Gene description for Lamb2
Gene name laminin, beta 2
Gene symbol Lamb2
Other names/aliases SLAM
Species Rattus norvegicus
 Database cross references - Lamb2
ExoCarta ExoCarta_25473
Vesiclepedia VP_25473
Entrez Gene 25473
UniProt P15800  
 Lamb2 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Lamb2
Molecular Function
    integrin binding GO:0005178 IEA
    integrin binding GO:0005178 ISO
    structural constituent of synapse-associated extracellular matrix GO:0150043 IEA
    structural constituent of synapse-associated extracellular matrix GO:0150043 ISO
Biological Process
    cell morphogenesis GO:0000902 ISO
    cell adhesion GO:0007155 IEA
    axon guidance GO:0007411 IBA
    axon guidance GO:0007411 IEA
    axon guidance GO:0007411 ISO
    neuromuscular junction development GO:0007528 IEA
    neuromuscular junction development GO:0007528 ISO
    visual perception GO:0007601 IEA
    visual perception GO:0007601 ISO
    animal organ morphogenesis GO:0009887 IBA
    tissue development GO:0009888 IBA
    astrocyte development GO:0014002 IEA
    astrocyte development GO:0014002 ISO
    Schwann cell development GO:0014044 IEA
    Schwann cell development GO:0014044 ISO
    cell migration GO:0016477 IBA
    neuron projection development GO:0031175 ISO
    substrate adhesion-dependent cell spreading GO:0034446 IBA
    axon extension involved in regeneration GO:0048677 IEA
    axon extension involved in regeneration GO:0048677 ISO
    synapse organization GO:0050808 ISO
    retina development in camera-type eye GO:0060041 IEA
    retina development in camera-type eye GO:0060041 ISO
    basement membrane assembly GO:0070831 IBA
    metanephric podocyte development GO:0072249 IEA
    metanephric podocyte development GO:0072249 ISO
    metanephric glomerular basement membrane development GO:0072274 IEA
    metanephric glomerular basement membrane development GO:0072274 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    basement membrane GO:0005604 IEA
    basement membrane GO:0005604 ISO
    laminin-3 complex GO:0005608 IEA
    laminin-3 complex GO:0005608 ISO
    neuromuscular junction GO:0031594 IEA
    neuromuscular junction GO:0031594 ISO
    synaptic cleft GO:0043083 IEA
    synaptic cleft GO:0043083 ISO
    laminin complex GO:0043256 IBA
    laminin complex GO:0043256 ISO
    synapse GO:0045202 ISO
 Experiment description of studies that identified Lamb2 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Lamb2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lamb2 is involved
No pathways found





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