Gene description for Pigr
Gene name polymeric immunoglobulin receptor
Gene symbol Pigr
Other names/aliases RNPIGR2
pIgA-R
Species Rattus norvegicus
 Database cross references - Pigr
ExoCarta ExoCarta_25046
Vesiclepedia VP_25046
Entrez Gene 25046
UniProt P15083  
 Pigr identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Pigr
Molecular Function
    polymeric immunoglobulin binding GO:0001790 IEA
    polymeric immunoglobulin binding GO:0001790 ISO
    polymeric immunoglobulin receptor activity GO:0001792 IEA
    polymeric immunoglobulin receptor activity GO:0001792 ISO
    transmembrane signaling receptor activity GO:0004888 IBA
    epidermal growth factor receptor binding GO:0005154 IPI
Biological Process
    detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 IEA
    detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 ISO
    immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor GO:0002415 IBA
    immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor GO:0002415 IEA
    immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor GO:0002415 ISO
    immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor GO:0002415 ISS
    signal transduction GO:0007165 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    epidermal growth factor receptor signaling pathway GO:0007173 ISO
    Fc receptor signaling pathway GO:0038093 IEA
    Fc receptor signaling pathway GO:0038093 ISO
    receptor clustering GO:0043113 IEA
    receptor clustering GO:0043113 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    receptor complex GO:0043235 IEA
    receptor complex GO:0043235 ISO
    recycling endosome membrane GO:0055038 IDA
    secretory IgA immunoglobulin complex GO:0071751 IEA
    secretory IgA immunoglobulin complex GO:0071751 ISO
    secretory IgA immunoglobulin complex GO:0071751 ISS
 Experiment description of studies that identified Pigr in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Pigr
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pigr is involved
PathwayEvidenceSource
Immune System IEA Reactome
Innate Immune System IEA Reactome
Neutrophil degranulation IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here