Gene description for Scarb1
Gene name scavenger receptor class B, member 1
Gene symbol Scarb1
Other names/aliases Cd36l1
SR-B1
Srb1
Species Rattus norvegicus
 Database cross references - Scarb1
ExoCarta ExoCarta_25073
Entrez Gene 25073
UniProt P97943  
 Scarb1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Scarb1
Molecular Function
    high-density lipoprotein particle binding GO:0008035 ISO
    protein homodimerization activity GO:0042803 IDA
    high-density lipoprotein particle receptor activity GO:0070506 ISS
    lipid transporter activity GO:0005319 TAS
    apolipoprotein binding GO:0034185 ISO
    apolipoprotein A-I binding GO:0034186 ISO
    phosphatidylserine binding GO:0001786 TAS
    lipopolysaccharide receptor activity GO:0001875 ISO
    low-density lipoprotein particle binding GO:0030169 ISS
    lipopolysaccharide binding GO:0001530 ISO
Biological Process
    vitamin transmembrane transport GO:0035461 ISO
    cell adhesion GO:0007155 IEA
    lipopolysaccharide-mediated signaling pathway GO:0031663 ISO
    cholesterol homeostasis GO:0042632 ISO
    triglyceride homeostasis GO:0070328 ISO
    androgen biosynthetic process GO:0006702 IDA
    lipopolysaccharide transport GO:0015920 ISO
    steroid biosynthetic process GO:0006694 TAS
    lipid transport GO:0006869 IMP
    cholesterol import GO:0070508 ISO
    high-density lipoprotein particle remodeling GO:0034375 ISO
    regulation of phagocytosis GO:0050764 TAS
    cholesterol transport GO:0030301 ISO
    blood vessel endothelial cell migration GO:0043534 ISO
    positive regulation of nitric-oxide synthase activity GO:0051000 ISO
    receptor-mediated endocytosis GO:0006898 ISS
    cholesterol efflux GO:0033344 ISO
    high-density lipoprotein particle clearance GO:0034384 ISS
    phospholipid transport GO:0015914 ISO
    detection of lipopolysaccharide GO:0032497 ISO
    positive regulation of cholesterol storage GO:0010886 ISS
    regulation of phosphatidylcholine catabolic process GO:0010899 ISO
    reverse cholesterol transport GO:0043691 ISS
    cholesterol catabolic process GO:0006707 ISO
    endothelial cell proliferation GO:0001935 ISO
    low-density lipoprotein particle clearance GO:0034383 ISO
    adhesion of symbiont to host GO:0044406 ISO
    positive regulation of triglyceride biosynthetic process GO:0010867 ISO
    phagocytosis, recognition GO:0006910 IMP
    recognition of apoptotic cell GO:0043654 ISS
Subcellular Localization
    plasma membrane GO:0005886 ISS
    extracellular exosome GO:0070062 ISO
    microvillus membrane GO:0031528 IDA
    lysosomal membrane GO:0005765 ISO
    cell surface GO:0009986 IDA
    integral component of membrane GO:0016021 ISO
    cytoplasm GO:0005737 IDA
    integral component of plasma membrane GO:0005887 ISO
    caveola GO:0005901 ISO
 Experiment description of studies that identified Scarb1 in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Scarb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Scarb1 is involved
PathwayEvidenceSource
HDL-mediated lipid transport IEA Reactome
Scavenging by Class B Receptors IEA Reactome





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