Gene description for Gss
Gene name glutathione synthetase
Gene symbol Gss
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Gss
ExoCarta ExoCarta_25458
Entrez Gene 25458
UniProt P46413  
 Gss identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Gss
Molecular Function
    protein homodimerization activity GO:0042803 ISS
    peptide binding GO:0042277 IPI
    glutathione synthase activity GO:0004363 NAS
    ATP binding GO:0005524 ISS
    glutathione binding GO:0043295 ISS
    glycine binding GO:0016594 IDA
    magnesium ion binding GO:0000287 ISS
Biological Process
    response to tumor necrosis factor GO:0034612 IEP
    aging GO:0007568 IEP
    response to nutrient levels GO:0031667 IEP
    glutathione biosynthetic process GO:0006750 ISO
    response to amino acid GO:0043200 IEP
    response to xenobiotic stimulus GO:0009410 IEP
    response to cadmium ion GO:0046686 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Gss in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Gss
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gss is involved
PathwayEvidenceSource
Glutathione synthesis and recycling IEA Reactome





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