Gene description for Lipe
Gene name lipase, hormone sensitive
Gene symbol Lipe
Other names/aliases HSL
Species Rattus norvegicus
 Database cross references - Lipe
ExoCarta ExoCarta_25330
Entrez Gene 25330
UniProt P15304  
 Lipe identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Lipe
Molecular Function
    triglyceride lipase activity GO:0004806 ISO
    rRNA primary transcript binding GO:0042134 ISS
    hormone-sensitive lipase activity GO:0033878 IEA
    acylglycerol lipase activity GO:0047372 IDA
    hydrolase activity, acting on ester bonds GO:0016788 IDA
    protein kinase binding GO:0019901 ISO
    protein binding GO:0005515 IPI
Biological Process
    response to drug GO:0042493 IEP
    cholesterol metabolic process GO:0008203 IEA
    transcription initiation from RNA polymerase I promoter GO:0006361 ISS
    long-chain fatty acid catabolic process GO:0042758 ISO
    diacylglycerol catabolic process GO:0046340 ISO
    female pregnancy GO:0007565 IEP
    triglyceride catabolic process GO:0019433 ISO
    termination of RNA polymerase I transcription GO:0006363 ISS
    lipid catabolic process GO:0016042 TAS
Subcellular Localization
    lipid particle GO:0005811 TAS
    nucleus GO:0005634 ISS
    caveola GO:0005901 ISS
    cytosol GO:0005829 TAS
    mitochondrion GO:0005739 ISS
    cytoplasm GO:0005737 ISS
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified Lipe in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Lipe
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lipe is involved
PathwayEvidenceSource
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis IEA Reactome





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