050750 ISO     unfolded protein binding GO:0051082 IEA     unfolded protein binding GO:0051082 ISO     unfolded protein binding GO:0051082 ISS     misfolded protein binding GO:0051787 IBA     misfolded protein binding GO:0051787 IEA     misfolded protein binding GO:0051787 ISO     misfolded protein binding GO:0051787 ISS     protein carrier chaperone GO:0140597 IEA     protein carrier chaperone GO:0140597 ISO Biological Process     cell morphogenesis GO:0000902 IEA     cell morphogenesis GO:0000902 ISO     cell morphogenesis GO:0000902 ISS     microglial cell activation GO:0001774 IEA     microglial cell activation GO:0001774 ISO     microglial cell activation GO:0001774 ISS     immune complex clearance GO:0002434 IEA     immune complex clearance GO:0002434 ISO     immune complex clearance GO:0002434 ISS     signal transduction GO:0007165 IEA     spermatogenesis GO:0007283 IEA     positive regulation of cell population proliferation GO:0008284 IMP     response to light stimulus GO:0009416 IEP     response to virus GO:0009615 IEA     response to virus GO:0009615 ISO     positive regulation of gene expression GO:0010628 IGI     protein import GO:0017038 IEA     protein import GO:0017038 ISO     protein import GO:0017038 ISS     endocrine pancreas development GO:0031018 IMP     negative regulation of protein-containing complex assembly GO:0031333 IEA     negative regulation of protein-containing complex assembly GO:0031333 ISO     negative regulation of protein-containing complex assembly GO:0031333 ISS     positive regulation of protein-containing complex assembly GO:0031334 IEA     positive regulation of protein-containing complex assembly GO:0031334 ISO     central nervous system myelin maintenance GO:0032286 IEA     central nervous system myelin maintenance GO:0032286 ISO     central nervous system myelin maintenance GO:0032286 ISS     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IBA     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IEA     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISO     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS     positive regulation of tumor necrosis factor production GO:0032760 IEA     positive regulation of tumor necrosis factor production GO:0032760 ISO     positive regulation of tumor necrosis factor production GO:0032760 ISS     response to potassium ion GO:0035864 IEP     regulation of cell population proliferation GO:0042127 IEA     regulation of cell population proliferation GO:0042127 ISO     regulation of cell population proliferation GO:0042127 ISS     regulation of apoptotic process GO:0042981 IBA     positive regulation of apoptotic process GO:0043065 IEA     positive regulation of apoptotic process GO:0043065 ISO     positive regulation of apoptotic process GO:0043065 ISS     negative regulation of apoptotic process GO:0043066 IMP     negative regulation of neuron apoptotic process GO:0043524 IGI     estrous cycle GO:0044849 IEP     positive regulation of nitric oxide biosynthetic process GO:0045429 IEA     positive regulation of nitric oxide biosynthetic process GO:0045429 ISO     positive regulation of nitric oxide biosynthetic process GO:0045429 ISS     positive regulation of cell differentiation GO:0045597 IMP     positive regulation of receptor-mediated endocytosis GO:0048260 IEA     positive regulation of receptor-mediated endocytosis GO:0048260 ISO     positive regulation of receptor-mediated endocytosis GO:0048260 ISS     neuron projection morphogenesis GO:0048812 IMP     protein stabilization GO:0050821 IDA     protein stabilization GO:0050821 IEA     protein stabilization GO:0050821 ISO     protein stabilization GO:0050821 ISS     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS     chaperone-mediated protein complex assembly GO:0051131 IEA     chaperone-mediated protein complex assembly GO:0051131 ISO     chaperone-mediated protein complex assembly GO:0051131 ISS     response to misfolded protein GO:0051788 IEA     response to misfolded protein GO:0051788 ISO     response to misfolded protein GO:0051788 ISS     chaperone-mediated protein folding GO:0061077 IEA     chaperone-mediated protein folding GO:0061077 ISO     chaperone-mediated protein folding GO:0061077 ISS     microglial cell proliferation GO:0061518 IEA     microglial cell proliferation GO:0061518 ISO     microglial cell proliferation GO:0061518 ISS     protein targeting to lysosome involved in chaperone-mediated autophagy GO:0061740 IEA     protein targeting to lysosome involved in chaperone-mediated autophagy GO:0061740 ISO     cellular response to growth factor stimulus GO:0071363 IEP     intrinsic apoptotic signaling pathway GO:0097193 ISO     intrinsic apoptotic signaling pathway GO:0097193 ISS     amyloid-beta clearance GO:0097242 IEA     amyloid-beta clearance GO:0097242 ISO     regulation of amyloid-beta clearance GO:1900221 IEA     regulation of amyloid-beta clearance GO:1900221 ISO     regulation of amyloid-beta clearance GO:1900221 ISS     positive regulation of amyloid-beta formation GO:1902004 IEA     positive regulation of amyloid-beta formation GO:1902004 ISO     positive regulation of amyloid-beta formation GO:1902004 ISS     negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 IEA     negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 ISO     negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 ISS     negative regulation of amyloid-beta formation GO:1902430 IEA     negative regulation of amyloid-beta formation GO:1902430 ISO     negative regulation of amyloid-beta formation GO:1902430 ISS     regulation of neuronal signal transduction GO:1902847 IEA     regulation of neuronal signal transduction GO:1902847 ISO     regulation of neuronal signal transduction GO:1902847 ISS     positive regulation of neurofibrillary tangle assembly GO:1902998 IEA     positive regulation of neurofibrillary tangle assembly GO:1902998 ISO     positive regulation of neurofibrillary tangle assembly GO:1902998 ISS     negative regulation of response to endoplasmic reticulum stress GO:1903573 IEA     negative regulation of response to endoplasmic reticulum stress GO:1903573 ISO     negative regulation of amyloid fibril formation GO:1905907 IEA     negative regulation of amyloid fibril formation GO:1905907 ISO     negative regulation of amyloid fibril formation GO:1905907 ISS     positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 ISO     positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 ISS     positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISO     positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISS Subcellular Localization     extracellular region GO:0005576 IEA     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     extracellular space GO:0005615 ISO     extracellular space GO:0005615 ISS     nucleus GO:0005634 IBA     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     mitochondrion GO:0005739 ISO     mitochondrion GO:0005739 ISS     mitochondrial inner membrane GO:0005743 IEA     mitochondrial inner membrane GO:0005743 ISO     mitochondrial inner membrane GO:0005743 ISS     endoplasmic reticulum GO:0005783 IEA     Golgi apparatus GO:0005794 ISO     cytosol GO:0005829 IDA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISS     cytoskeleton GO:0005856 IEA     cytoskeleton GO:0005856 ISO     cell surface GO:0009986 IEA     cell surface GO:0009986 ISO     membrane GO:0016020 ISO     aggresome GO:0016235 IDA     growth cone GO:0030426 IDA     mitochondrial membrane GO:0031966 IEA     protein-containing complex GO:0032991 ISO     spherical high-density lipoprotein particle GO:0034366 IEA     spherical high-density lipoprotein particle GO:0034366 ISO     spherical high-density lipoprotein particle GO:0034366 ISS     chromaffin granule GO:0042583 IEA     intracellular membrane-bounded organelle GO:0043231 ISO     synapse GO:0045202 IEA     synapse GO:0045202 ISO     perinuclear region of cytoplasm GO:0048471 IDA     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     collagen-containing extracellular matrix GO:0062023 ISS     cell periphery GO:0071944 IEA     cell periphery GO:0071944 ISO     neurofibrillary tangle GO:0097418 IEA     neurofibrillary tangle GO:0097418 ISO     neurofibrillary tangle GO:0097418 ISS     apical dendrite GO:0097440 IEA     apical dendrite GO:0097440 ISO     apical dendrite GO:0097440 ISS     perinuclear endoplasmic reticulum lumen GO:0099020 IEA     perinuclear endoplasmic reticulum lumen GO:0099020 ISO     perinuclear endoplasmic reticulum lumen GO:0099020 ISS