Gene description for Ggh
Gene name gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Gene symbol Ggh
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ggh
ExoCarta ExoCarta_25455
Entrez Gene 25455
UniProt Q62867  
 Ggh identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ggh
Molecular Function
    gamma-glutamyl-peptidase activity GO:0034722 ISS
Biological Process
    response to insulin GO:0032868 IDA
    proteolysis GO:0006508 ISS
    glutamine metabolic process GO:0006541 IEA
    response to drug GO:0042493 IDA
    response to ethanol GO:0045471 IDA
    response to zinc ion GO:0010043 IDA
Subcellular Localization
    melanosome GO:0042470 IEA
    lysosome GO:0005764 TAS
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 TAS
    nucleus GO:0005634 ISO
    cytosol GO:0005829 IDA
 Experiment description of studies that identified Ggh in exosomes
1
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ggh
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ggh is involved
No pathways found





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