Gene description for Hsd11b1
Gene name hydroxysteroid 11-beta dehydrogenase 1
Gene symbol Hsd11b1
Other names/aliases LRRGT00065
Species Rattus norvegicus
 Database cross references - Hsd11b1
ExoCarta ExoCarta_25116
Entrez Gene 25116
UniProt P16232  
 Hsd11b1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Hsd11b1
Molecular Function
    11-beta-hydroxysteroid dehydrogenase (NADP+) activity GO:0070524 IEA
    steroid binding GO:0005496 IPI
    NADP binding GO:0050661 IDA
    oxidoreductase activity GO:0016491 IDA
    11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity GO:0003845 ISO
Biological Process
    regulation of pentose-phosphate shunt GO:0043456 IDA
    oxidation-reduction process GO:0055114 ISO
    cellular response to estradiol stimulus GO:0071392 IEP
    glucocorticoid catabolic process GO:0006713 IDA
    phthalate metabolic process GO:0018963 IEP
    glucocorticoid biosynthetic process GO:0006704 IDA
    lung development GO:0030324 ISO
    response to nutrient levels GO:0031667 IEP
    metabolic process GO:0008152 IDA
Subcellular Localization
    nuclear membrane GO:0031965 IDA
    apical part of cell GO:0045177 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    membrane GO:0016020 ISO
    cytoplasm GO:0005737 IDA
    rough endoplasmic reticulum GO:0005791 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Hsd11b1 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Hsd11b1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hsd11b1 is involved
No pathways found





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