Gene description for Cyp2d2
Gene name cytochrome P450, family 2, subfamily d, polypeptide 2
Gene symbol Cyp2d2
Other names/aliases Cyp2d26
Species Rattus norvegicus
 Database cross references - Cyp2d2
ExoCarta ExoCarta_25053
Entrez Gene 25053
UniProt P10634  
 Cyp2d2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Cyp2d2
Molecular Function
    oxygen binding GO:0019825 IBA
    steroid hydroxylase activity GO:0008395 IBA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 IBA
    aromatase activity GO:0070330 IEA
    heme binding GO:0020037 IBA
    iron ion binding GO:0005506 IEA
    arachidonic acid epoxygenase activity GO:0008392 IBA
    monooxygenase activity GO:0004497 TAS
Biological Process
    exogenous drug catabolic process GO:0042738 IBA
    female pregnancy GO:0007565 IEP
    xenobiotic metabolic process GO:0006805 IBA
    response to drug GO:0042493 IDA
    arachidonic acid metabolic process GO:0019369 IBA
    oxidation-reduction process GO:0055114 IBA
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified Cyp2d2 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Cyp2d2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cyp2d2 is involved
PathwayEvidenceSource
Xenobiotics IEA Reactome





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