Gene description for Igf2r
Gene name insulin-like growth factor 2 receptor
Gene symbol Igf2r
Other names/aliases Igfr2
Species Rattus norvegicus
 Database cross references - Igf2r
ExoCarta ExoCarta_25151
Vesiclepedia VP_25151
Entrez Gene 25151
 Igf2r identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Igf2r
Molecular Function
    G-protein alpha-subunit binding GO:0001965 IDA
    retinoic acid binding GO:0001972 IDA
    insulin-like growth factor receptor activity GO:0005010 TAS
    insulin-like growth factor binding GO:0005520 IBA
    insulin-like growth factor binding GO:0005520 ISO
    D-mannose binding GO:0005537 ISO
    enzyme binding GO:0019899 IDA
    insulin-like growth factor II binding GO:0031995 IDA
    identical protein binding GO:0042802 ISO
    phosphoprotein binding GO:0051219 ISO
    retromer complex binding GO:1905394 ISO
Biological Process
    liver development GO:0001889 IDA
    lysosomal transport GO:0007041 IBA
    G protein-coupled receptor signaling pathway GO:0007186 IMP
    spermatogenesis GO:0007283 IEP
    post-embryonic development GO:0009791 IEP
    animal organ regeneration GO:0031100 IEP
    response to retinoic acid GO:0032526 IDA
    regulation of apoptotic process GO:0042981 IMP
    positive regulation of apoptotic process GO:0043065 IMP
    positive regulation by host of viral process GO:0044794 IEA
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    response to tetrachloromethane GO:1904772 IEP
Subcellular Localization
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 ISO
    nuclear envelope lumen GO:0005641 ISO
    endosome GO:0005768 IDA
    endosome GO:0005768 ISO
    early endosome GO:0005769 ISO
    late endosome GO:0005770 IBA
    late endosome GO:0005770 IDA
    late endosome GO:0005770 ISO
    Golgi apparatus GO:0005794 ISO
    trans-Golgi network GO:0005802 IBA
    trans-Golgi network GO:0005802 IDA
    trans-Golgi network GO:0005802 ISO
    plasma membrane GO:0005886 IBA
    cell surface GO:0009986 ISO
    endosome membrane GO:0010008 ISO
    membrane GO:0016020 ISO
    clathrin coat GO:0030118 IDA
    endocytic vesicle GO:0030139 ISO
    trans-Golgi network transport vesicle GO:0030140 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified Igf2r in sEVs
1
Experiment ID 90
MISEV standards
✔
EM
Biophysical techniques
✔
HSC70|HSP90|TSG101|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Igf2r
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Igf2r is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here