Gene description for Dbi
Gene name diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
Gene symbol Dbi
Other names/aliases Acbp
Acoabp3
Ep
Odn
RNACOABP3
Ttn
Species Rattus norvegicus
 Database cross references - Dbi
ExoCarta ExoCarta_25045
Entrez Gene 25045
UniProt P11030  
 Dbi identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Dbi
Molecular Function
    protein dimerization activity GO:0046983 ISO
    fatty-acyl-CoA binding GO:0000062 IPI
    long-chain fatty acyl-CoA binding GO:0036042 ISO
    benzodiazepine receptor binding GO:0030156 IDA
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
Biological Process
    learning or memory GO:0007611 ISO
    acyl-CoA metabolic process GO:0006637 TAS
    phosphatidylcholine acyl-chain remodeling GO:0036151 ISO
    steroid biosynthetic process GO:0006694 TAS
    long-term synaptic potentiation GO:0060291 ISO
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IMP
    pancreatic juice secretion GO:0030157 IEP
    cellular response to nutrient GO:0031670 IEP
    negative regulation of fatty acid beta-oxidation GO:0031999 IDA
    protein palmitoylation GO:0018345 ISO
    skin development GO:0043588 ISO
    regulation of synaptic transmission, GABAergic GO:0032228 IDA
    positive regulation of lipid biosynthetic process GO:0046889 IDA
    lateral ventricle development GO:0021670 ISO
    hair follicle development GO:0001942 ISO
    behavioral fear response GO:0001662 ISO
    brain development GO:0007420 IEP
    glial cell proliferation GO:0014009 IDA
    triglyceride metabolic process GO:0006641 ISO
Subcellular Localization
    synaptic vesicle GO:0008021 IDA
    Golgi apparatus GO:0005794 ISO
    perinuclear endoplasmic reticulum GO:0097038 ISO
    mitochondrion GO:0005739 ISO
    nucleus GO:0005634 IDA
    contractile fiber GO:0043292 IDA
    plasma membrane GO:0005886 IDA
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IEA
 Experiment description of studies that identified Dbi in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Dbi
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dbi is involved
No pathways found





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