Gene description for Cd24
Gene name CD24 molecule
Gene symbol Cd24
Other names/aliases Cd24a
Species Rattus norvegicus
 Database cross references - Cd24
ExoCarta ExoCarta_25145
Vesiclepedia VP_25145
Entrez Gene 25145
UniProt Q07490  
 Cd24 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Cd24
Molecular Function
    protein kinase binding GO:0019901 ISO
    protein kinase binding GO:0019901 ISS
    carbohydrate binding GO:0030246 ISO
    protein tyrosine kinase activator activity GO:0030296 IBA
    protein tyrosine kinase activator activity GO:0030296 ISO
    protein tyrosine kinase activator activity GO:0030296 ISS
    Hsp70 protein binding GO:0030544 ISO
    Hsp90 protein binding GO:0051879 ISO
Biological Process
    response to hypoxia GO:0001666 ISO
    response to hypoxia GO:0001666 ISS
    cell activation GO:0001775 IBA
    cell activation GO:0001775 ISO
    cell activation GO:0001775 ISS
    T cell homeostatic proliferation GO:0001777 ISO
    B cell apoptotic process GO:0001783 ISO
    regulation of cytokine-mediated signaling pathway GO:0001959 ISO
    regulation of cytokine-mediated signaling pathway GO:0001959 ISS
    response to molecule of bacterial origin GO:0002237 ISO
    response to molecule of bacterial origin GO:0002237 ISS
    pre-B cell differentiation GO:0002329 ISO
    leukocyte migration involved in inflammatory response GO:0002523 ISO
    positive regulation of T cell mediated immune response to tumor cell GO:0002842 ISO
    positive regulation of inflammatory response to antigenic stimulus GO:0002863 ISO
    positive regulation of B cell apoptotic process GO:0002904 ISO
    immune response GO:0006955 IEP
    cell adhesion GO:0007155 IEA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISO
    leukocyte cell-cell adhesion GO:0007159 ISO
    cell surface receptor signaling pathway GO:0007166 ISO
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISO
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISS
    neuromuscular synaptic transmission GO:0007274 ISO
    neuroblast proliferation GO:0007405 ISO
    negative regulation of neuroblast proliferation GO:0007406 ISO
    apoptotic mitochondrial changes GO:0008637 ISO
    positive regulation of neuron projection development GO:0010976 ISO
    cell migration GO:0016477 ISO
    cell migration GO:0016477 ISS
    peptidyl-tyrosine phosphorylation GO:0018108 ISO
    calcium-mediated signaling GO:0019722 ISO
    regulation of cell-cell adhesion GO:0022407 IBA
    regulation of cell-cell adhesion GO:0022407 ISO
    positive regulation of cell-cell adhesion GO:0022409 ISO
    apoptotic nuclear changes GO:0030262 ISO
    negative regulation of B cell proliferation GO:0030889 ISO
    neuron projection development GO:0031175 ISO
    neuron projection development GO:0031175 ISO
    T cell costimulation GO:0031295 ISO
    T cell costimulation GO:0031295 ISS
    B cell receptor transport into membrane raft GO:0032597 ISO
    B cell receptor transport into membrane raft GO:0032597 ISS
    chemokine receptor transport out of membrane raft GO:0032600 ISO
    chemokine receptor transport out of membrane raft GO:0032600 ISS
    negative regulation of interleukin-6 production GO:0032715 ISO
    negative regulation of tumor necrosis factor production GO:0032720 ISO
    negative regulation of transforming growth factor beta3 production GO:0032913 ISO
    negative regulation of transforming growth factor beta3 production GO:0032913 ISS
    integrin activation GO:0033622 ISO
    positive regulation of integrin activation GO:0033625 ISO
    positive regulation of cell adhesion mediated by integrin GO:0033630 ISO
    regulation of cell-cell adhesion mediated by integrin GO:0033632 ISO
    positive regulation of cell-cell adhesion mediated by integrin GO:0033634 ISO
    negative regulation of erythrocyte clearance GO:0034107 ISO
    homotypic cell-cell adhesion GO:0034109 ISO
    negative regulation of erythrocyte aggregation GO:0034119 ISO
    CD4-positive, alpha-beta T cell proliferation GO:0035739 ISO
    B cell proliferation GO:0042100 ISO
    positive regulation of T cell homeostatic proliferation GO:0042103 ISO
    positive regulation of activated T cell proliferation GO:0042104 ISO
    positive regulation of activated T cell proliferation GO:0042104 ISS
    regulation of phosphorylation GO:0042325 ISO
    regulation of phosphorylation GO:0042325 ISS
    cholesterol homeostasis GO:0042632 ISO
    cholesterol homeostasis GO:0042632 ISS
    positive regulation of MAP kinase activity GO:0043406 ISO
    positive regulation of MAP kinase activity GO:0043406 ISS
    regulation of MAPK cascade GO:0043408 ISO
    regulation of MAPK cascade GO:0043408 ISS
    response to estrogen GO:0043627 ISO
    response to estrogen GO:0043627 ISS
    regulation of B cell differentiation GO:0045577 ISO
    negative regulation of neuron differentiation GO:0045665 ISO
    respiratory burst GO:0045730 ISO
    respiratory burst GO:0045730 ISS
    negative regulation of T cell homeostatic proliferation GO:0046014 ISO
    positive regulation of alpha-beta T cell proliferation GO:0046641 ISO
    synaptic vesicle endocytosis GO:0048488 ISO
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    negative regulation of neurogenesis GO:0050768 ISO
    positive regulation of calcium-mediated signaling GO:0050850 ISO
    negative regulation of monocyte chemotactic protein-1 production GO:0071638 ISO
    podocyte differentiation GO:0072112 ISO
    podocyte differentiation GO:0072112 ISS
    glomerular parietal epithelial cell differentiation GO:0072139 ISO
    glomerular parietal epithelial cell differentiation GO:0072139 ISS
    apoptotic signaling pathway GO:0097190 ISO
    negative regulation of inflammatory response to wounding GO:0106015 ISO
    positive regulation of inflammatory response to wounding GO:0106016 ISO
    positive regulation of CD4-positive, alpha-beta T cell proliferation GO:2000563 ISO
    positive regulation of nephron tubule epithelial cell differentiation GO:2000768 ISO
    positive regulation of nephron tubule epithelial cell differentiation GO:2000768 ISS
Subcellular Localization
    plasma membrane GO:0005886 ISO
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IDA
    external side of plasma membrane GO:0009897 ISO
    cell surface GO:0009986 ISO
    cell surface GO:0009986 ISS
    membrane GO:0016020 IEA
    membrane GO:0016020 ISO
    membrane GO:0016020 ISS
    motile cilium GO:0031514 ISO
    microvillus membrane GO:0031528 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    membrane raft GO:0045121 IBA
    membrane raft GO:0045121 ISO
    membrane raft GO:0045121 ISS
    ciliary membrane GO:0060170 ISO
    presynapse GO:0098793 IEA
 Experiment description of studies that identified Cd24 in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Cd24
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd24 is involved
No pathways found





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