Gene description for Igf2r
Gene name insulin-like growth factor 2 receptor
Gene symbol Igf2r
Other names/aliases Igfr2
Species Rattus norvegicus
 Database cross references - Igf2r
ExoCarta ExoCarta_25151
Entrez Gene 25151
 Igf2r identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Igf2r
Molecular Function
    insulin-like growth factor-activated receptor activity GO:0005010 TAS
    G-protein coupled receptor activity GO:0004930 IMP
    identical protein binding GO:0042802 ISO
    retinoic acid binding GO:0001972 IDA
    enzyme binding GO:0019899 IDA
    mannose binding GO:0005537 ISO
    phosphoprotein binding GO:0051219 ISO
    transporter activity GO:0005215 IEA
    insulin-like growth factor II binding GO:0031995 IDA
    insulin-like growth factor binding GO:0005520 ISO
    glycoprotein binding GO:0001948 ISO
    G-protein alpha-subunit binding GO:0001965 IDA
Biological Process
    organ regeneration GO:0031100 IEP
    G-protein coupled receptor signaling pathway GO:0007186 IMP
    protein transport GO:0015031 TAS
    transport GO:0006810 IEA
    regulation of apoptotic process GO:0042981 IMP
    response to retinoic acid GO:0032526 IDA
    positive regulation of apoptotic process GO:0043065 IMP
    post-embryonic development GO:0009791 IEP
    liver development GO:0001889 IDA
    spermatogenesis GO:0007283 IEP
Subcellular Localization
    early endosome GO:0005769 ISO
    clathrin coat GO:0030118 IDA
    endosome GO:0005768 ISO
    integral component of membrane GO:0016021 TAS
    extracellular space GO:0005615 IDA
    late endosome GO:0005770 ISO
    nucleus GO:0005634 ISO
    focal adhesion GO:0005925 ISO
    membrane GO:0016020 ISO
    extracellular exosome GO:0070062 ISO
    trans-Golgi network transport vesicle GO:0030140 ISO
    nuclear envelope lumen GO:0005641 ISO
    cell surface GO:0009986 ISO
    trans-Golgi network GO:0005802 ISO
    plasma membrane GO:0005886 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    endocytic vesicle GO:0030139 ISO
 Experiment description of studies that identified Igf2r in exosomes
1
Experiment ID 90
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSC70|HSP90|TSG101
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Igf2r
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Igf2r is involved
No pathways found





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