Gene description for Atp7a
Gene name	ATPase, Cu++ transporting, alpha polypeptide
Gene symbol	Atp7a
Other names/aliases	Mnk
Species	Rattus norvegicus
Database cross references - Atp7a
ExoCarta	ExoCarta_24941
Vesiclepedia	VP_24941
Entrez Gene	24941
UniProt	P70705
Atp7a identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Atp7a

Molecular Function     copper ion transmembrane transporter activity GO:0005375 ISO     copper ion binding GO:0005507 IBA     copper ion binding GO:0005507 ISO     ATP binding GO:0005524 ISO     ATP binding GO:0005524 ISS     superoxide dismutase copper chaperone activity GO:0016532 ISO     ATP hydrolysis activity GO:0016887 IEA     small GTPase binding GO:0031267 IPI     copper-dependent protein binding GO:0032767 ISO     copper-dependent protein binding GO:0032767 ISS     P-type divalent copper transporter activity GO:0043682 IBA     P-type divalent copper transporter activity GO:0043682 ISO     metal ion binding GO:0046872 IEA     protein-folding chaperone binding GO:0051087 IPI     P-type monovalent copper transporter activity GO:0140581 ISO     P-type monovalent copper transporter activity GO:0140581 ISS     cuprous ion binding GO:1903136 ISO     cuprous ion binding GO:1903136 ISS Biological Process     blood vessel development GO:0001568 ISO     in utero embryonic development GO:0001701 IEP     release of cytochrome c from mitochondria GO:0001836 ISO     liver development GO:0001889 IEP     blood vessel remodeling GO:0001974 ISO     regulation of oxidative phosphorylation GO:0002082 ISO     tryptophan metabolic process GO:0006568 ISO     tyrosine metabolic process GO:0006570 ISO     catecholamine metabolic process GO:0006584 ISO     catecholamine metabolic process GO:0006584 ISO     copper ion transport GO:0006825 ISO     copper ion transport GO:0006825 ISO     intracellular copper ion homeostasis GO:0006878 IBA     intracellular copper ion homeostasis GO:0006878 ISO     intracellular copper ion homeostasis GO:0006878 ISO     intracellular copper ion homeostasis GO:0006878 ISS     mitochondrion organization GO:0007005 ISO     female pregnancy GO:0007565 IEP     lactation GO:0007595 IEP     locomotory behavior GO:0007626 ISO     response to iron(III) ion GO:0010041 IEP     response to manganese ion GO:0010042 IDA     response to manganese ion GO:0010042 IEP     response to zinc ion GO:0010043 IEP     detoxification of copper ion GO:0010273 ISO     response to lead ion GO:0010288 IEP     regulation of gene expression GO:0010468 ISO     positive regulation of lamellipodium assembly GO:0010592 IMP     copper ion import GO:0015677 IBA     copper ion import GO:0015677 ISO     peptidyl-lysine modification GO:0018205 ISO     removal of superoxide radicals GO:0019430 ISO     cerebellar Purkinje cell differentiation GO:0021702 ISO     pyramidal neuron development GO:0021860 ISO     central nervous system neuron development GO:0021954 ISO     extracellular matrix organization GO:0030198 ISO     collagen fibril organization GO:0030199 ISO     hair follicle morphogenesis GO:0031069 ISO     positive regulation of tyrosinase activity GO:0032773 ISO     positive regulation of tyrosinase activity GO:0032773 ISS     negative regulation of iron ion transmembrane transport GO:0034760 IMP     hindlimb morphogenesis GO:0035137 ISO     cellular response to platelet-derived growth factor stimulus GO:0036120 IMP     T-helper cell differentiation GO:0042093 ISO     epinephrine metabolic process GO:0042414 ISO     norepinephrine metabolic process GO:0042415 ISO     dopamine metabolic process GO:0042417 ISO     norepinephrine biosynthetic process GO:0042421 ISO     serotonin metabolic process GO:0042428 ISO     positive regulation of catalytic activity GO:0043085 ISO     pigmentation GO:0043473 ISO     negative regulation of neuron apoptotic process GO:0043524 ISO     skin development GO:0043588 ISO     positive regulation of cell size GO:0045793 IMP     negative regulation of catecholamine metabolic process GO:0045914 ISO     ATP metabolic process GO:0046034 ISO     response to copper ion GO:0046688 IDA     response to copper ion GO:0046688 IEP     positive regulation of melanin biosynthetic process GO:0048023 ISO     positive regulation of melanin biosynthetic process GO:0048023 ISS     elastic fiber assembly GO:0048251 ISO     lung alveolus development GO:0048286 ISO     neuron projection morphogenesis GO:0048812 ISO     dendrite morphogenesis GO:0048813 ISO     positive regulation of epithelial cell proliferation GO:0050679 IMP     cartilage development GO:0051216 ISO     neuron apoptotic process GO:0051402 ISO     elastin biosynthetic process GO:0051542 ISO     establishment of localization in cell GO:0051649 ISO     copper ion export GO:0060003 IBA     copper ion export GO:0060003 IMP     copper ion export GO:0060003 ISO     copper ion export GO:0060003 ISO     copper ion export GO:0060003 ISS     neuron cellular homeostasis GO:0070050 ISO     cellular response to amino acid stimulus GO:0071230 IMP     cellular response to antibiotic GO:0071236 IEP     cellular response to cadmium ion GO:0071276 IEP     cellular response to cobalt ion GO:0071279 IEP     cellular response to copper ion GO:0071280 IDA     cellular response to copper ion GO:0071280 IEP     cellular response to iron ion GO:0071281 IEP     cellular response to lead ion GO:0071284 IEP     cellular response to hypoxia GO:0071456 IEP     positive regulation of superoxide dismutase activity GO:1901671 ISO     positive regulation of response to wounding GO:1903036 IMP     positive regulation of vascular associated smooth muscle cell migration GO:1904754 IMP     regulation of cytochrome-c oxidase activity GO:1904959 IMP     positive regulation of cytochrome-c oxidase activity GO:1904960 ISO Subcellular Localization     late endosome GO:0005770 IDA     late endosome GO:0005770 ISO     endoplasmic reticulum GO:0005783 ISO     Golgi apparatus GO:0005794 IDA     Golgi apparatus GO:0005794 ISO     trans-Golgi network GO:0005802 IBA     trans-Golgi network GO:0005802 IDA     trans-Golgi network GO:0005802 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     microvillus GO:0005902 IDA     postsynaptic density GO:0014069 IEA     membrane GO:0016020 IDA     membrane GO:0016020 IEA     membrane GO:0016020 ISO     basolateral plasma membrane GO:0016323 IDA     basolateral plasma membrane GO:0016323 ISO     apical plasma membrane GO:0016324 IDA     trans-Golgi network transport vesicle GO:0030140 ISO     secretory granule GO:0030141 IDA     axon GO:0030424 IDA     dendrite GO:0030425 IDA     cell leading edge GO:0031252 IDA     cytoplasmic vesicle GO:0031410 ISO     brush border membrane GO:0031526 IDA     early endosome membrane GO:0031901 ISO     early endosome membrane GO:0031901 ISS     trans-Golgi network membrane GO:0032588 IDA     trans-Golgi network membrane GO:0032588 ISO     melanosome membrane GO:0033162 ISO     melanosome membrane GO:0033162 ISS     neuron projection GO:0043005 ISO     neuronal cell body GO:0043025 ISO     perikaryon GO:0043204 IDA     perinuclear region of cytoplasm GO:0048471 IDA     perinuclear region of cytoplasm GO:0048471 ISO