Gene description for Acadvl
Gene name acyl-CoA dehydrogenase, very long chain
Gene symbol Acadvl
Other names/aliases VLCAD
Species Rattus norvegicus
 Database cross references - Acadvl
ExoCarta ExoCarta_25363
Vesiclepedia VP_25363
Entrez Gene 25363
UniProt P45953  
 Acadvl identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Reticulocytes 21828046    
 Gene ontology annotations for Acadvl
Molecular Function
    fatty-acyl-CoA binding GO:0000062 IBA
    fatty-acyl-CoA binding GO:0000062 IDA
    acyl-CoA dehydrogenase activity GO:0003995 IDA
    acyl-CoA dehydrogenase activity GO:0003995 ISO
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 IDA
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 IEA
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 ISO
    very-long-chain fatty acyl-CoA dehydrogenase activity GO:0017099 IBA
    very-long-chain fatty acyl-CoA dehydrogenase activity GO:0017099 IDA
    very-long-chain fatty acyl-CoA dehydrogenase activity GO:0017099 IEA
    very-long-chain fatty acyl-CoA dehydrogenase activity GO:0017099 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    identical protein binding GO:0042802 ISS
    flavin adenine dinucleotide binding GO:0050660 IDA
    flavin adenine dinucleotide binding GO:0050660 IEA
    flavin adenine dinucleotide binding GO:0050660 ISO
Biological Process
    temperature homeostasis GO:0001659 IEA
    temperature homeostasis GO:0001659 ISO
    fatty acid beta-oxidation GO:0006635 IDA
    fatty acid catabolic process GO:0009062 ISO
    response to cold GO:0009409 IEA
    response to cold GO:0009409 ISO
    epithelial cell differentiation GO:0030855 IEA
    epithelial cell differentiation GO:0030855 ISO
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 IEA
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 ISO
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 ISS
    negative regulation of fatty acid biosynthetic process GO:0045717 IEA
    negative regulation of fatty acid biosynthetic process GO:0045717 ISO
    negative regulation of fatty acid oxidation GO:0046322 IEA
    negative regulation of fatty acid oxidation GO:0046322 ISO
    regulation of cholesterol metabolic process GO:0090181 IEA
    regulation of cholesterol metabolic process GO:0090181 ISO
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrial membrane GO:0031966 ISO
    mitochondrial nucleoid GO:0042645 IEA
    mitochondrial nucleoid GO:0042645 ISO
 Experiment description of studies that identified Acadvl in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Acadvl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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