Gene description for Map3k12
Gene name mitogen activated protein kinase kinase kinase 12
Gene symbol Map3k12
Other names/aliases DLK
MUK
PK
Zpk
Species Rattus norvegicus
 Database cross references - Map3k12
ExoCarta ExoCarta_25579
Entrez Gene 25579
UniProt Q63796  
 Map3k12 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Map3k12
Molecular Function
    ATP binding GO:0005524 IEA
    protein serine/threonine kinase activity GO:0004674 ISS
    protein kinase binding GO:0019901 ISO
    protein homodimerization activity GO:0042803 ISS
    MAP kinase kinase kinase activity GO:0004709 IEA
Biological Process
    activation of MAPKK activity GO:0000186 IEA
    JNK cascade GO:0007254 IEA
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 ISO
    peptidyl-threonine phosphorylation GO:0018107 ISS
    protein autophosphorylation GO:0046777 ISS
    peptidyl-serine phosphorylation GO:0018105 ISS
    protein phosphorylation GO:0006468 ISS
    histone phosphorylation GO:0016572 ISS
Subcellular Localization
    axon GO:0030424 ISO
    growth cone GO:0030426 ISO
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 ISS
 Experiment description of studies that identified Map3k12 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Map3k12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Map3k12 is involved
No pathways found





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