Gene description for Comp
Gene name cartilage oligomeric matrix protein
Gene symbol Comp
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Comp
ExoCarta ExoCarta_25304
Vesiclepedia VP_25304
Entrez Gene 25304
UniProt P35444  
 Comp identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Comp
Molecular Function
    fibronectin binding GO:0001968 IDA
    protease binding GO:0002020 IEA
    protease binding GO:0002020 ISO
    integrin binding GO:0005178 IEA
    integrin binding GO:0005178 ISO
    extracellular matrix structural constituent GO:0005201 IDA
    vitamin D binding GO:0005499 IMP
    calcium ion binding GO:0005509 IEA
    calcium ion binding GO:0005509 ISO
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 IEA
    collagen binding GO:0005518 ISO
    heparin binding GO:0008201 IEA
    heparin binding GO:0008201 ISO
    BMP binding GO:0036122 IEA
    BMP binding GO:0036122 ISO
    proteoglycan binding GO:0043394 ISO
    heparan sulfate proteoglycan binding GO:0043395 IEA
    heparan sulfate proteoglycan binding GO:0043395 ISO
Biological Process
    skeletal system development GO:0001501 ISO
    ossification GO:0001503 ISO
    chondrocyte development GO:0002063 IEA
    chondrocyte development GO:0002063 ISO
    endochondral bone growth GO:0003416 ISO
    growth plate cartilage development GO:0003417 IEA
    growth plate cartilage development GO:0003417 ISO
    apoptotic process GO:0006915 IEA
    apoptotic process GO:0006915 ISO
    response to unfolded protein GO:0006986 IEA
    response to unfolded protein GO:0006986 ISO
    cell adhesion GO:0007155 IEA
    blood coagulation GO:0007596 ISO
    protein secretion GO:0009306 IEA
    protein secretion GO:0009306 ISO
    regulation of gene expression GO:0010468 IEA
    regulation of gene expression GO:0010468 ISO
    vascular associated smooth muscle contraction GO:0014829 IEA
    vascular associated smooth muscle contraction GO:0014829 ISO
    protein processing GO:0016485 IEA
    protein processing GO:0016485 ISO
    collagen fibril organization GO:0030199 IEA
    collagen fibril organization GO:0030199 ISO
    bone mineralization GO:0030282 IEA
    bone mineralization GO:0030282 ISO
    regulation of bone mineralization GO:0030500 IEA
    regulation of bone mineralization GO:0030500 ISO
    BMP signaling pathway GO:0030509 IEA
    BMP signaling pathway GO:0030509 ISO
    multicellular organism growth GO:0035264 IEA
    multicellular organism growth GO:0035264 ISO
    chondrocyte proliferation GO:0035988 IEA
    chondrocyte proliferation GO:0035988 ISO
    tendon development GO:0035989 IEA
    tendon development GO:0035989 ISO
    negative regulation of apoptotic process GO:0043066 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    skin development GO:0043588 IEA
    skin development GO:0043588 ISO
    artery morphogenesis GO:0048844 IEA
    artery morphogenesis GO:0048844 ISO
    musculoskeletal movement GO:0050881 IEA
    musculoskeletal movement GO:0050881 ISO
    neuromuscular process GO:0050905 ISO
    cartilage development GO:0051216 ISO
    protein homooligomerization GO:0051260 IEA
    protein homooligomerization GO:0051260 ISO
    protein homooligomerization GO:0051260 ISS
    muscle cell development GO:0055001 ISO
    limb development GO:0060173 IEA
    limb development GO:0060173 ISO
    limb development GO:0060173 ISO
    bone morphogenesis GO:0060349 ISO
    platelet aggregation GO:0070527 IEA
    platelet aggregation GO:0070527 ISO
    cellular senescence GO:0090398 IEA
    cellular senescence GO:0090398 ISO
    vascular associated smooth muscle cell development GO:0097084 IEA
    vascular associated smooth muscle cell development GO:0097084 ISO
    bone growth GO:0098868 ISO
    negative regulation of hemostasis GO:1900047 IEA
    negative regulation of hemostasis GO:1900047 ISO
    positive regulation of chondrocyte proliferation GO:1902732 IEA
    positive regulation of chondrocyte proliferation GO:1902732 ISO
    cartilage homeostasis GO:1990079 IEA
    cartilage homeostasis GO:1990079 ISO
    cartilage homeostasis GO:1990079 ISS
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular region GO:0005576 ISO
    extracellular region GO:0005576 ISS
    extracellular space GO:0005615 IEA
    extracellular space GO:0005615 ISO
    extracellular matrix GO:0031012 IEA
    extracellular matrix GO:0031012 ISO
    protein-containing complex GO:0032991 IEA
    protein-containing complex GO:0032991 ISO
    collagen-containing extracellular matrix GO:0062023 IBA
    collagen-containing extracellular matrix GO:0062023 IDA
 Experiment description of studies that identified Comp in sEVs
1
Experiment ID 95
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Comp
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Comp is involved
PathwayEvidenceSource
ECM proteoglycans IEA Reactome
Extracellular matrix organization IEA Reactome
Integrin cell surface interactions IEA Reactome





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