Gene description for Slc6a4
Gene name solute carrier family 6 (neurotransmitter transporter), member 4
Gene symbol Slc6a4
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Slc6a4
ExoCarta ExoCarta_25553
Entrez Gene 25553
UniProt P31652  
 Slc6a4 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Slc6a4
Molecular Function
    monoamine transmembrane transporter activity GO:0008504 ISO
    Rab GTPase binding GO:0017137 ISO
    protein homodimerization activity GO:0042803 IMP
    serotonin:sodium symporter activity GO:0005335 ISS
    serotonin transmembrane transporter activity GO:0015222 TAS
    protein binding GO:0005515 IPI
    syntaxin-1 binding GO:0017075 IPI
    nitric-oxide synthase binding GO:0050998 ISO
    actin filament binding GO:0051015 IDA
    myosin binding GO:0017022 IPI
    cocaine binding GO:0019811 IMP
Biological Process
    monoamine transport GO:0015844 ISO
    response to nutrient GO:0007584 IEP
    negative regulation of cerebellar granule cell precursor proliferation GO:0021941 IMP
    brain morphogenesis GO:0048854 ISO
    brain development GO:0007420 IEP
    sperm ejaculation GO:0042713 IMP
    serotonin transport GO:0006837 TAS
    response to estradiol GO:0032355 IEP
    memory GO:0007613 IMP
    vasoconstriction GO:0042310 IMP
    cellular response to cGMP GO:0071321 IDA
    negative regulation of organ growth GO:0046621 ISO
    positive regulation of cell cycle GO:0045787 ISO
    negative regulation of neuron differentiation GO:0045665 IMP
    response to toxic substance GO:0009636 ISO
    response to hypoxia GO:0001666 IEP
    protein oligomerization GO:0051259 IDA
    positive regulation of gene expression GO:0010628 ISO
    locomotory behavior GO:0007626 NAS
    serotonin uptake GO:0051610 ISO
    response to organic substance GO:0010033 IEP
    transmembrane transport GO:0055085 IEA
    social behavior GO:0035176 ISO
    thalamus development GO:0021794 ISO
    negative regulation of synaptic transmission, dopaminergic GO:0032227 IMP
    cellular response to retinoic acid GO:0071300 IEP
    cellular response to organic substance GO:0071310 ISO
    circadian rhythm GO:0007623 IMP
    protein homooligomerization GO:0051260 IDA
    response to drug GO:0042493 IEP
Subcellular Localization
    integral component of plasma membrane GO:0005887 IEA
    neuron projection GO:0043005 IDA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 ISO
    endosome membrane GO:0010008 IEA
    membrane raft GO:0045121 ISO
    endomembrane system GO:0012505 NAS
 Experiment description of studies that identified Slc6a4 in exosomes
1
Experiment ID 97
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc6a4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc6a4 is involved
No pathways found





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