Gene description for Khk
Gene name ketohexokinase
Gene symbol Khk
Other names/aliases KETHPRO
Species Rattus norvegicus
 Database cross references - Khk
ExoCarta ExoCarta_25659
Entrez Gene 25659
UniProt Q02974  
 Khk identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Khk
Molecular Function
    fructokinase activity GO:0008865 ISO
    ATP binding GO:0005524 IEA
    ketohexokinase activity GO:0004454 TAS
Biological Process
    fructose metabolic process GO:0006000 ISO
    response to zinc ion GO:0010043 IDA
    response to sucrose GO:0009744 IDA
    regulation of glycogen metabolic process GO:0070873 ISO
    response to glucose GO:0009749 IDA
    response to insulin GO:0032868 IDA
    carbohydrate phosphorylation GO:0046835 ISO
    response to fructose GO:0009750 IEP
    carbohydrate catabolic process GO:0016052 TAS
Subcellular Localization
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    cellular_component GO:0005575 ND
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Khk in exosomes
Experiment ID 192
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Khk
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Khk is involved
No pathways found

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