Gene description for Pigr
Gene name polymeric immunoglobulin receptor
Gene symbol Pigr
Other names/aliases RNPIGR2
pIgA-R
Species Rattus norvegicus
 Database cross references - Pigr
ExoCarta ExoCarta_25046
Entrez Gene 25046
UniProt P15083  
 Pigr identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Pigr
Molecular Function
    polymeric immunoglobulin receptor activity GO:0001792 ISO
    epidermal growth factor receptor binding GO:0005154 IPI
Biological Process
    retina homeostasis GO:0001895 ISO
    detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 ISO
    epidermal growth factor receptor signaling pathway GO:0007173 ISO
    receptor clustering GO:0043113 ISO
    Fc receptor signaling pathway GO:0038093 ISO
    immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor GO:0002415 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    recycling endosome membrane GO:0055038 IDA
    integral component of membrane GO:0016021 IEA
    extracellular space GO:0005615 ISO
    transport vesicle GO:0030133 IDA
    extracellular exosome GO:0070062 ISO
    receptor complex GO:0043235 ISO
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified Pigr in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Pigr
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pigr is involved
No pathways found





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