Gene description for Pld1
Gene name phospholipase D1, phosphatidylcholine-specific
Gene symbol Pld1
Other names/aliases Pld1a
Species Rattus norvegicus
 Database cross references - Pld1
ExoCarta ExoCarta_25096
Entrez Gene 25096
UniProt P70496  
 Pld1 identified in exosomes derived from the following tissue/cell type
Basophilic leukemia cells 15304316    
 Gene ontology annotations for Pld1
Molecular Function
    phospholipase D activity GO:0004630 IDA
    N-acylphosphatidylethanolamine-specific phospholipase D activity GO:0070290 IEA
    phosphatidylinositol binding GO:0035091 IEA
    protein binding GO:0005515 IPI
Biological Process
    inositol lipid-mediated signaling GO:0048017 IEA
    positive regulation of cell migration GO:0030335 IMP
    regulation of microvillus assembly GO:0032534 ISO
    phospholipid biosynthetic process GO:0008654 IMP
    defense response to Gram-positive bacterium GO:0050830 ISO
    regulation of phagocytosis GO:0050764 IEA
    phospholipid catabolic process GO:0009395 IMP
    response to peptide hormone GO:0043434 IMP
    phosphatidic acid biosynthetic process GO:0006654 IMP
Subcellular Localization
    lamellipodium GO:0030027 IDA
    late endosome membrane GO:0031902 IEA
    vesicle GO:0031982 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    endocytic vesicle GO:0030139 ISO
    intracellular membrane-bounded organelle GO:0043231 IDA
    Golgi cisterna GO:0031985 IDA
    apical plasma membrane GO:0016324 ISO
    Golgi apparatus GO:0005794 ISO
    endosome GO:0005768 ISO
    membrane GO:0016020 ISO
    Golgi membrane GO:0000139 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    lysosomal membrane GO:0005765 ISO
 Experiment description of studies that identified Pld1 in exosomes
Experiment ID 134
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 15304316    
Organism Rattus norvegicus
Experiment description PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes
Authors Laulagnier K, Grand D, Dujardin A, Hamdi S, Vincent-Schneider H, Lankar D, Salles JP, Bonnerot C, Perret B, Record M.
Journal name FL
Publication year 2004
Sample Basophilic leukemia cells
Sample name RBL-2H3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for Pld1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pld1 is involved
No pathways found

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