Gene description for Gclc
Gene name	glutamate-cysteine ligase, catalytic subunit
Gene symbol	Gclc
Other names/aliases	Glclc
Species	Rattus norvegicus
Database cross references - Gclc
ExoCarta	ExoCarta_25283
Vesiclepedia	VP_25283
Entrez Gene	25283
UniProt	P19468
Gclc identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479
Reticulocytes	21828046
Reticulocytes	21828046
Urine	20535238

Gene ontology annotations for Gclc

Molecular Function     magnesium ion binding GO:0000287 ISO     magnesium ion binding GO:0000287 ISS     glutamate-cysteine ligase activity GO:0004357 IBA     glutamate-cysteine ligase activity GO:0004357 IDA     glutamate-cysteine ligase activity GO:0004357 IEA     glutamate-cysteine ligase activity GO:0004357 IMP     glutamate-cysteine ligase activity GO:0004357 ISO     glutamate-cysteine ligase activity GO:0004357 ISS     ATP binding GO:0005524 IEA     glutamate binding GO:0016595 ISO     glutamate binding GO:0016595 ISS     ADP binding GO:0043531 ISO     ADP binding GO:0043531 ISS     protein-containing complex binding GO:0044877 IDA Biological Process     cysteine metabolic process GO:0006534 ISO     cysteine metabolic process GO:0006534 ISS     glutamate metabolic process GO:0006536 ISO     glutamate metabolic process GO:0006536 ISS     glutathione metabolic process GO:0006749 ISO     glutathione biosynthetic process GO:0006750 IBA     glutathione biosynthetic process GO:0006750 IEA     glutathione biosynthetic process GO:0006750 IMP     glutathione biosynthetic process GO:0006750 ISO     glutathione biosynthetic process GO:0006750 ISO     glutathione biosynthetic process GO:0006750 ISS     response to oxidative stress GO:0006979 IMP     response to oxidative stress GO:0006979 ISO     response to oxidative stress GO:0006979 ISS     response to nutrient GO:0007584 IEP     response to heat GO:0009408 ISO     response to heat GO:0009408 ISS     response to xenobiotic stimulus GO:0009410 ISO     response to hormone GO:0009725 ISO     response to hormone GO:0009725 ISS     response to auditory stimulus GO:0010996 ISO     response to activity GO:0014823 IEP     L-ascorbic acid metabolic process GO:0019852 ISO     negative regulation of protein ubiquitination GO:0031397 ISO     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISO     cellular response to insulin stimulus GO:0032869 IEP     cellular response to hepatocyte growth factor stimulus GO:0035729 IEP     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISS     negative regulation of neuron apoptotic process GO:0043524 IMP     cellular response to fibroblast growth factor stimulus GO:0044344 IEP     response to human chorionic gonadotropin GO:0044752 IEP     cell redox homeostasis GO:0045454 ISO     cell redox homeostasis GO:0045454 ISS     negative regulation of DNA-templated transcription GO:0045892 ISO     negative regulation of DNA-templated transcription GO:0045892 ISS     response to arsenic-containing substance GO:0046685 ISO     response to cadmium ion GO:0046686 IEP     response to nitrosative stress GO:0051409 IMP     regulation of mitochondrial depolarization GO:0051900 ISO     response to interleukin-1 GO:0070555 IEP     cellular response to mechanical stimulus GO:0071260 IEP     cellular response to glucose stimulus GO:0071333 IEP     cellular response to follicle-stimulating hormone stimulus GO:0071372 IEP     cellular response to thyroxine stimulus GO:0097069 IEP     blood vessel diameter maintenance GO:0097746 ISO     blood vessel diameter maintenance GO:0097746 ISS     negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901029 ISO     negative regulation of hepatic stellate cell activation GO:2000490 IMP     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO Subcellular Localization     mitochondrion GO:0005739 IEA     cytosol GO:0005829 ISO     glutamate-cysteine ligase complex GO:0017109 IBA     glutamate-cysteine ligase complex GO:0017109 IDA     glutamate-cysteine ligase complex GO:0017109 ISO