Gene description for Alox5
Gene name	arachidonate 5-lipoxygenase
Gene symbol	Alox5
Other names/aliases	LOX5A
Species	Rattus norvegicus
Database cross references - Alox5
ExoCarta	ExoCarta_25290
Vesiclepedia	VP_25290
Entrez Gene	25290
UniProt	P12527
Alox5 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Alox5

Molecular Function     arachidonate 5-lipoxygenase activity GO:0004051 IBA     arachidonate 5-lipoxygenase activity GO:0004051 IEA     arachidonate 5-lipoxygenase activity GO:0004051 ISO     arachidonate 5-lipoxygenase activity GO:0004051 ISS     arachidonate 12(S)-lipoxygenase activity GO:0004052 IEA     iron ion binding GO:0005506 IEA     iron ion binding GO:0005506 ISO     iron ion binding GO:0005506 ISS     protein binding GO:0005515 IPI     oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 IEA     hydrolase activity GO:0016787 IEA     arachidonate 8(S)-lipoxygenase activity GO:0036403 IEA Biological Process     negative regulation of endothelial cell proliferation GO:0001937 IEA     negative regulation of endothelial cell proliferation GO:0001937 ISO     negative regulation of endothelial cell proliferation GO:0001937 ISS     leukocyte chemotaxis involved in inflammatory response GO:0002232 IEA     leukocyte chemotaxis involved in inflammatory response GO:0002232 ISO     leukocyte chemotaxis involved in inflammatory response GO:0002232 ISS     leukocyte migration involved in inflammatory response GO:0002523 ISO     leukocyte migration involved in inflammatory response GO:0002523 ISS     leukotriene production involved in inflammatory response GO:0002540 IEA     leukotriene production involved in inflammatory response GO:0002540 ISO     leukotriene metabolic process GO:0006691 ISO     inflammatory response GO:0006954 ISO     humoral immune response GO:0006959 IEA     humoral immune response GO:0006959 ISO     humoral immune response GO:0006959 ISS     response to nutrient GO:0007584 IEP     negative regulation of angiogenesis GO:0016525 ISO     negative regulation of angiogenesis GO:0016525 ISS     arachidonate metabolic process GO:0019369 IBA     leukotriene biosynthetic process GO:0019370 ISO     leukotriene biosynthetic process GO:0019370 ISO     leukotriene biosynthetic process GO:0019370 ISS     leukotriene biosynthetic process GO:0019370 TAS     lipoxygenase pathway GO:0019372 IBA     positive regulation of bone mineralization GO:0030501 IEA     positive regulation of bone mineralization GO:0030501 ISO     positive regulation of bone mineralization GO:0030501 ISS     lipid oxidation GO:0034440 IBA     lipid oxidation GO:0034440 IEA     dendritic cell migration GO:0036336 IEA     dendritic cell migration GO:0036336 ISO     dendritic cell migration GO:0036336 ISS     glucose homeostasis GO:0042593 IEA     glucose homeostasis GO:0042593 ISO     glucose homeostasis GO:0042593 ISS     regulation of fat cell differentiation GO:0045598 IEA     regulation of fat cell differentiation GO:0045598 ISO     regulation of fat cell differentiation GO:0045598 ISS     positive regulation of vasoconstriction GO:0045907 IMP     regulation of inflammatory response GO:0050727 ISO     regulation of inflammatory response GO:0050727 ISS     negative regulation of inflammatory response GO:0050728 IEA     negative regulation of inflammatory response GO:0050728 ISO     negative regulation of inflammatory response GO:0050728 ISS     regulation of insulin secretion GO:0050796 IEA     regulation of insulin secretion GO:0050796 ISO     regulation of insulin secretion GO:0050796 ISS     response to hyperoxia GO:0055093 IEP     negative regulation of vascular wound healing GO:0061044 IEA     negative regulation of vascular wound healing GO:0061044 ISO     negative regulation of vascular wound healing GO:0061044 ISS     negative regulation of wound healing GO:0061045 ISO     negative regulation of wound healing GO:0061045 ISS     regulation of inflammatory response to wounding GO:0106014 IEA     regulation of inflammatory response to wounding GO:0106014 ISO     regulation of inflammatory response to wounding GO:0106014 ISS     regulation of cytokine production involved in inflammatory response GO:1900015 IEA     regulation of cytokine production involved in inflammatory response GO:1900015 ISO     regulation of cytokine production involved in inflammatory response GO:1900015 ISS     regulation of cellular response to oxidative stress GO:1900407 IEA     regulation of cellular response to oxidative stress GO:1900407 ISO     regulation of cellular response to oxidative stress GO:1900407 ISS     leukotriene A4 biosynthetic process GO:1901753 IEA     leukotriene A4 biosynthetic process GO:1901753 ISO     leukotriene A4 biosynthetic process GO:1901753 ISS     regulation of reactive oxygen species biosynthetic process GO:1903426 IEA     regulation of reactive oxygen species biosynthetic process GO:1903426 ISO     regulation of reactive oxygen species biosynthetic process GO:1903426 ISS     negative regulation of response to endoplasmic reticulum stress GO:1903573 IEA     negative regulation of response to endoplasmic reticulum stress GO:1903573 ISO     negative regulation of response to endoplasmic reticulum stress GO:1903573 ISS     negative regulation of sprouting angiogenesis GO:1903671 IEA     negative regulation of sprouting angiogenesis GO:1903671 ISO     negative regulation of sprouting angiogenesis GO:1903671 ISS     positive regulation of cytochrome-c oxidase activity GO:1904960 IMP     positive regulation of leukocyte adhesion to arterial endothelial cell GO:1904999 IEA     positive regulation of leukocyte adhesion to arterial endothelial cell GO:1904999 ISO     positive regulation of leukocyte adhesion to arterial endothelial cell GO:1904999 ISS     lipoxin biosynthetic process GO:2001301 IEA     lipoxin biosynthetic process GO:2001301 ISO     lipoxin biosynthetic process GO:2001301 ISS Subcellular Localization     nucleus GO:0005634 ISO     nuclear envelope GO:0005635 IBA     nuclear envelope GO:0005635 IDA     nuclear envelope GO:0005635 ISO     nuclear envelope GO:0005635 TAS     nuclear envelope lumen GO:0005641 IEA     nuclear envelope lumen GO:0005641 ISO     nuclear envelope lumen GO:0005641 ISS     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISS     nuclear matrix GO:0016363 IEA     nuclear matrix GO:0016363 ISO     dendrite GO:0030425 IDA     nuclear membrane GO:0031965 IEA     nuclear membrane GO:0031965 ISO     nuclear membrane GO:0031965 ISS     sarcolemma GO:0042383 IDA     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     perinuclear region of cytoplasm GO:0048471 ISS