Gene description for Umod
Gene name uromodulin
Gene symbol Umod
Other names/aliases THP
Species Rattus norvegicus
 Database cross references - Umod
ExoCarta ExoCarta_25128
Entrez Gene 25128
UniProt P27590  
 Umod identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Umod
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    IgG binding GO:0019864 ISO
Biological Process
    response to organic substance GO:0010033 IEP
    chemical homeostasis GO:0048878 ISO
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISO
    excretion GO:0007588 ISO
    leukocyte cell-cell adhesion GO:0007159 ISO
    regulation of ion homeostasis GO:2000021 ISO
    metanephric distal convoluted tubule development GO:0072221 IEA
    metanephric thick ascending limb development GO:0072233 IEA
    metanephric ascending thin limb development GO:0072218 IEA
    neutrophil migration GO:1990266 ISO
Subcellular Localization
    apical part of cell GO:0045177 IDA
    ciliary membrane GO:0060170 IEA
    cytoplasmic vesicle GO:0031410 IDA
    extracellular space GO:0005615 IDA
    spindle pole GO:0000922 ISS
    extracellular exosome GO:0070062 ISO
    apical plasma membrane GO:0016324 ISS
    membrane raft GO:0045121 IDA
    Golgi apparatus GO:0005794 IDA
    cytoplasmic membrane-bounded vesicle GO:0016023 TAS
    basolateral plasma membrane GO:0016323 ISS
    anchored component of membrane GO:0031225 ISS
    primary cilium GO:0072372 ISS
 Experiment description of studies that identified Umod in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Umod
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Umod is involved
No pathways found





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