Gene description for Lipa
Gene name lipase A, lysosomal acid, cholesterol esterase
Gene symbol Lipa
Other names/aliases Chole
Chole2
LAL
Lip1
Species Rattus norvegicus
 Database cross references - Lipa
ExoCarta ExoCarta_25055
Entrez Gene 25055
 Lipa identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Lipa
Molecular Function
    sterol esterase activity GO:0004771 ISO
    lipase activity GO:0016298 ISO
Biological Process
    sterol metabolic process GO:0016125 IDA
    cell proliferation GO:0008283 ISO
    lipid catabolic process GO:0016042 IEA
    fatty acid metabolic process GO:0006631 IDA
    inflammatory response GO:0006954 ISO
    tissue remodeling GO:0048771 ISO
    cytokine production GO:0001816 ISO
    lung development GO:0030324 ISO
    cell morphogenesis GO:0000902 ISO
    homeostasis of number of cells within a tissue GO:0048873 ISO
Subcellular Localization
    lysosome GO:0005764 IDA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Lipa in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Lipa
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lipa is involved
No pathways found





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