Gene description for Psap
Gene name prosaposin
Gene symbol Psap
Other names/aliases SGP-1
SGP1A
Species Rattus norvegicus
 Database cross references - Psap
ExoCarta ExoCarta_25524
Entrez Gene 25524
UniProt P10960  
 Psap identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Psap
Molecular Function
    G-protein coupled receptor binding GO:0001664 ISO
Biological Process
    regulation of MAPK cascade GO:0043408 ISO
    epithelial cell differentiation involved in prostate gland development GO:0060742 ISO
    cellular response to organic substance GO:0071310 ISO
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 ISO
    regulation of lipid metabolic process GO:0019216 ISO
    negative regulation of hydrogen peroxide-induced cell death GO:1903206 ISO
    prostate gland growth GO:0060736 ISO
    developmental growth GO:0048589 ISO
    sphingolipid metabolic process GO:0006665 IEA
    glycolipid transport GO:0046836 NAS
    positive regulation of MAPK cascade GO:0043410 ISO
Subcellular Localization
    mitochondrion GO:0005739 ISO
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 ISO
    extracellular space GO:0005615 ISO
    Golgi apparatus GO:0005794 ISO
    lysosome GO:0005764 IEA
    extracellular exosome GO:0070062 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Psap in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Psap
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Psap is involved
No pathways found





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