Gene description for Ahr
Gene name aryl hydrocarbon receptor
Gene symbol Ahr
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ahr
ExoCarta ExoCarta_25690
Entrez Gene 25690
UniProt P41738  
 Ahr identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Ahr
Molecular Function
    enhancer binding GO:0035326 ISO
    transcription factor binding GO:0008134 ISO
    E-box binding GO:0070888 ISS
    transcription regulatory region DNA binding GO:0044212 ISO
    protein heterodimerization activity GO:0046982 ISO
    protein binding GO:0005515 IPI
    protein dimerization activity GO:0046983 IEA
    ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0004879 ISO
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
    Hsp90 protein binding GO:0051879 ISO
    sequence-specific DNA binding GO:0043565 ISO
    signal transducer activity GO:0004871 IEA
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0003705 ISO
    aryl hydrocarbon receptor activity GO:0004874 TAS
    DNA binding GO:0003677 TAS
Biological Process
    camera-type eye development GO:0043010 ISO
    apoptotic process GO:0006915 TAS
    venous blood vessel development GO:0060841 ISO
    embryonic hemopoiesis GO:0035162 ISO
    T cell homeostasis GO:0043029 ISO
    blood vessel development GO:0001568 ISO
    response to xenobiotic stimulus GO:0009410 TAS
    response to organic cyclic compound GO:0014070 IMP
    negative regulation of systemic arterial blood pressure GO:0003085 ISO
    circumferential growth involved in left ventricle morphogenesis GO:0003243 ISO
    kidney morphogenesis GO:0060993 ISO
    smooth muscle tissue development GO:0048745 ISO
    circadian regulation of gene expression GO:0032922 ISS
    positive regulation of cell size GO:0045793 ISO
    regulation of transcription from RNA polymerase II promoter GO:0006357 ISO
    response to estradiol GO:0032355 IEP
    cellular response to cAMP GO:0071320 ISO
    response to toxic substance GO:0009636 ISO
    B cell homeostasis GO:0001782 ISO
    reproductive structure development GO:0048608 ISO
    lymphocyte homeostasis GO:0002260 ISO
    blood vessel remodeling GO:0001974 ISO
    blood circulation GO:0008015 ISO
    gland development GO:0048732 ISO
    glomerulus morphogenesis GO:0072102 ISO
    positive regulation of growth GO:0045927 ISO
    blood vessel morphogenesis GO:0048514 ISO
    regulation of B cell proliferation GO:0030888 ISO
    negative regulation of necrotic cell death GO:0060547 ISO
    immune system process GO:0002376 ISO
    liver development GO:0001889 ISO
    cardiac left ventricle morphogenesis GO:0003214 ISO
    regulation of gene expression GO:0010468 ISO
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    regulation of transcription, DNA-templated GO:0006355 ISO
    intracellular receptor signaling pathway GO:0030522 TAS
    common bile duct development GO:0061009 ISO
    cell morphogenesis GO:0000902 ISO
    transcription from RNA polymerase II promoter GO:0006366 ISO
    prostate gland development GO:0030850 ISO
    positive regulation of transcription, DNA-templated GO:0045893 ISS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IBA
    cellular response to glucocorticoid stimulus GO:0071385 IEP
    patterning of blood vessels GO:0001569 ISO
    spleen development GO:0048536 ISO
    negative regulation of vasoconstriction GO:0045906 ISO
    regulation of blood vessel size GO:0050880 ISO
    positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    ovarian follicle development GO:0001541 IMP
    post-embryonic hemopoiesis GO:0035166 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 TAS
    nucleoplasm GO:0005654 ISO
    nuclear aryl hydrocarbon receptor complex GO:0034753 IBA
 Experiment description of studies that identified Ahr in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Ahr
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ahr is involved
No pathways found





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