Gene description for Abcb4
Gene name ATP-binding cassette, subfamily B (MDR/TAP), member 4
Gene symbol Abcb4
Other names/aliases Mdr2
Pgy3
Species Rattus norvegicus
 Database cross references - Abcb4
ExoCarta ExoCarta_24891
Entrez Gene 24891
UniProt Q08201  
 Abcb4 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Abcb4
Molecular Function
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    ATPase activity, coupled to transmembrane movement of substances GO:0042626 IEA
    xenobiotic-transporting ATPase activity GO:0008559 IEA
Biological Process
    response to glucocorticoid GO:0051384 IEP
    xenobiotic transport GO:0042908 IEA
    drug transmembrane transport GO:0006855 IEA
    response to drug GO:0042493 IEP
    metabolic process GO:0008152 IEA
    transmembrane transport GO:0055085 IEA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    apical plasma membrane GO:0016324 IDA
    membrane GO:0016020 ISO
    Golgi membrane GO:0000139 IDA
    integral component of membrane GO:0016021 IEA
    intercellular canaliculus GO:0046581 ISO
 Experiment description of studies that identified Abcb4 in exosomes
1
Experiment ID 90
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSC70|HSP90|TSG101
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Abcb4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Abcb4 is involved
No pathways found





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