Gene description for Fn1
Gene name fibronectin 1
Gene symbol Fn1
Other names/aliases FIBNEC
fn-1
Species Rattus norvegicus
 Database cross references - Fn1
ExoCarta ExoCarta_25661
Vesiclepedia VP_25661
Entrez Gene 25661
 Fn1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Fn1
Molecular Function
    protease binding GO:0002020 IEA
    protease binding GO:0002020 IPI
    protease binding GO:0002020 ISO
    signaling receptor binding GO:0005102 ISO
    integrin binding GO:0005178 IBA
    integrin binding GO:0005178 IEA
    integrin binding GO:0005178 ISO
    extracellular matrix structural constituent GO:0005201 TAS
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IEA
    peptidase activator activity GO:0016504 IEA
    peptidase activator activity GO:0016504 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    proteoglycan binding GO:0043394 IBA
    proteoglycan binding GO:0043394 IEA
    proteoglycan binding GO:0043394 ISO
    mercury ion binding GO:0045340 IDA
    receptor ligand activity GO:0048018 IEA
    receptor ligand activity GO:0048018 ISO
Biological Process
    ossification GO:0001503 TAS
    angiogenesis GO:0001525 IEA
    regulation of protein phosphorylation GO:0001932 ISO
    response to ischemia GO:0002931 IEP
    acute-phase response GO:0006953 IEA
    cell-substrate junction assembly GO:0007044 IBA
    cell-substrate junction assembly GO:0007044 IEA
    cell-substrate junction assembly GO:0007044 ISO
    cell adhesion GO:0007155 IEA
    cell adhesion GO:0007155 ISO
    cell-matrix adhesion GO:0007160 IBA
    cell-matrix adhesion GO:0007160 IMP
    cell-matrix adhesion GO:0007160 ISO
    calcium-independent cell-matrix adhesion GO:0007161 IEA
    calcium-independent cell-matrix adhesion GO:0007161 ISO
    integrin-mediated signaling pathway GO:0007229 IEA
    integrin-mediated signaling pathway GO:0007229 ISO
    nervous system development GO:0007399 IBA
    heart development GO:0007507 IBA
    positive regulation of cell population proliferation GO:0008284 ISO
    glial cell migration GO:0008347 IDA
    regulation of cell shape GO:0008360 IEA
    response to xenobiotic stimulus GO:0009410 IEP
    response to iron ion GO:0010039 IEP
    response to ozone GO:0010193 IEP
    positive regulation of gene expression GO:0010628 IEA
    positive regulation of gene expression GO:0010628 ISO
    response to activity GO:0014823 IEP
    response to muscle activity GO:0014850 IEA
    response to muscle activity GO:0014850 ISO
    peptide cross-linking GO:0018149 ISO
    extracellular matrix organization GO:0030198 IMP
    positive regulation of cell migration GO:0030335 IMP
    negative regulation of collagen biosynthetic process GO:0032966 IMP
    integrin activation GO:0033622 IEA
    integrin activation GO:0033622 ISO
    substrate adhesion-dependent cell spreading GO:0034446 IEA
    substrate adhesion-dependent cell spreading GO:0034446 ISO
    cellular response to vascular endothelial growth factor stimulus GO:0035924 IEP
    endodermal cell differentiation GO:0035987 IEA
    endodermal cell differentiation GO:0035987 ISO
    cellular response to platelet-derived growth factor stimulus GO:0036120 IEP
    wound healing GO:0042060 IEA
    wound healing GO:0042060 ISO
    negative regulation of apoptotic process GO:0043066 IMP
    positive regulation of axon extension GO:0045773 IEA
    positive regulation of axon extension GO:0045773 ISO
    positive regulation of fibroblast proliferation GO:0048146 IEA
    positive regulation of fibroblast proliferation GO:0048146 ISO
    positive regulation of chemotaxis GO:0050921 IDA
    response to glucocorticoid GO:0051384 IEP
    biological process involved in interaction with symbiont GO:0051702 IEA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO
    regulation of ERK1 and ERK2 cascade GO:0070372 IEA
    regulation of ERK1 and ERK2 cascade GO:0070372 ISO
    cellular response to lipopolysaccharide GO:0071222 IEP
    cellular response to mercury ion GO:0071288 IDA
    cellular response to glucose stimulus GO:0071333 IEP
    cellular response to interleukin-1 GO:0071347 IMP
    cellular response to prostaglandin E stimulus GO:0071380 IEP
    cellular response to transforming growth factor beta stimulus GO:0071560 IEP
    negative regulation of transforming growth factor beta production GO:0071635 IEA
    negative regulation of transforming growth factor beta production GO:0071635 ISO
    cellular response to BMP stimulus GO:0071773 IEP
    negative regulation of monocyte activation GO:0150102 IEA
    negative regulation of monocyte activation GO:0150102 ISO
    neural crest cell migration involved in autonomic nervous system development GO:1901166 IEA
    neural crest cell migration involved in autonomic nervous system development GO:1901166 ISO
    positive regulation of substrate-dependent cell migration, cell attachment to substrate GO:1904237 IEA
    positive regulation of substrate-dependent cell migration, cell attachment to substrate GO:1904237 ISO
    cellular response to angiotensin GO:1904385 IEP
    cellular response to amyloid-beta GO:1904646 IEP
Subcellular Localization
    fibrinogen complex GO:0005577 IEA
    fibrinogen complex GO:0005577 ISO
    basement membrane GO:0005604 IDA
    basement membrane GO:0005604 IEA
    basement membrane GO:0005604 ISO
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 IEA
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISO
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IEA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISO
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
    extracellular matrix GO:0031012 ISO
    extracellular matrix GO:0031012 ISO
    collagen-containing extracellular matrix GO:0062023 IEA
    collagen-containing extracellular matrix GO:0062023 ISO
    extracellular exosome GO:0070062 IEA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Fn1 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Fn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fn1 is involved
No pathways found





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