Gene description for Rab3a
Gene name RAB3A, member RAS oncogene family
Gene symbol Rab3a
Other names/aliases RAB3
Species Rattus norvegicus
 Database cross references - Rab3a
ExoCarta ExoCarta_25531
Vesiclepedia VP_25531
Entrez Gene 25531
UniProt P63012  
 Rab3a identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Rab3a
Molecular Function
    ATPase activator activity GO:0001671 IDA
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IEA
    GTPase activity GO:0003924 ISO
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IDA
    GTP binding GO:0005525 IEA
    protein-macromolecule adaptor activity GO:0030674 IEA
    protein-macromolecule adaptor activity GO:0030674 ISO
    GTP-dependent protein binding GO:0030742 IEA
    GTP-dependent protein binding GO:0030742 ISO
    myosin V binding GO:0031489 IBA
    myosin V binding GO:0031489 IEA
    myosin V binding GO:0031489 ISO
    GDP-dissociation inhibitor binding GO:0051021 IPI
    ATPase binding GO:0051117 IPI
Biological Process
    plasma membrane repair GO:0001778 IEA
    plasma membrane repair GO:0001778 ISO
    respiratory system process GO:0003016 IEA
    respiratory system process GO:0003016 ISO
    intracellular protein transport GO:0006886 IEA
    exocytosis GO:0006887 ISO
    mitochondrion organization GO:0007005 IEA
    mitochondrion organization GO:0007005 ISO
    neuromuscular synaptic transmission GO:0007274 IEA
    neuromuscular synaptic transmission GO:0007274 ISO
    axonogenesis GO:0007409 IBA
    axonogenesis GO:0007409 IEA
    axonogenesis GO:0007409 ISO
    post-embryonic development GO:0009791 IEA
    post-embryonic development GO:0009791 ISO
    regulation of synaptic vesicle priming GO:0010807 IDA
    regulation of dopamine secretion GO:0014059 IDA
    synaptic vesicle exocytosis GO:0016079 IBA
    synaptic vesicle exocytosis GO:0016079 IEA
    synaptic vesicle exocytosis GO:0016079 IMP
    synaptic vesicle exocytosis GO:0016079 ISO
    synaptic vesicle maturation GO:0016188 IEA
    synaptic vesicle maturation GO:0016188 ISO
    calcium-ion regulated exocytosis GO:0017156 ISO
    regulation of exocytosis GO:0017157 ISO
    insulin secretion GO:0030073 IEA
    insulin secretion GO:0030073 ISO
    lung development GO:0030324 IEA
    lung development GO:0030324 ISO
    regulation of synaptic vesicle fusion to presynaptic active zone membrane GO:0031630 IEA
    regulation of synaptic vesicle fusion to presynaptic active zone membrane GO:0031630 ISO
    regulation of synaptic vesicle fusion to presynaptic active zone membrane GO:0031630 ISO
    regulation of synaptic vesicle fusion to presynaptic active zone membrane GO:0031630 ISS
    lysosome localization GO:0032418 IEA
    lysosome localization GO:0032418 ISO
    Rab protein signal transduction GO:0032482 IC
    synaptic vesicle recycling GO:0036465 IMP
    regulated exocytosis GO:0045055 ISO
    regulation of short-term neuronal synaptic plasticity GO:0048172 IEA
    regulation of short-term neuronal synaptic plasticity GO:0048172 ISO
    regulation of short-term neuronal synaptic plasticity GO:0048172 ISS
    synaptic vesicle transport GO:0048489 IEA
    synaptic vesicle transport GO:0048489 ISO
    maintenance of presynaptic active zone structure GO:0048790 IEA
    maintenance of presynaptic active zone structure GO:0048790 ISO
    sensory perception of touch GO:0050975 IEA
    sensory perception of touch GO:0050975 ISO
    response to electrical stimulus GO:0051602 IEA
    response to electrical stimulus GO:0051602 ISO
    establishment of localization in cell GO:0051649 ISO
    acrosomal vesicle exocytosis GO:0060478 IBA
    acrosomal vesicle exocytosis GO:0060478 IEA
    acrosomal vesicle exocytosis GO:0060478 ISO
    evoked neurotransmitter secretion GO:0061670 IEA
    evoked neurotransmitter secretion GO:0061670 ISO
    synaptic vesicle clustering GO:0097091 IEA
    synaptic vesicle clustering GO:0097091 ISO
    regulation of presynaptic dense core granule exocytosis GO:0099161 IEA
    regulation of presynaptic dense core granule exocytosis GO:0099161 ISO
    positive regulation of regulated secretory pathway GO:1903307 IEA
    positive regulation of regulated secretory pathway GO:1903307 ISO
    regulation of plasma membrane repair GO:1905684 IEA
    regulation of plasma membrane repair GO:1905684 ISO
    regulation of synaptic vesicle exocytosis GO:2000300 IDA
Subcellular Localization
    acrosomal vesicle GO:0001669 IEA
    acrosomal vesicle GO:0001669 ISO
    lysosome GO:0005764 IEA
    endosome GO:0005768 IBA
    endosome GO:0005768 IEA
    endosome GO:0005768 ISO
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    synaptic vesicle GO:0008021 IBA
    synaptic vesicle GO:0008021 IDA
    synaptic vesicle GO:0008021 ISO
    secretory granule GO:0030141 IDA
    axon GO:0030424 IBA
    axon GO:0030424 IDA
    synaptic vesicle membrane GO:0030672 EXP
    synaptic vesicle membrane GO:0030672 IBA
    synaptic vesicle membrane GO:0030672 IDA
    synaptic vesicle membrane GO:0030672 IDA
    synaptic vesicle membrane GO:0030672 IEA
    synaptic vesicle membrane GO:0030672 ISO
    protein-containing complex GO:0032991 IDA
    terminal bouton GO:0043195 IDA
    terminal bouton GO:0043195 IEA
    terminal bouton GO:0043195 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
    presynaptic active zone GO:0048786 IEA
    presynaptic active zone GO:0048786 ISO
    presynaptic active zone GO:0048786 ISS
    presynapse GO:0098793 ISO
    postsynapse GO:0098794 IEA
    postsynapse GO:0098794 ISO
    postsynapse GO:0098794 ISS
 Experiment description of studies that identified Rab3a in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Rab3a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rph3al  
Reconstituted Complex Rattus norvegicus
2 STXBP5L  
Affinity Capture-MS Homo sapiens
3 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
4 Rims2  
Reconstituted Complex Rattus norvegicus
View the network image/svg+xml



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