Gene description for Dbi
Gene name diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
Gene symbol Dbi
Other names/aliases Acbp
Acoabp3
Ep
Odn
RNACOABP3
Ttn
Species Rattus norvegicus
 Database cross references - Dbi
ExoCarta ExoCarta_25045
Vesiclepedia VP_25045
Entrez Gene 25045
UniProt P11030  
 Dbi identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Dbi
Molecular Function
    fatty-acyl-CoA binding GO:0000062 IBA
    fatty-acyl-CoA binding GO:0000062 IEA
    fatty-acyl-CoA binding GO:0000062 IPI
    protein binding GO:0005515 IPI
    benzodiazepine receptor binding GO:0030156 IDA
    long-chain fatty acyl-CoA binding GO:0036042 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    behavioral fear response GO:0001662 ISO
    hair follicle development GO:0001942 ISO
    fatty acid metabolic process GO:0006631 IBA
    acyl-CoA metabolic process GO:0006637 TAS
    triglyceride metabolic process GO:0006641 ISO
    steroid biosynthetic process GO:0006694 TAS
    learning or memory GO:0007611 ISO
    glial cell proliferation GO:0014009 IDA
    lateral ventricle development GO:0021670 ISO
    cellular response to nutrient GO:0031670 IEP
    negative regulation of fatty acid beta-oxidation GO:0031999 IDA
    regulation of synaptic transmission, GABAergic GO:0032228 IDA
    phosphatidylcholine acyl-chain remodeling GO:0036151 ISO
    skin development GO:0043588 ISO
    positive regulation of lipid biosynthetic process GO:0046889 IDA
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IMP
    long-term synaptic potentiation GO:0060291 ISO
    negative regulation of protein lipidation GO:1903060 ISO
    positive regulation of CoA-transferase activity GO:1905920 ISO
    conditioned place preference GO:1990708 IEP
    positive regulation of phospholipid transport GO:2001140 ISO
Subcellular Localization
    extracellular space GO:0005615 IDA
    endoplasmic reticulum GO:0005783 IEA
    endoplasmic reticulum GO:0005783 ISO
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    synaptic vesicle GO:0008021 IDA
    protein-lipid complex GO:0032994 ISO
    contractile muscle fiber GO:0043292 IDA
    perinuclear endoplasmic reticulum GO:0097038 ISO
 Experiment description of studies that identified Dbi in exosomes
1
Experiment ID 192
MISEV standards
CEM
Biophysical techniques
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Dbi
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dbi is involved
PathwayEvidenceSource
Fatty acid metabolism IEA Reactome
Metabolism IEA Reactome
Metabolism of lipids IEA Reactome
Mitochondrial Fatty Acid Beta-Oxidation IEA Reactome





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