Gene description for Lipe
Gene name lipase, hormone sensitive
Gene symbol Lipe
Other names/aliases HSL
Species Rattus norvegicus
 Database cross references - Lipe
ExoCarta ExoCarta_25330
Vesiclepedia VP_25330
Entrez Gene 25330
UniProt P15304  
 Lipe identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Lipe
Molecular Function
    sterol ester esterase activity GO:0004771 IBA
    sterol ester esterase activity GO:0004771 IDA
    sterol ester esterase activity GO:0004771 IEA
    sterol ester esterase activity GO:0004771 ISO
    triacylglycerol lipase activity GO:0004806 IBA
    triacylglycerol lipase activity GO:0004806 IDA
    triacylglycerol lipase activity GO:0004806 IEA
    triacylglycerol lipase activity GO:0004806 ISO
    protein binding GO:0005515 IPI
    lipase activity GO:0016298 IEA
    hydrolase activity, acting on ester bonds GO:0016788 IDA
    serine hydrolase activity GO:0017171 ISO
    protein kinase binding GO:0019901 ISO
    rRNA primary transcript binding GO:0042134 ISS
    monoacylglycerol lipase activity GO:0047372 IDA
    monoacylglycerol lipase activity GO:0047372 IEA
    monoacylglycerol lipase activity GO:0047372 ISO
    all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity GO:0047376 IEA
    retinyl-palmitate esterase activity GO:0050253 IDA
    retinyl-palmitate esterase activity GO:0050253 IEA
    retinyl-palmitate esterase activity GO:0050253 ISO
    diacylglycerol lipase activity GO:0120516 IDA
    diacylglycerol lipase activity GO:0120516 IEA
    diacylglycerol lipase activity GO:0120516 ISO
    diacylglycerol lipase activity GO:0120516 ISS
Biological Process
    transcription initiation at RNA polymerase I promoter GO:0006361 ISS
    termination of RNA polymerase I transcription GO:0006363 ISS
    female pregnancy GO:0007565 IEP
    cholesterol metabolic process GO:0008203 IEA
    response to xenobiotic stimulus GO:0009410 IEP
    lipid catabolic process GO:0016042 ISO
    lipid catabolic process GO:0016042 ISS
    lipid catabolic process GO:0016042 TAS
    triglyceride catabolic process GO:0019433 IBA
    triglyceride catabolic process GO:0019433 IDA
    triglyceride catabolic process GO:0019433 IEA
    triglyceride catabolic process GO:0019433 ISO
    retinol metabolic process GO:0042572 IEA
    long-chain fatty acid catabolic process GO:0042758 ISO
    diacylglycerol catabolic process GO:0046340 ISO
    diacylglycerol catabolic process GO:0046340 ISO
    diacylglycerol catabolic process GO:0046340 ISS
    ether lipid metabolic process GO:0046485 ISO
    ether lipid metabolic process GO:0046485 ISS
    cellular response to cold GO:0070417 ISO
Subcellular Localization
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISS
    mitochondrion GO:0005739 ISS
    lipid droplet GO:0005811 IEA
    lipid droplet GO:0005811 ISO
    lipid droplet GO:0005811 ISS
    lipid droplet GO:0005811 TAS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    cytosol GO:0005829 TAS
    caveola GO:0005901 IEA
    caveola GO:0005901 ISS
    membrane GO:0016020 ISO
    membrane GO:0016020 ISS
 Experiment description of studies that identified Lipe in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Lipe
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Star  
Affinity Capture-Western Rattus norvegicus
Reconstituted Complex Rattus norvegicus
2 Fabp9  
Reconstituted Complex Rattus norvegicus
Two-hybrid Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml
 Pathways in which Lipe is involved
No pathways found





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