Gene description for Khk
Gene name ketohexokinase
Gene symbol Khk
Other names/aliases KETHPRO
Species Rattus norvegicus
 Database cross references - Khk
ExoCarta ExoCarta_25659
Vesiclepedia VP_25659
Entrez Gene 25659
UniProt Q02974  
 Khk identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Khk
Molecular Function
    ketohexokinase activity GO:0004454 IBA
    ketohexokinase activity GO:0004454 IDA
    ketohexokinase activity GO:0004454 IEA
    ketohexokinase activity GO:0004454 ISO
    ketohexokinase activity GO:0004454 TAS
    ATP binding GO:0005524 IEA
    ATP binding GO:0005524 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    fructose binding GO:0070061 IEA
    fructose binding GO:0070061 ISO
Biological Process
    fructose metabolic process GO:0006000 IBA
    fructose metabolic process GO:0006000 IDA
    fructose metabolic process GO:0006000 IEA
    fructose metabolic process GO:0006000 ISO
    fructose metabolic process GO:0006000 ISO
    fructose catabolic process GO:0006001 ISO
    response to sucrose GO:0009744 IBA
    response to sucrose GO:0009744 IDA
    response to glucose GO:0009749 IBA
    response to glucose GO:0009749 IDA
    response to fructose GO:0009750 IBA
    response to fructose GO:0009750 IEP
    response to zinc ion GO:0010043 IBA
    response to zinc ion GO:0010043 IDA
    carbohydrate catabolic process GO:0016052 TAS
    response to insulin GO:0032868 IBA
    response to insulin GO:0032868 IDA
    carbohydrate phosphorylation GO:0046835 IEA
    fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate GO:0061624 ISO
    regulation of glycogen metabolic process GO:0070873 IBA
    regulation of glycogen metabolic process GO:0070873 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Khk in exosomes
1
Experiment ID 192
MISEV standards
CEM
Biophysical techniques
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Khk
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Khk is involved
PathwayEvidenceSource
Fructose catabolism IEA Reactome
Fructose metabolism IEA Reactome
Metabolism IEA Reactome
Metabolism of carbohydrates IEA Reactome





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