Gene description for Rab3a
Gene name RAB3A, member RAS oncogene family
Gene symbol Rab3a
Other names/aliases RAB3
Species Rattus norvegicus
 Database cross references - Rab3a
ExoCarta ExoCarta_25531
Entrez Gene 25531
UniProt P63012  
 Rab3a identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Rab3a
Molecular Function
    GTP binding GO:0005525 IDA
    protein binding GO:0005515 IPI
    GTPase activity GO:0003924 ISO
    GTPase binding GO:0051020 IPI
    protein C-terminus binding GO:0008022 IPI
    ATPase binding GO:0051117 IDA
    myosin V binding GO:0031489 ISO
    ATPase activator activity GO:0001671 IDA
Biological Process
    sensory perception of touch GO:0050975 ISO
    metabolic process GO:0008152 ISO
    intracellular protein transport GO:0006886 IBA
    synaptic vesicle recycling GO:0036465 IMP
    protein localization to plasma membrane GO:0072659 IBA
    Rab protein signal transduction GO:0032482 IC
    regulation of synaptic vesicle fusion to presynaptic membrane GO:0031630 ISS
    evoked neurotransmitter secretion GO:0061670 ISO
    post-embryonic development GO:0009791 ISO
    regulation of short-term neuronal synaptic plasticity GO:0048172 ISS
    vesicle docking involved in exocytosis GO:0006904 IBA
    positive regulation of regulated secretory pathway GO:1903307 ISO
    synaptic vesicle maturation GO:0016188 ISO
    synaptic vesicle exocytosis GO:0016079 ISO
    positive regulation of ATPase activity GO:0032781 IDA
    neuromuscular synaptic transmission GO:0007274 ISO
    maintenance of presynaptic active zone structure GO:0048790 ISO
    axonogenesis GO:0007409 ISO
    response to electrical stimulus GO:0051602 ISO
    regulation of exocytosis GO:0017157 ISO
    mitochondrion organization GO:0007005 ISO
    respiratory system process GO:0003016 ISO
    protein secretion GO:0009306 IBA
    lung development GO:0030324 ISO
Subcellular Localization
    cell GO:0005623 ISO
    extracellular vesicle GO:1903561 ISO
    cytosol GO:0005829 IDA
    protein complex GO:0043234 IDA
    axon GO:0030424 IDA
    plasma membrane GO:0005886 IBA
    intracellular organelle GO:0043229 IDA
    terminal bouton GO:0043195 ISO
    secretory granule membrane GO:0030667 IBA
    acrosomal vesicle GO:0001669 ISO
    synaptic vesicle GO:0008021 ISO
    membrane GO:0016020 IDA
    endosome GO:0005768 ISO
 Experiment description of studies that identified Rab3a in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Rab3a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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