Gene description for Ppia
Gene name	peptidylprolyl isomerase A (cyclophilin A)
Gene symbol	Ppia
Other names/aliases	CYCA CyP-A
Species	Rattus norvegicus
Database cross references - Ppia
ExoCarta	ExoCarta_25518
Vesiclepedia	VP_25518
Entrez Gene	25518
UniProt	P10111
Ppia identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041
Cortical neurones	16446100
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Urine	20535238

Gene ontology annotations for Ppia

Molecular Function     peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA     peptidyl-prolyl cis-trans isomerase activity GO:0003755 IEA     peptidyl-prolyl cis-trans isomerase activity GO:0003755 ISO     peptidyl-prolyl cis-trans isomerase activity GO:0003755 ISS     integrin binding GO:0005178 ISO     integrin binding GO:0005178 ISS     cyclosporin A binding GO:0016018 IBA     cyclosporin A binding GO:0016018 IDA     RNA polymerase II CTD heptapeptide repeat P3 isomerase activity GO:0140839 IEA     RNA polymerase II CTD heptapeptide repeat P6 isomerase activity GO:0140840 IEA     heparan sulfate binding GO:1904399 ISO     heparan sulfate binding GO:1904399 ISS Biological Process     protein peptidyl-prolyl isomerization GO:0000413 ISO     protein peptidyl-prolyl isomerization GO:0000413 ISS     negative regulation of protein phosphorylation GO:0001933 ISO     negative regulation of protein phosphorylation GO:0001933 ISS     positive regulation of protein phosphorylation GO:0001934 ISO     positive regulation of protein phosphorylation GO:0001934 ISS     regulation of transcription by RNA polymerase II GO:0006357 IEA     protein folding GO:0006457 IBA     protein folding GO:0006457 IEA     negative regulation of protein kinase activity GO:0006469 ISO     negative regulation of protein kinase activity GO:0006469 ISS     apoptotic process GO:0006915 IEA     apoptotic process GO:0006915 ISO     apoptotic process GO:0006915 ISS     platelet activation GO:0030168 ISO     platelet activation GO:0030168 ISS     neuron differentiation GO:0030182 ISO     neutrophil chemotaxis GO:0030593 ISO     neutrophil chemotaxis GO:0030593 ISS     leukocyte chemotaxis GO:0030595 ISO     leukocyte chemotaxis GO:0030595 ISS     activation of protein kinase B activity GO:0032148 ISO     activation of protein kinase B activity GO:0032148 ISS     negative regulation of stress-activated MAPK cascade GO:0032873 ISO     negative regulation of stress-activated MAPK cascade GO:0032873 ISS     lipid droplet organization GO:0034389 ISO     cellular response to oxidative stress GO:0034599 ISO     cellular response to oxidative stress GO:0034599 ISS     endothelial cell activation GO:0042118 ISO     endothelial cell activation GO:0042118 ISS     positive regulation of MAPK cascade GO:0043410 ISO     positive regulation of MAPK cascade GO:0043410 ISS     regulation of viral genome replication GO:0045069 ISO     regulation of viral genome replication GO:0045069 ISS     positive regulation of viral genome replication GO:0045070 ISO     positive regulation of protein secretion GO:0050714 ISO     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS     cell adhesion molecule production GO:0060352 ISO     cell adhesion molecule production GO:0060352 ISS     negative regulation of protein K48-linked ubiquitination GO:0061944 ISO     negative regulation of protein K48-linked ubiquitination GO:0061944 ISS     platelet aggregation GO:0070527 ISO     platelet aggregation GO:0070527 ISS     negative regulation of calcineurin-mediated signaling GO:0106057 IDA     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 ISO     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 ISS     negative regulation of viral life cycle GO:1903901 ISO     regulation of apoptotic signaling pathway GO:2001233 ISO     regulation of apoptotic signaling pathway GO:2001233 ISS Subcellular Localization     extracellular region GO:0005576 IEA     extracellular region GO:0005576 ISO     extracellular region GO:0005576 ISS     extracellular space GO:0005615 ISO     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     cytosol GO:0005829 ISS     protein-containing complex GO:0032991 ISO