Gene description for Dpp4
Gene name dipeptidylpeptidase 4
Gene symbol Dpp4
Other names/aliases CD26
DPPIV
Species Rattus norvegicus
 Database cross references - Dpp4
ExoCarta ExoCarta_25253
Entrez Gene 25253
UniProt P14740  
 Dpp4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
Urine 20535238    
 Gene ontology annotations for Dpp4
Molecular Function
    serine-type endopeptidase activity GO:0004252 IEA
    identical protein binding GO:0042802 ISO
    serine-type peptidase activity GO:0008236 ISO
    peptide binding GO:0042277 IDA
    dipeptidyl-peptidase activity GO:0008239 ISS
    protease binding GO:0002020 ISS
    protein homodimerization activity GO:0042803 ISS
    receptor binding GO:0005102 ISS
    virus receptor activity GO:0001618 ISO
    collagen binding GO:0005518 IDA
Biological Process
    viral entry into host cell GO:0046718 ISO
    cell adhesion GO:0007155 IEA
    regulation of cell-cell adhesion mediated by integrin GO:0033632 ISO
    regulation of T cell mediated immunity GO:0002709 IMP
    proteolysis GO:0006508 TAS
    T cell activation GO:0042110 ISO
    endothelial cell migration GO:0043542 ISS
    establishment of localization GO:0051234 IMP
    locomotory exploration behavior GO:0035641 ISO
    psychomotor behavior GO:0036343 ISO
    response to hypoxia GO:0001666 ISO
    positive regulation of cell proliferation GO:0008284 ISS
    behavioral fear response GO:0001662 ISO
    negative regulation of extracellular matrix disassembly GO:0010716 ISS
    T cell costimulation GO:0031295 ISS
Subcellular Localization
    intercellular canaliculus GO:0046581 ISO
    membrane raft GO:0045121 IEA
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 ISO
    lamellipodium GO:0030027 ISS
    lamellipodium membrane GO:0031258 IEA
    lysosomal membrane GO:0005765 ISO
    cell junction GO:0030054 IEA
    cell surface GO:0009986 ISS
    extracellular region GO:0005576 IEA
    endocytic vesicle GO:0030139 ISS
    extracellular exosome GO:0070062 ISO
    focal adhesion GO:0005925 ISO
    Golgi apparatus GO:0005794 IDA
    endoplasmic reticulum GO:0005783 IDA
    invadopodium membrane GO:0071438 ISS
    apical plasma membrane GO:0016324 ISO
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Dpp4 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
2
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Dpp4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dpp4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here