Gene description for Rab12
Gene name RAB12, member RAS oncogene family
Gene symbol Rab12
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Rab12
ExoCarta ExoCarta_25530
Vesiclepedia VP_25530
Entrez Gene 25530
UniProt P35284  
 Rab12 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Rab12
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IEA
    GTP binding GO:0005525 IEA
    GTP binding GO:0005525 TAS
    GDP binding GO:0019003 ISO
    GDP binding GO:0019003 ISS
Biological Process
    exocytosis GO:0006887 IBA
    autophagy GO:0006914 IEA
    endosome to lysosome transport GO:0008333 ISO
    endosome to lysosome transport GO:0008333 ISS
    protein transport GO:0015031 IEA
    positive regulation of macroautophagy GO:0016239 ISO
    protein catabolic process GO:0030163 ISO
    protein catabolic process GO:0030163 ISS
    endocytic recycling GO:0032456 IBA
    Rab protein signal transduction GO:0032482 IEA
    cellular response to type II interferon GO:0071346 ISO
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    lysosome GO:0005764 ISO
    lysosome GO:0005764 ISS
    lysosomal membrane GO:0005765 IEA
    endosome GO:0005768 IBA
    autophagosome GO:0005776 ISO
    plasma membrane GO:0005886 IBA
    synaptic vesicle GO:0008021 IBA
    membrane GO:0016020 IEA
    trans-Golgi network transport vesicle GO:0030140 IBA
    secretory granule GO:0030141 IDA
    phagocytic vesicle GO:0045335 ISO
    recycling endosome membrane GO:0055038 ISO
    recycling endosome membrane GO:0055038 ISS
 Experiment description of studies that identified Rab12 in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Rab12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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