Gene description for Lipa
Gene name lipase A, lysosomal acid, cholesterol esterase
Gene symbol Lipa
Other names/aliases Chole
Chole2
LAL
Lip1
Species Rattus norvegicus
 Database cross references - Lipa
ExoCarta ExoCarta_25055
Vesiclepedia VP_25055
Entrez Gene 25055
 Lipa identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Lipa
Molecular Function
    sterol ester esterase activity GO:0004771 IBA
    sterol ester esterase activity GO:0004771 IDA
    sterol ester esterase activity GO:0004771 IEA
    sterol ester esterase activity GO:0004771 ISO
    lipase activity GO:0016298 IDA
    lipase activity GO:0016298 ISO
    hydrolase activity, acting on ester bonds GO:0016788 IEA
Biological Process
    mitotic cell cycle GO:0000278 IEA
    mitotic cell cycle GO:0000278 ISO
    cell morphogenesis GO:0000902 IEA
    cell morphogenesis GO:0000902 ISO
    retinoid metabolic process GO:0001523 ISO
    liver development GO:0001889 ISO
    endothelial cell proliferation GO:0001935 IEA
    endothelial cell proliferation GO:0001935 ISO
    response to dietary excess GO:0002021 IEA
    response to dietary excess GO:0002021 ISO
    hematopoietic progenitor cell differentiation GO:0002244 IEA
    hematopoietic progenitor cell differentiation GO:0002244 ISO
    acute inflammatory response GO:0002526 IEA
    acute inflammatory response GO:0002526 ISO
    respiratory burst involved in inflammatory response GO:0002536 IEA
    respiratory burst involved in inflammatory response GO:0002536 ISO
    glucose metabolic process GO:0006006 IEA
    glucose metabolic process GO:0006006 ISO
    glycolytic process GO:0006096 IEA
    glycolytic process GO:0006096 ISO
    lipid metabolic process GO:0006629 ISO
    fatty acid metabolic process GO:0006631 IDA
    fatty acid metabolic process GO:0006631 IEA
    fatty acid metabolic process GO:0006631 ISO
    neutral lipid metabolic process GO:0006638 ISO
    triglyceride metabolic process GO:0006641 IEA
    triglyceride metabolic process GO:0006641 ISO
    cholesterol biosynthetic process GO:0006695 IEA
    cholesterol biosynthetic process GO:0006695 ISO
    ATP biosynthetic process GO:0006754 IEA
    ATP biosynthetic process GO:0006754 ISO
    vitamin A metabolic process GO:0006776 IEA
    vitamin A metabolic process GO:0006776 ISO
    endocytosis GO:0006897 IEA
    endocytosis GO:0006897 ISO
    inflammatory response GO:0006954 ISO
    mitochondrion organization GO:0007005 IEA
    mitochondrion organization GO:0007005 ISO
    lysosome organization GO:0007040 IEA
    lysosome organization GO:0007040 ISO
    small GTPase-mediated signal transduction GO:0007264 IEA
    small GTPase-mediated signal transduction GO:0007264 ISO
    cholesterol metabolic process GO:0008203 ISO
    cell population proliferation GO:0008283 ISO
    endosome to lysosome transport GO:0008333 IEA
    endosome to lysosome transport GO:0008333 ISO
    determination of adult lifespan GO:0008340 IEA
    determination of adult lifespan GO:0008340 ISO
    response to cold GO:0009409 IEA
    response to cold GO:0009409 ISO
    response to xenobiotic stimulus GO:0009410 IEA
    response to xenobiotic stimulus GO:0009410 ISO
    gene expression GO:0010467 IEA
    gene expression GO:0010467 ISO
    cholesterol storage GO:0010878 IEA
    cholesterol storage GO:0010878 ISO
    programmed cell death GO:0012501 ISO
    lipid catabolic process GO:0016042 IEA
    sterol metabolic process GO:0016125 IBA
    sterol metabolic process GO:0016125 IDA
    sterol metabolic process GO:0016125 ISO
    lipid storage GO:0019915 ISO
    hemopoiesis GO:0030097 ISO
    myeloid cell differentiation GO:0030099 IEA
    myeloid cell differentiation GO:0030099 ISO
    T cell differentiation GO:0030217 IEA
    T cell differentiation GO:0030217 ISO
    cholesterol transport GO:0030301 ISO
    lung development GO:0030324 IEA
    lung development GO:0030324 ISO
    defecation GO:0030421 IEA
    defecation GO:0030421 ISO
    TOR signaling GO:0031929 IEA
    TOR signaling GO:0031929 ISO
    myeloid cell apoptotic process GO:0033028 IEA
    myeloid cell apoptotic process GO:0033028 ISO
    response to vitamin A GO:0033189 IEA
    response to vitamin A GO:0033189 ISO
    cholesterol efflux GO:0033344 IEA
    cholesterol efflux GO:0033344 ISO
    response to lipid GO:0033993 ISO
    common myeloid progenitor cell proliferation GO:0035726 IEA
    common myeloid progenitor cell proliferation GO:0035726 ISO
    T cell proliferation GO:0042098 IEA
    T cell proliferation GO:0042098 ISO
    lipoprotein catabolic process GO:0042159 IEA
    lipoprotein catabolic process GO:0042159 ISO
    regulation of membrane potential GO:0042391 ISO
    spleen development GO:0048536 IEA
    spleen development GO:0048536 ISO
    bone marrow development GO:0048539 IEA
    bone marrow development GO:0048539 ISO
    tissue remodeling GO:0048771 IEA
    tissue remodeling GO:0048771 ISO
    multicellular organismal-level homeostasis GO:0048871 ISO
    homeostasis of number of cells GO:0048872 ISO
    homeostasis of number of cells within a tissue GO:0048873 IEA
    homeostasis of number of cells within a tissue GO:0048873 ISO
    epithelial cell proliferation GO:0050673 ISO
    positive regulation of T cell receptor signaling pathway GO:0050862 IEA
    positive regulation of T cell receptor signaling pathway GO:0050862 ISO
    regulation of mitochondrial membrane potential GO:0051881 IEA
    regulation of mitochondrial membrane potential GO:0051881 ISO
    lipid homeostasis GO:0055088 IEA
    lipid homeostasis GO:0055088 ISO
    adipose tissue development GO:0060612 IEA
    adipose tissue development GO:0060612 ISO
    blood vessel endothelial cell differentiation GO:0060837 IEA
    blood vessel endothelial cell differentiation GO:0060837 ISO
    macrophage homeostasis GO:0061519 IEA
    macrophage homeostasis GO:0061519 ISO
    T cell apoptotic process GO:0070231 IEA
    T cell apoptotic process GO:0070231 ISO
    fat cell proliferation GO:0070341 IEA
    fat cell proliferation GO:0070341 ISO
    triglyceride-rich lipoprotein particle clearance GO:0071830 IEA
    triglyceride-rich lipoprotein particle clearance GO:0071830 ISO
    cell proliferation in bone marrow GO:0071838 IEA
    cell proliferation in bone marrow GO:0071838 ISO
    liver morphogenesis GO:0072576 IEA
    liver morphogenesis GO:0072576 ISO
    energy homeostasis GO:0097009 ISO
    lipid import into cell GO:0140354 IEA
    lipid import into cell GO:0140354 ISO
    multicellular organismal-level chemical homeostasis GO:0140962 IEA
    multicellular organismal-level chemical homeostasis GO:0140962 ISO
    response to rapamycin GO:1901355 IEA
    response to rapamycin GO:1901355 ISO
    reactive oxygen species biosynthetic process GO:1903409 IEA
    reactive oxygen species biosynthetic process GO:1903409 ISO
    adaptive thermogenesis GO:1990845 IEA
    adaptive thermogenesis GO:1990845 ISO
Subcellular Localization
    fibrillar center GO:0001650 IEA
    fibrillar center GO:0001650 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    lysosome GO:0005764 IDA
    lysosome GO:0005764 IEA
    lysosome GO:0005764 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    intracellular membrane-bounded organelle GO:0043231 IBA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Lipa in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Lipa
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lipa is involved
No pathways found





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