Gene description for Irs1
Gene name	insulin receptor substrate 1
Gene symbol	Irs1
Other names/aliases	IRS1IRM
Species	Rattus norvegicus
Database cross references - Irs1
ExoCarta	ExoCarta_25467
Vesiclepedia	VP_25467
Entrez Gene	25467
UniProt	P35570
Irs1 identified in sEVs derived from the following tissue/cell type
Hepatocytes	19367702

Gene ontology annotations for Irs1

Molecular Function     phosphotyrosine residue binding GO:0001784 IEA     phosphotyrosine residue binding GO:0001784 ISO     transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 IMP     transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 ISO     protein kinase C binding GO:0005080 IPI     insulin receptor binding GO:0005158 IBA     insulin receptor binding GO:0005158 IEA     insulin receptor binding GO:0005158 IMP     insulin receptor binding GO:0005158 ISO     insulin receptor binding GO:0005158 ISS     insulin-like growth factor receptor binding GO:0005159 IEA     insulin-like growth factor receptor binding GO:0005159 IPI     insulin-like growth factor receptor binding GO:0005159 ISO     insulin-like growth factor receptor binding GO:0005159 ISS     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IPI     protein kinase binding GO:0019901 ISO     protein domain specific binding GO:0019904 IPI     signaling receptor complex adaptor activity GO:0030159 IEA     signaling receptor complex adaptor activity GO:0030159 ISO     protein-macromolecule adaptor activity GO:0030674 ISO     signaling adaptor activity GO:0035591 ISO     SH2 domain binding GO:0042169 IPI     phosphatidylinositol 3-kinase binding GO:0043548 IBA     phosphatidylinositol 3-kinase binding GO:0043548 IDA     phosphatidylinositol 3-kinase binding GO:0043548 IEA     phosphatidylinositol 3-kinase binding GO:0043548 IMP     phosphatidylinositol 3-kinase binding GO:0043548 IPI     phosphatidylinositol 3-kinase binding GO:0043548 ISO     protein-containing complex binding GO:0044877 IDA     phosphatidylinositol 3-kinase activator activity GO:0141038 ISO Biological Process     positive regulation of mesenchymal cell proliferation GO:0002053 ISO     insulin receptor signaling pathway GO:0008286 IBA     insulin receptor signaling pathway GO:0008286 IDA     insulin receptor signaling pathway GO:0008286 IEA     insulin receptor signaling pathway GO:0008286 ISO     insulin receptor signaling pathway GO:0008286 ISO     regulation of gene expression GO:0010468 ISO     epithelial cell migration GO:0010631 ISO     positive regulation of epithelial cell migration GO:0010634 ISO     positive regulation of glucose metabolic process GO:0010907 ISO     response to activity GO:0014823 IEP     lipid catabolic process GO:0016042 ISO     cell migration GO:0016477 ISO     cytokine-mediated signaling pathway GO:0019221 IEA     cytokine-mediated signaling pathway GO:0019221 ISO     insulin secretion GO:0030073 ISO     mammary gland development GO:0030879 ISO     response to caffeine GO:0031000 IDA     response to caffeine GO:0031000 IEP     positive regulation of fatty acid beta-oxidation GO:0032000 IEA     positive regulation of fatty acid beta-oxidation GO:0032000 ISO     response to insulin GO:0032868 ISO     cellular response to insulin stimulus GO:0032869 ISO     cellular response to insulin stimulus GO:0032869 ISO     protein localization to nucleus GO:0034504 ISO     positive regulation of phosphorylation GO:0042327 IDA     phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IEA     phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 ISO     response to ethanol GO:0045471 IDA     positive regulation of glycogen biosynthetic process GO:0045725 IEA     positive regulation of glycogen biosynthetic process GO:0045725 ISO     positive regulation of D-glucose import GO:0046326 IEA     positive regulation of D-glucose import GO:0046326 ISO     negative regulation of insulin receptor signaling pathway GO:0046627 IMP     positive regulation of insulin receptor signaling pathway GO:0046628 IEA     positive regulation of insulin receptor signaling pathway GO:0046628 IMP     positive regulation of insulin receptor signaling pathway GO:0046628 ISO     negative regulation of insulin secretion GO:0046676 IEA     negative regulation of insulin secretion GO:0046676 IMP     negative regulation of insulin secretion GO:0046676 ISO     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     insulin-like growth factor receptor signaling pathway GO:0048009 ISO     insulin-like growth factor receptor signaling pathway GO:0048009 ISS     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     positive regulation of glucagon secretion GO:0070094 IMP     cellular response to fatty acid GO:0071398 ISO     cellular response to radiation GO:0071478 IEP     negative regulation of somatostatin secretion GO:0090275 IMP     cellular response to angiotensin GO:1904385 IEP     cellular response to brain-derived neurotrophic factor stimulus GO:1990416 IEP Subcellular Localization     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     cytosol GO:0005829 IBA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     insulin receptor complex GO:0005899 IMP     caveola GO:0005901 IEA     caveola GO:0005901 ISO     ciliary basal body GO:0036064 ISO     intracellular membrane-bounded organelle GO:0043231 ISS