Gene description for Adcy6
Gene name adenylate cyclase 6
Gene symbol Adcy6
Other names/aliases ACVI
ADCYB
Species Rattus norvegicus
 Database cross references - Adcy6
ExoCarta ExoCarta_25289
Vesiclepedia VP_25289
Entrez Gene 25289
UniProt Q03343  
 Adcy6 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Adcy6
Molecular Function
    SNARE binding GO:0000149 IDA
    adenylate cyclase activity GO:0004016 IBA
    adenylate cyclase activity GO:0004016 IDA
    adenylate cyclase activity GO:0004016 IEA
    adenylate cyclase activity GO:0004016 ISO
    protein kinase C binding GO:0005080 IEA
    protein kinase C binding GO:0005080 ISO
    signaling receptor binding GO:0005102 IPI
    ATP binding GO:0005524 IEA
    calcium- and calmodulin-responsive adenylate cyclase activity GO:0008294 IDA
    calcium- and calmodulin-responsive adenylate cyclase activity GO:0008294 ISO
    protein kinase binding GO:0019901 IPI
    metal ion binding GO:0046872 IEA
    scaffold protein binding GO:0097110 ISO
Biological Process
    renal water homeostasis GO:0003091 ISO
    renal water homeostasis GO:0003091 ISS
    cAMP biosynthetic process GO:0006171 IDA
    cAMP biosynthetic process GO:0006171 IEA
    cAMP biosynthetic process GO:0006171 IMP
    cAMP biosynthetic process GO:0006171 ISO
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 ISO
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 ISS
    adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 IEA
    adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 ISO
    adenylate cyclase-activating serotonin receptor signaling pathway GO:0007192 IEA
    adenylate cyclase-activating serotonin receptor signaling pathway GO:0007192 ISO
    circadian rhythm GO:0007623 IEP
    negative regulation of neuron projection development GO:0010977 IMP
    negative regulation of neuron projection development GO:0010977 ISO
    intracellular signal transduction GO:0035556 IEA
    negative regulation of urine volume GO:0035811 ISO
    negative regulation of urine volume GO:0035811 ISS
    cellular response to prostaglandin E stimulus GO:0071380 IEA
    cellular response to prostaglandin E stimulus GO:0071380 ISO
    cellular response to catecholamine stimulus GO:0071870 ISO
    maintenance of protein location in plasma membrane GO:0072660 IMP
    blood vessel diameter maintenance GO:0097746 IEA
    blood vessel diameter maintenance GO:0097746 ISO
    cellular response to vasopressin GO:1904117 ISO
    cellular response to vasopressin GO:1904117 ISS
    cellular response to forskolin GO:1904322 IEA
    cellular response to forskolin GO:1904322 ISO
    cellular response to forskolin GO:1904322 ISS
Subcellular Localization
    endosome GO:0005768 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    cilium GO:0005929 IEA
    membrane GO:0016020 IDA
    microvillus membrane GO:0031528 IDA
    stereocilium GO:0032420 IEA
    sarcolemma GO:0042383 IDA
 Experiment description of studies that identified Adcy6 in sEVs
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Adcy6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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