Gene description for Krt8
Gene name keratin 8, type II
Gene symbol Krt8
Other names/aliases CYKER
Species Rattus norvegicus
 Database cross references - Krt8
ExoCarta ExoCarta_25626
Entrez Gene 25626
UniProt Q10758  
 Krt8 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Krt8
Molecular Function
    protein complex binding GO:0032403 IPI
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
    scaffold protein binding GO:0097110 ISO
Biological Process
    sarcomere organization GO:0045214 IDA
    cell differentiation involved in embryonic placenta development GO:0060706 ISO
    response to hydrostatic pressure GO:0051599 IDA
    extrinsic apoptotic signaling pathway GO:0097191 ISO
    hepatocyte apoptotic process GO:0097284 ISO
    tumor necrosis factor-mediated signaling pathway GO:0033209 ISO
    response to other organism GO:0051707 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    intermediate filament cytoskeleton GO:0045111 ISO
    nuclear matrix GO:0016363 IEA
    nucleus GO:0005634 ISO
    cell-cell junction GO:0005911 ISO
    sarcolemma GO:0042383 ISO
    extracellular exosome GO:0070062 ISO
    dystrophin-associated glycoprotein complex GO:0016010 IDA
    keratin filament GO:0045095 IDA
    costamere GO:0043034 IDA
    nucleoplasm GO:0005654 IEA
    Z disc GO:0030018 ISO
    intermediate filament GO:0005882 ISO
    cell periphery GO:0071944 ISO
 Experiment description of studies that identified Krt8 in exosomes
Experiment ID 225
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Krt8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Krt8 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here