Gene description for Hspa1l
Gene name heat shock protein 1-like
Gene symbol Hspa1l
Other names/aliases Hsp70-3
Species Rattus norvegicus
 Database cross references - Hspa1l
ExoCarta ExoCarta_24963
Entrez Gene 24963
UniProt P55063  
 Hspa1l identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Hspa1l
Molecular Function
    ATP binding GO:0005524 IEA
    unfolded protein binding GO:0051082 ISO
    ubiquitin protein ligase binding GO:0031625 ISO
    molecular_function GO:0003674 ND
Biological Process
    positive regulation of protein targeting to mitochondrion GO:1903955 ISO
    protein refolding GO:0042026 ISO
    binding of sperm to zona pellucida GO:0007339 ISO
    biological_process GO:0008150 ND
Subcellular Localization
    COP9 signalosome GO:0008180 ISO
    cell body GO:0044297 ISO
    zona pellucida receptor complex GO:0002199 ISO
    cellular_component GO:0005575 ND
    cytosol GO:0005829 ISO
    blood microparticle GO:0072562 ISO
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 IDA
 Experiment description of studies that identified Hspa1l in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Hspa1l
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hspa1l is involved
PathwayEvidenceSource
HSF1-dependent transactivation IEA Reactome





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