Gene description for Slc1a1
Gene name solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Gene symbol Slc1a1
Other names/aliases Eaac1
Eaat3
REAAC1
Species Rattus norvegicus
 Database cross references - Slc1a1
ExoCarta ExoCarta_25550
Entrez Gene 25550
UniProt P51907  
 Slc1a1 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Slc1a1
Molecular Function
    protein binding GO:0005515 IPI
    cysteine transmembrane transporter activity GO:0033229 ISS
    glutamate binding GO:0016595 IDA
    L-glutamate transmembrane transporter activity GO:0005313 ISO
    glutamate:sodium symporter activity GO:0015501 ISO
    sodium:dicarboxylate symporter activity GO:0017153 IEA
Biological Process
    cysteine transport GO:0042883 ISS
    L-glutamate transport GO:0015813 ISO
    protein homooligomerization GO:0051260 ISO
    D-aspartate import GO:0070779 ISO
    L-glutamate import GO:0051938 ISO
    cysteine transmembrane transport GO:1903712 ISS
    L-glutamate transmembrane transport GO:0089711 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISS
    extracellular exosome GO:0070062 ISO
    integral component of membrane GO:0016021 IEA
    apical plasma membrane GO:0016324 ISS
 Experiment description of studies that identified Slc1a1 in exosomes
1
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc1a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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