Gene description for Abcb4
Gene name	ATP-binding cassette, subfamily B (MDR/TAP), member 4
Gene symbol	Abcb4
Other names/aliases	Mdr2 Pgy3
Species	Rattus norvegicus
Database cross references - Abcb4
ExoCarta	ExoCarta_24891
Vesiclepedia	VP_24891
Entrez Gene	24891
UniProt	Q08201
Abcb4 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Abcb4

Molecular Function     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ATP hydrolysis activity GO:0016887 IEA     ATPase-coupled transmembrane transporter activity GO:0042626 IBA     ATPase-coupled transmembrane transporter activity GO:0042626 ISO     ATPase-coupled transmembrane transporter activity GO:0042626 ISS     phosphatidylcholine floppase activity GO:0090554 IBA     phosphatidylcholine floppase activity GO:0090554 IEA     phosphatidylcholine floppase activity GO:0090554 ISO     phosphatidylcholine floppase activity GO:0090554 ISS     ceramide floppase activity GO:0099038 ISO     ABC-type transporter activity GO:0140359 IEA Biological Process     xenobiotic transmembrane transport GO:0006855 ISO     response to xenobiotic stimulus GO:0009410 IEP     positive regulation of cholesterol transport GO:0032376 IEA     positive regulation of cholesterol transport GO:0032376 ISO     positive regulation of cholesterol transport GO:0032376 ISS     bile acid secretion GO:0032782 IEA     bile acid secretion GO:0032782 ISO     bile acid secretion GO:0032782 ISS     phospholipid translocation GO:0045332 IBA     phospholipid translocation GO:0045332 IEA     phospholipid translocation GO:0045332 ISO     response to glucocorticoid GO:0051384 IEP     transmembrane transport GO:0055085 IEA     lipid homeostasis GO:0055088 IEA     lipid homeostasis GO:0055088 ISO     lipid homeostasis GO:0055088 ISS     positive regulation of phospholipid translocation GO:0061092 IEA     positive regulation of phospholipid translocation GO:0061092 ISO     positive regulation of phospholipid translocation GO:0061092 ISS     ceramide translocation GO:0099040 ISO     response to fenofibrate GO:1901557 IEA     response to fenofibrate GO:1901557 ISO     response to fenofibrate GO:1901557 ISS     cellular response to bile acid GO:1903413 IEA     cellular response to bile acid GO:1903413 ISO     cellular response to bile acid GO:1903413 ISS     positive regulation of phospholipid transport GO:2001140 ISO     positive regulation of phospholipid transport GO:2001140 ISS Subcellular Localization     Golgi membrane GO:0000139 IDA     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     plasma membrane GO:0005886 ISO     focal adhesion GO:0005925 IEA     focal adhesion GO:0005925 ISO     membrane GO:0016020 ISO     apical plasma membrane GO:0016324 IBA     apical plasma membrane GO:0016324 IDA     apical plasma membrane GO:0016324 IEA     apical plasma membrane GO:0016324 ISO     clathrin-coated vesicle GO:0030136 IEA     membrane raft GO:0045121 IEA     intercellular canaliculus GO:0046581 IEA     intercellular canaliculus GO:0046581 ISO