Gene description for Irs1
Gene name	insulin receptor substrate 1
Gene symbol	Irs1
Other names/aliases	IRS1IRM
Species	Rattus norvegicus
Database cross references - Irs1
ExoCarta	ExoCarta_25467
Entrez Gene	25467
UniProt	P35570
Irs1 identified in exosomes derived from the following tissue/cell type
Hepatocytes	19367702

Gene ontology annotations for Irs1

Molecular Function     insulin receptor binding GO:0005158 ISS     signal transducer activity GO:0004871 IBA     protein kinase C binding GO:0005080 IPI     protein kinase binding GO:0019901 ISO     protein domain specific binding GO:0019904 IPI     transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 IMP     insulin-like growth factor receptor binding GO:0005159 ISS     SH2 domain binding GO:0042169 IPI     protein binding GO:0005515 IPI     phosphatidylinositol 3-kinase binding GO:0043548 ISO Biological Process     response to insulin GO:0032868 ISO     cellular response to insulin stimulus GO:0032869 ISO     response to peptide hormone GO:0043434 IDA     phosphatidylinositol 3-kinase signaling GO:0014065 ISO     positive regulation of phosphorylation GO:0042327 IDA     negative regulation of somatostatin secretion GO:0090275 IMP     lipid catabolic process GO:0016042 ISO     positive regulation of glucose import in response to insulin stimulus GO:2001275 ISO     positive regulation of glycogen biosynthetic process GO:0045725 ISO     insulin secretion GO:0030073 ISO     positive regulation of glucagon secretion GO:0070094 IMP     protein heterooligomerization GO:0051291 IDA     positive regulation of cell migration GO:0030335 ISO     regulation of gene expression GO:0010468 ISO     mammary gland development GO:0030879 ISO     insulin receptor signaling pathway GO:0008286 ISO     positive regulation of glucose import GO:0046326 ISO     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 ISO     negative regulation of insulin receptor signaling pathway GO:0046627 IMP     protein localization to nucleus GO:0034504 ISO     positive regulation of glucose metabolic process GO:0010907 ISO     insulin-like growth factor receptor signaling pathway GO:0048009 ISS     positive regulation of insulin receptor signaling pathway GO:0046628 IMP     protein kinase B signaling GO:0043491 ISO     negative regulation of insulin secretion GO:0046676 ISO     positive regulation of fatty acid beta-oxidation GO:0032000 ISO     positive regulation of mesenchymal cell proliferation GO:0002053 ISO     response to caffeine GO:0031000 IDA Subcellular Localization     caveola GO:0005901 ISO     nucleus GO:0005634 ISS     intracellular membrane-bounded organelle GO:0043231 ISS     insulin receptor complex GO:0005899 IMP     ciliary basal body GO:0036064 ISO     cytoplasm GO:0005737 ISS     cytosol GO:0005829 TAS     intracellular GO:0005622 ISO     plasma membrane GO:0005886 ISO