Gene description for Cth
Gene name cystathionine gamma-lyase
Gene symbol Cth
Other names/aliases H
Species Rattus norvegicus
 Database cross references - Cth
ExoCarta ExoCarta_24962
Entrez Gene 24962
UniProt P18757  
 Cth identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
Urine 20535238    
 Gene ontology annotations for Cth
Molecular Function
    calmodulin binding GO:0005516 IEA
    L-cysteine desulfhydrase activity GO:0080146 IEA
    cystathionine beta-lyase activity GO:0004121 IDA
    L-cystine L-cysteine-lyase (deaminating) GO:0044540 ISS
    pyridoxal phosphate binding GO:0030170 TAS
    cystathionine gamma-lyase activity GO:0004123 ISS
Biological Process
    negative regulation of cell proliferation GO:0008285 IMP
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISS
    cysteine biosynthetic process GO:0019344 ISS
    protein homotetramerization GO:0051289 ISO
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS
    transsulfuration GO:0019346 TAS
    negative regulation of apoptotic signaling pathway GO:2001234 ISO
    homocysteine metabolic process GO:0050667 IDA
    protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine GO:0018272 ISS
    glutathione metabolic process GO:0006749 IMP
    protein sulfhydration GO:0044524 ISS
    hydrogen sulfide biosynthetic process GO:0070814 ISS
    negative regulation of apoptotic process GO:0043066 ISS
    negative regulation of cell growth GO:0030308 IMP
Subcellular Localization
    nucleus GO:0005634 ISO
    cellular_component GO:0005575 ND
    cytoplasm GO:0005737 ISO
    nucleoplasm GO:0005654 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Cth in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
2
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cth
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cth is involved
No pathways found





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