Gene description for Gnas
Gene name	GNAS complex locus
Gene symbol	Gnas
Other names/aliases	Gnas1 Gnpas Nesp55
Species	Rattus norvegicus
Database cross references - Gnas
ExoCarta	ExoCarta_24896
Vesiclepedia	VP_24896
Entrez Gene	24896
UniProt	P63095   Q792G6
Gnas identified in exosomes derived from the following tissue/cell type
Hepatocytes	19367702
Urine	20535238

Gene ontology annotations for Gnas

Molecular Function     protein domain specific binding GO:0019904 IPI     D1 dopamine receptor binding GO:0031748 IPI     ionotropic glutamate receptor binding GO:0035255 IPI     metal ion binding GO:0046872 IEA     insulin-like growth factor receptor binding GO:0005159 IPI     G-protein beta/gamma-subunit complex binding GO:0031683 IEA     signal transducer activity GO:0004871 ISO     GTPase activity GO:0003924 IEA     G-protein beta-subunit binding GO:0031681 IDA     corticotropin-releasing hormone receptor 1 binding GO:0051430 IPI     GTP binding GO:0005525 TAS     G-protein alpha-subunit binding GO:0001965 IPI     alpha-tubulin binding GO:0043014 IDA     protein binding GO:0005515 IPI     mu-type opioid receptor binding GO:0031852 IPI     beta-2 adrenergic receptor binding GO:0031698 IPI Biological Process     skin development GO:0043588 ISO     adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 ISS     positive regulation of osteoblast differentiation GO:0045669 ISO     metabolic process GO:0008152 IEA     calcium ion homeostasis GO:0055074 IMP     post-embryonic body morphogenesis GO:0040032 ISO     energy reserve metabolic process GO:0006112 ISO     endochondral ossification GO:0001958 ISO     negative regulation of multicellular organism growth GO:0040015 ISO     multicellular organism growth GO:0035264 ISO     cellular response to catecholamine stimulus GO:0071870 IDA     adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 ISO     cellular response to prostaglandin E stimulus GO:0071380 IDA     negative regulation of renal sodium excretion GO:0035814 IMP     G-protein coupled receptor signaling pathway GO:0007186 IMP     skeletal system development GO:0001501 ISO     cartilage development GO:0051216 ISO     positive regulation of cAMP biosynthetic process GO:0030819 ISO     platelet aggregation GO:0070527 ISO     response to drug GO:0042493 ISO     positive regulation of osteoclast differentiation GO:0045672 ISO     bone development GO:0060348 ISO     cognition GO:0050890 ISO     embryonic hindlimb morphogenesis GO:0035116 ISO     tissue homeostasis GO:0001894 ISO     response to parathyroid hormone GO:0071107 ISO     positive regulation of protein phosphorylation GO:0001934 IMP     genetic imprinting GO:0071514 ISO     regulation of signal transduction GO:0009966 ISO     developmental growth GO:0048589 ISO     adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 ISO     positive regulation of GTPase activity GO:0043547 ISS     regulation of transcription from RNA polymerase II promoter GO:0006357 IMP     negative regulation of blood pressure GO:0045776 IMP     post-embryonic development GO:0009791 ISO     hair follicle placode formation GO:0060789 ISO     positive regulation of sodium ion transport GO:0010765 IMP     sensory perception of chemical stimulus GO:0007606 IBA     embryonic cranial skeleton morphogenesis GO:0048701 ISO     DNA methylation GO:0006306 ISO     positive regulation of cAMP-mediated signaling GO:0043950 ISS Subcellular Localization     extracellular exosome GO:0070062 ISO     dendrite GO:0030425 ISO     ruffle GO:0001726 IDA     vesicle GO:0031982 IDA     synaptic vesicle GO:0008021 IEA     cytosol GO:0005829 ISO     membrane raft GO:0045121 IDA     heterotrimeric G-protein complex GO:0005834 IDA     perinuclear region of cytoplasm GO:0048471 ISO     intrinsic component of membrane GO:0031224 ISO     cytoplasm GO:0005737 ISO     membrane GO:0016020 ISO     nucleus GO:0005634 ISO     sarcolemma GO:0042383 IDA     extracellular region GO:0005576 IEA     endosome GO:0005768 IDA     cell junction GO:0030054 IEA     plasma membrane GO:0005886 TAS     trans-Golgi network membrane GO:0032588 ISO