Gene description for Krt8
Gene name keratin 8, type II
Gene symbol Krt8
Other names/aliases CYKER
Krt2-8
Species Rattus norvegicus
 Database cross references - Krt8
ExoCarta ExoCarta_25626
Entrez Gene 25626
UniProt Q10758  
 Krt8 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Krt8
Molecular Function
    protein complex binding GO:0032403 IPI
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
    scaffold protein binding GO:0097110 ISO
Biological Process
    sarcomere organization GO:0045214 IDA
    cell differentiation involved in embryonic placenta development GO:0060706 ISO
    response to hydrostatic pressure GO:0051599 IDA
    extrinsic apoptotic signaling pathway GO:0097191 ISO
    hepatocyte apoptotic process GO:0097284 ISO
    tumor necrosis factor-mediated signaling pathway GO:0033209 ISO
    response to other organism GO:0051707 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    intermediate filament cytoskeleton GO:0045111 ISO
    nuclear matrix GO:0016363 IEA
    nucleus GO:0005634 ISO
    cell-cell junction GO:0005911 ISO
    sarcolemma GO:0042383 ISO
    extracellular exosome GO:0070062 ISO
    dystrophin-associated glycoprotein complex GO:0016010 IDA
    keratin filament GO:0045095 IDA
    costamere GO:0043034 IDA
    nucleoplasm GO:0005654 IEA
    Z disc GO:0030018 ISO
    intermediate filament GO:0005882 ISO
    cell periphery GO:0071944 ISO
 Experiment description of studies that identified Krt8 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Krt8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Krt8 is involved
No pathways found





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