Gene description for Ugt1a1
Gene name UDP glucuronosyltransferase 1 family, polypeptide A1
Gene symbol Ugt1a1
Other names/aliases UDPGT 1-1
Udpgt
Ugt1
Species Rattus norvegicus
 Database cross references - Ugt1a1
ExoCarta ExoCarta_24861
Entrez Gene 24861
UniProt Q64550  
 Ugt1a1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Ugt1a1
Molecular Function
    enzyme inhibitor activity GO:0004857 IEA
    enzyme binding GO:0019899 IDA
    transferase activity, transferring hexosyl groups GO:0016758 IEA
    retinoic acid binding GO:0001972 IEA
    protein heterodimerization activity GO:0046982 IEA
    protein homodimerization activity GO:0042803 IEA
    steroid binding GO:0005496 IEA
    glucuronosyltransferase activity GO:0015020 IDA
Biological Process
    response to ethanol GO:0045471 IEP
    response to organic substance GO:0010033 IMP
    organ regeneration GO:0031100 IEP
    metabolic process GO:0008152 IEA
    biphenyl catabolic process GO:0070980 IDA
    cellular response to glucocorticoid stimulus GO:0071385 IEP
    response to starvation GO:0042594 IEP
    negative regulation of catalytic activity GO:0043086 IEA
    flavonoid glucuronidation GO:0052696 IBA
    flavone metabolic process GO:0051552 IEA
    response to organic cyclic compound GO:0014070 IEP
    response to steroid hormone GO:0048545 IEP
    response to nutrient GO:0007584 IEP
    xenobiotic glucuronidation GO:0052697 IBA
    response to glucocorticoid GO:0051384 IEP
    response to lipopolysaccharide GO:0032496 IEP
    acute-phase response GO:0006953 IEP
    cellular response to ethanol GO:0071361 IEP
    liver development GO:0001889 IEP
    bilirubin conjugation GO:0006789 TAS
    response to drug GO:0042493 IEP
    negative regulation of cellular glucuronidation GO:2001030 IEA
    flavonoid biosynthetic process GO:0009813 IBA
    cellular response to hormone stimulus GO:0032870 IEP
Subcellular Localization
    integral component of plasma membrane GO:0005887 IEA
    endoplasmic reticulum membrane GO:0005789 IBA
    intracellular membrane-bounded organelle GO:0043231 IDA
    cytochrome complex GO:0070069 IDA
    endoplasmic reticulum GO:0005783 IDA
 Experiment description of studies that identified Ugt1a1 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Ugt1a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ugt1a1 is involved
PathwayEvidenceSource
Glucuronidation IEA Reactome
Heme degradation IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here