Gene description for Umod
Gene name uromodulin
Gene symbol Umod
Other names/aliases THP
Species Rattus norvegicus
 Database cross references - Umod
ExoCarta ExoCarta_25128
Entrez Gene 25128
UniProt P27590  
 Umod identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Umod
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    IgG binding GO:0019864 ISO
Biological Process
    response to organic substance GO:0010033 IEP
    chemical homeostasis GO:0048878 ISO
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISO
    excretion GO:0007588 ISO
    leukocyte cell-cell adhesion GO:0007159 ISO
    regulation of ion homeostasis GO:2000021 ISO
    metanephric distal convoluted tubule development GO:0072221 IEA
    metanephric thick ascending limb development GO:0072233 IEA
    metanephric ascending thin limb development GO:0072218 IEA
    neutrophil migration GO:1990266 ISO
Subcellular Localization
    apical part of cell GO:0045177 IDA
    ciliary membrane GO:0060170 IEA
    cytoplasmic vesicle GO:0031410 IDA
    extracellular space GO:0005615 IDA
    spindle pole GO:0000922 ISS
    extracellular exosome GO:0070062 ISO
    apical plasma membrane GO:0016324 ISS
    membrane raft GO:0045121 IDA
    Golgi apparatus GO:0005794 IDA
    cytoplasmic membrane-bounded vesicle GO:0016023 TAS
    basolateral plasma membrane GO:0016323 ISS
    anchored component of membrane GO:0031225 ISS
    primary cilium GO:0072372 ISS
 Experiment description of studies that identified Umod in exosomes
Experiment ID 192
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Umod
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Umod is involved
No pathways found

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