Gene description for Sod3
Gene name superoxide dismutase 3, extracellular
Gene symbol Sod3
Other names/aliases ECSODPT
Species Rattus norvegicus
 Database cross references - Sod3
ExoCarta ExoCarta_25352
Entrez Gene 25352
UniProt Q08420  
 Sod3 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Sod3
Molecular Function
    copper ion binding GO:0005507 IBA
    superoxide dismutase activity GO:0004784 ISO
    zinc ion binding GO:0008270 IBA
Biological Process
    response to superoxide GO:0000303 TAS
    response to copper ion GO:0046688 IMP
    response to hypoxia GO:0001666 ISO
    response to oxidative stress GO:0006979 IEP
    oxidation-reduction process GO:0055114 ISO
    removal of superoxide radicals GO:0019430 ISO
Subcellular Localization
    trans-Golgi network GO:0005802 ISO
    extracellular exosome GO:0070062 ISO
    extracellular matrix GO:0031012 ISO
    extracellular space GO:0005615 TAS
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Sod3 in exosomes
1
Experiment ID 92
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP70|GAPDH
EV Cytosolic markers
✔
CD9|CD151
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP70|GAPDH
EV Cytosolic markers
✔
CD9|CD151
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Sod3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sod3 is involved
PathwayEvidenceSource
Detoxification of Reactive Oxygen Species IEA Reactome





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