Gene description for Rab12
Gene name RAB12, member RAS oncogene family
Gene symbol Rab12
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Rab12
ExoCarta ExoCarta_25530
Entrez Gene 25530
UniProt P35284  
 Rab12 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Rab12
Molecular Function
    GDP binding GO:0019003 ISS
    GTPase activity GO:0003924 IBA
    GTP binding GO:0005525 TAS
Biological Process
    protein transport GO:0015031 IEA
    autophagy GO:0006914 IEA
    endosome to lysosome transport GO:0008333 ISS
    cellular protein catabolic process GO:0044257 ISS
    vesicle docking involved in exocytosis GO:0006904 IBA
    small GTPase mediated signal transduction GO:0007264 IEA
    positive regulation of macroautophagy GO:0016239 ISO
    regulation of exocytosis GO:0017157 IBA
    intracellular protein transport GO:0006886 IBA
    Rab protein signal transduction GO:0032482 IBA
    protein localization to plasma membrane GO:0072659 IBA
    protein secretion GO:0009306 IBA
    cellular response to insulin stimulus GO:0032869 IBA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    secretory granule GO:0030141 IDA
    recycling endosome membrane GO:0055038 ISS
    autophagosome GO:0005776 ISO
    Golgi apparatus GO:0005794 IBA
    cell GO:0005623 ISO
    endosome membrane GO:0010008 IBA
    lysosome GO:0005764 ISS
    intracellular GO:0005622 ISO
    insulin-responsive compartment GO:0032593 IBA
    lysosomal membrane GO:0005765 IEA
 Experiment description of studies that identified Rab12 in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Rab12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rab12 is involved
No pathways found





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