Gene description for Pld1
Gene name phospholipase D1, phosphatidylcholine-specific
Gene symbol Pld1
Other names/aliases Pld1a
Pld1b
Plda
Pldb
Species Rattus norvegicus
 Database cross references - Pld1
ExoCarta ExoCarta_25096
Vesiclepedia VP_25096
Entrez Gene 25096
UniProt P70496  
 Pld1 identified in sEVs derived from the following tissue/cell type
Basophilic leukemia cells 15304316    
 Gene ontology annotations for Pld1
Molecular Function
    phospholipase D activity GO:0004630 IBA
    phospholipase D activity GO:0004630 IDA
    phospholipase D activity GO:0004630 IEA
    phospholipase D activity GO:0004630 ISO
    protein binding GO:0005515 IPI
    phosphatidylinositol binding GO:0035091 IEA
Biological Process
    phosphatidic acid biosynthetic process GO:0006654 IEA
    phosphatidic acid biosynthetic process GO:0006654 IMP
    phospholipid biosynthetic process GO:0008654 IMP
    phospholipid catabolic process GO:0009395 IBA
    phospholipid catabolic process GO:0009395 IMP
    lipid catabolic process GO:0016042 IEA
    positive regulation of cell migration GO:0030335 IMP
    cellular response to nutrient GO:0031670 IEA
    cellular response to nutrient GO:0031670 ISO
    regulation of microvillus assembly GO:0032534 IBA
    regulation of microvillus assembly GO:0032534 IEA
    regulation of microvillus assembly GO:0032534 ISO
    intracellular signal transduction GO:0035556 IEA
    response to peptide hormone GO:0043434 IMP
    positive regulation of translation GO:0045727 IEA
    positive regulation of translation GO:0045727 ISO
    defense response to Gram-positive bacterium GO:0050830 ISO
    regulation of vesicle-mediated transport GO:0060627 IBA
    regulation of synaptic vesicle cycle GO:0098693 IEA
    regulation of synaptic vesicle cycle GO:0098693 ISO
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    endosome GO:0005768 IEA
    endosome GO:0005768 ISO
    endoplasmic reticulum membrane GO:0005789 IEA
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    plasma membrane GO:0005886 IBA
    endomembrane system GO:0012505 IEA
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
    lamellipodium GO:0030027 IDA
    endocytic vesicle GO:0030139 IEA
    endocytic vesicle GO:0030139 ISO
    cytoplasmic vesicle GO:0031410 IBA
    late endosome membrane GO:0031902 IEA
    vesicle GO:0031982 IDA
    Golgi cisterna GO:0031985 IDA
    synapse GO:0045202 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    cholinergic synapse GO:0098981 IEA
    cholinergic synapse GO:0098981 ISO
 Experiment description of studies that identified Pld1 in sEVs
1
Experiment ID 134
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 15304316    
Organism Rattus norvegicus
Experiment description PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes
Authors "Laulagnier K, Grand D, Dujardin A, Hamdi S, Vincent-Schneider H, Lankar D, Salles JP, Bonnerot C, Perret B, Record M."
Journal name FL
Publication year 2004
Sample Basophilic leukemia cells
Sample name RBL-2H3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
FACS
 Protein-protein interactions for Pld1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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