Gene description for Dync1li1
Gene name dynein cytoplasmic 1 light intermediate chain 1
Gene symbol Dync1li1
Other names/aliases Dncli1
Dnclic1
Species Rattus norvegicus
 Database cross references - Dync1li1
ExoCarta ExoCarta_252902
Vesiclepedia VP_252902
Entrez Gene 252902
UniProt Q9QXU8  
 Dync1li1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Dync1li1
Molecular Function
    ATP binding GO:0005524 IEA
    GTP binding GO:0005525 ISO
    GDP binding GO:0019003 IEA
    GDP binding GO:0019003 ISO
    protein-macromolecule adaptor activity GO:0030674 IEA
    protein-macromolecule adaptor activity GO:0030674 ISO
    identical protein binding GO:0042802 IPI
    dynein heavy chain binding GO:0045504 IBA
    dynein heavy chain binding GO:0045504 IEA
    dynein heavy chain binding GO:0045504 ISO
    molecular adaptor activity GO:0060090 ISO
Biological Process
    microtubule cytoskeleton organization GO:0000226 IBA
    microtubule-based movement GO:0007018 IBA
    microtubule-based movement GO:0007018 IEA
    microtubule-based movement GO:0007018 ISO
    microtubule-based movement GO:0007018 ISS
    regulation of centrosome cycle GO:0046605 IDA
    cell division GO:0051301 IEA
    regulation of vesicle-mediated transport GO:0060627 IEA
    regulation of vesicle-mediated transport GO:0060627 ISO
    regulation of vesicle-mediated transport GO:0060627 ISS
    early endosome to recycling endosome transport GO:0061502 IEA
    early endosome to recycling endosome transport GO:0061502 ISO
    positive regulation of mitotic cell cycle spindle assembly checkpoint GO:0090267 IEA
    positive regulation of mitotic cell cycle spindle assembly checkpoint GO:0090267 ISO
    positive regulation of mitotic cell cycle spindle assembly checkpoint GO:0090267 ISS
    cellular response to nerve growth factor stimulus GO:1990090 IDA
Subcellular Localization
    kinetochore GO:0000776 IDA
    kinetochore GO:0000776 IEA
    kinetochore GO:0000776 ISO
    kinetochore GO:0000776 ISS
    spindle pole GO:0000922 IEA
    spindle pole GO:0000922 ISO
    spindle pole GO:0000922 ISS
    cytoplasm GO:0005737 IEA
    late endosome GO:0005770 IDA
    centrosome GO:0005813 IDA
    centrosome GO:0005813 IEA
    centrosome GO:0005813 ISO
    cytoplasmic dynein complex GO:0005868 IBA
    cytoplasmic dynein complex GO:0005868 IEA
    cytoplasmic dynein complex GO:0005868 ISO
    cytoplasmic dynein complex GO:0005868 ISS
    microtubule GO:0005874 IEA
    endocytic vesicle membrane GO:0030666 IEA
    endocytic vesicle membrane GO:0030666 ISO
    endocytic vesicle membrane GO:0030666 ISS
    recycling endosome membrane GO:0055038 IEA
 Experiment description of studies that identified Dync1li1 in sEVs
1
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Dync1li1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Snca  
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Dync1li1 is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Aggrephagy IEA Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal IEA Reactome
Amplification of signal from the kinetochores IEA Reactome
Asparagine N-linked glycosylation IEA Reactome
Autophagy IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
COPI-independent Golgi-to-ER retrograde traffic IEA Reactome
COPI-mediated anterograde transport IEA Reactome
EML4 and NUDC in mitotic spindle formation IEA Reactome
ER to Golgi Anterograde Transport IEA Reactome
Golgi-to-ER retrograde transport IEA Reactome
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic IEA Reactome
M Phase IEA Reactome
Macroautophagy IEA Reactome
Membrane Trafficking IEA Reactome
Metabolism of proteins IEA Reactome
MHC class II antigen presentation IEA Reactome
Mitotic Anaphase IEA Reactome
Mitotic Metaphase and Anaphase IEA Reactome
Mitotic Prometaphase IEA Reactome
Mitotic Spindle Checkpoint IEA Reactome
Neutrophil degranulation IEA Reactome
Post-translational protein modification IEA Reactome
Resolution of Sister Chromatid Cohesion IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases Activate Formins IEA Reactome
Selective autophagy IEA Reactome
Separation of Sister Chromatids IEA Reactome
Signal Transduction IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Transport to the Golgi and subsequent modification IEA Reactome
Vesicle-mediated transport IEA Reactome





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