Gene description for Cyp2a2
Gene name cytochrome P450, family 2, subfamily a, polypeptide 2
Gene symbol Cyp2a2
Other names/aliases CYP2A21
RATCYP2A21
Species Rattus norvegicus
 Database cross references - Cyp2a2
ExoCarta ExoCarta_24895
Entrez Gene 24895
UniProt P15149  
 Cyp2a2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Cyp2a2
Molecular Function
    oxygen binding GO:0019825 IBA
    steroid hydroxylase activity GO:0008395 TAS
    aromatase activity GO:0070330 IEA
    arachidonic acid epoxygenase activity GO:0008392 IBA
    heme binding GO:0020037 IBA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 IBA
    iron ion binding GO:0005506 IEA
Biological Process
    coumarin metabolic process GO:0009804 IBA
    xenobiotic metabolic process GO:0006805 IBA
    epoxygenase P450 pathway GO:0019373 IBA
    oxidation-reduction process GO:0055114 IBA
    exogenous drug catabolic process GO:0042738 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
    intracellular membrane-bounded organelle GO:0043231 IBA
 Experiment description of studies that identified Cyp2a2 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Cyp2a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cyp2a2 is involved
No pathways found





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