Gene description for Umod
Gene name	uromodulin
Gene symbol	Umod
Other names/aliases	THP
Species	Rattus norvegicus
Database cross references - Umod
ExoCarta	ExoCarta_25128
Vesiclepedia	VP_25128
Entrez Gene	25128
UniProt	P27590
Umod identified in sEVs derived from the following tissue/cell type
Urine	20535238

Gene ontology annotations for Umod

Molecular Function     calcium ion binding GO:0005509 IEA     protein binding GO:0005515 IPI     IgG binding GO:0019864 IEA     IgG binding GO:0019864 ISO Biological Process     kidney development GO:0001822 ISO     organ or tissue specific immune response GO:0002251 ISO     renal water homeostasis GO:0003091 ISO     glomerular filtration GO:0003094 ISO     protein phosphorylation GO:0006468 ISO     lipid metabolic process GO:0006629 ISO     intracellular calcium ion homeostasis GO:0006874 ISO     intracellular sodium ion homeostasis GO:0006883 ISO     autophagy GO:0006914 ISO     apoptotic process GO:0006915 ISO     inflammatory response GO:0006954 ISO     response to unfolded protein GO:0006986 ISO     endoplasmic reticulum organization GO:0007029 ISO     heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IEA     heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISO     leukocyte cell-cell adhesion GO:0007159 IEA     leukocyte cell-cell adhesion GO:0007159 ISO     regulation of blood pressure GO:0008217 ISO     RNA splicing GO:0008380 ISO     response to xenobiotic stimulus GO:0009410 ISO     response to water deprivation GO:0009414 ISO     gene expression GO:0010467 ISO     urate transport GO:0015747 ISO     peptidyl-threonine phosphorylation GO:0018107 ISO     intracellular phosphate ion homeostasis GO:0030643 ISO     intracellular chloride ion homeostasis GO:0030644 ISO     response to lipopolysaccharide GO:0032496 ISO     tumor necrosis factor-mediated signaling pathway GO:0033209 ISO     cellular response to stress GO:0033554 ISO     multicellular organismal response to stress GO:0033555 ISO     cellular response to unfolded protein GO:0034620 ISO     response to endoplasmic reticulum stress GO:0034976 ISO     regulation of urine volume GO:0035809 ISO     ERAD pathway GO:0036503 ISO     protein transport into plasma membrane raft GO:0044861 ISO     innate immune response GO:0045087 IEA     citric acid secretion GO:0046720 ISO     multicellular organismal-level homeostasis GO:0048871 ISO     chemical homeostasis GO:0048878 ISO     monoatomic ion homeostasis GO:0050801 ISO     defense response to Gram-negative bacterium GO:0050829 IEA     defense response to Gram-negative bacterium GO:0050829 ISO     defense response to Gram-negative bacterium GO:0050829 ISO     defense response to Gram-negative bacterium GO:0050829 ISS     multicellular organismal-level water homeostasis GO:0050891 ISO     regulation of protein transport GO:0051223 ISO     phosphate ion homeostasis GO:0055062 ISO     chloride ion homeostasis GO:0055064 ISO     calcium ion homeostasis GO:0055074 ISO     potassium ion homeostasis GO:0055075 ISO     sodium ion homeostasis GO:0055078 ISO     micturition GO:0060073 ISO     chaperone-mediated protein folding GO:0061077 ISO     renal sodium ion absorption GO:0070294 ISO     urea transmembrane transport GO:0071918 ISO     collecting duct development GO:0072044 ISO     juxtaglomerular apparatus development GO:0072051 ISO     loop of Henle development GO:0072070 ISO     metanephric ascending thin limb development GO:0072218 ISO     metanephric distal convoluted tubule development GO:0072221 ISO     metanephric thick ascending limb development GO:0072233 ISO     protein localization to vacuole GO:0072665 ISO     apoptotic signaling pathway GO:0097190 ISO     connective tissue replacement GO:0097709 ISO     renal urate salt excretion GO:0097744 ISO     antibacterial innate immune response GO:0140367 IEA     antibacterial innate immune response GO:0140367 ISO     antibacterial innate immune response GO:0140367 ISS     neutrophil migration GO:1990266 IBA     neutrophil migration GO:1990266 IEA     neutrophil migration GO:1990266 ISO Subcellular Localization     spindle pole GO:0000922 IEA     spindle pole GO:0000922 ISO     spindle pole GO:0000922 ISS     extracellular region GO:0005576 IEA     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     endoplasmic reticulum GO:0005783 ISO     plasma membrane GO:0005886 ISO     cilium GO:0005929 ISO     cilium GO:0005929 ISS     cell surface GO:0009986 IBA     membrane GO:0016020 ISO     membrane GO:0016020 ISS     basolateral plasma membrane GO:0016323 IEA     basolateral plasma membrane GO:0016323 ISO     basolateral plasma membrane GO:0016323 ISS     apical plasma membrane GO:0016324 IBA     apical plasma membrane GO:0016324 IEA     apical plasma membrane GO:0016324 ISO     apical plasma membrane GO:0016324 ISS     apical part of cell GO:0045177 IDA     ciliary membrane GO:0060170 IEA     side of membrane GO:0098552 IEA