Gene description for Slc11a2
Gene name	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
Gene symbol	Slc11a2
Other names/aliases	Dmt1 Nramp2
Species	Rattus norvegicus
Database cross references - Slc11a2
ExoCarta	ExoCarta_25715
Vesiclepedia	VP_25715
Entrez Gene	25715
UniProt	O54902
Slc11a2 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Slc11a2

Molecular Function     copper ion transmembrane transporter activity GO:0005375 IDA     copper ion transmembrane transporter activity GO:0005375 IEA     copper ion transmembrane transporter activity GO:0005375 ISO     iron ion transmembrane transporter activity GO:0005381 IDA     manganese ion transmembrane transporter activity GO:0005384 IBA     manganese ion transmembrane transporter activity GO:0005384 IDA     manganese ion transmembrane transporter activity GO:0005384 IEA     manganese ion transmembrane transporter activity GO:0005384 ISO     zinc ion transmembrane transporter activity GO:0005385 ISO     zinc ion transmembrane transporter activity GO:0005385 ISO     iron ion binding GO:0005506 IDA     copper ion binding GO:0005507 IDA     zinc ion binding GO:0008270 IDA     calcium ion transmembrane transporter activity GO:0015085 ISO     cadmium ion transmembrane transporter activity GO:0015086 IBA     cadmium ion transmembrane transporter activity GO:0015086 IDA     cadmium ion transmembrane transporter activity GO:0015086 IEA     cadmium ion transmembrane transporter activity GO:0015086 ISO     cobalt ion transmembrane transporter activity GO:0015087 IBA     cobalt ion transmembrane transporter activity GO:0015087 IDA     cobalt ion transmembrane transporter activity GO:0015087 IEA     cobalt ion transmembrane transporter activity GO:0015087 ISO     ferrous iron transmembrane transporter activity GO:0015093 IBA     ferrous iron transmembrane transporter activity GO:0015093 IEA     ferrous iron transmembrane transporter activity GO:0015093 IMP     ferrous iron transmembrane transporter activity GO:0015093 ISO     ferrous iron transmembrane transporter activity GO:0015093 ISS     lead ion transmembrane transporter activity GO:0015094 IBA     lead ion transmembrane transporter activity GO:0015094 IDA     lead ion transmembrane transporter activity GO:0015094 IEA     lead ion transmembrane transporter activity GO:0015094 ISO     nickel cation transmembrane transporter activity GO:0015099 IBA     nickel cation transmembrane transporter activity GO:0015099 IDA     nickel cation transmembrane transporter activity GO:0015099 ISO     vanadium ion transmembrane transporter activity GO:0015100 ISO     solute:proton symporter activity GO:0015295 IEA     solute:proton symporter activity GO:0015295 ISO     nickel cation binding GO:0016151 IDA     inorganic cation transmembrane transporter activity GO:0022890 ISO     manganese ion binding GO:0030145 IDA     cadmium ion binding GO:0046870 IBA     cadmium ion binding GO:0046870 IDA     cadmium ion binding GO:0046870 IEA     cadmium ion binding GO:0046870 ISO     transition metal ion transmembrane transporter activity GO:0046915 IEA     transition metal ion transmembrane transporter activity GO:0046915 ISO     cobalt ion binding GO:0050897 IDA     chromium ion transmembrane transporter activity GO:0070835 ISO     retromer complex binding GO:1905394 ISO Biological Process     transition metal ion transport GO:0000041 IDA     response to hypoxia GO:0001666 IEP     response to hypoxia GO:0001666 ISO     detection of oxygen GO:0003032 ISO     detection of oxygen GO:0003032 ISO     porphyrin-containing compound metabolic process GO:0006778 ISO     porphyrin-containing compound biosynthetic process GO:0006779 ISO     heme biosynthetic process GO:0006783 IEA     heme biosynthetic process GO:0006783 ISO     cobalt ion transport GO:0006824 IEA     cobalt ion transport GO:0006824 ISO     cobalt ion transport GO:0006824 ISO     copper ion transport GO:0006825 ISO     iron ion transport GO:0006826 IEA     iron ion transport GO:0006826 IMP     iron ion transport GO:0006826 ISO     iron ion transport GO:0006826 ISO     iron ion transport GO:0006826 ISS     manganese ion transport GO:0006828 IBA     manganese ion transport GO:0006828 ISO     learning or memory GO:0007611 IEA     learning or memory GO:0007611 ISO     response to iron ion GO:0010039 IEA     response to iron ion GO:0010039 IEP     response to iron ion GO:0010039 ISO     response to iron ion GO:0010039 ISO     response to manganese ion GO:0010042 IEP     response to manganese ion GO:0010042 IMP     response to lead ion GO:0010288 IEP     nickel cation transport GO:0015675 ISO     vanadium ion transport GO:0015676 IEA     vanadium ion transport GO:0015676 ISO     lead ion transport GO:0015692 IEA     lead ion transport GO:0015692 ISO     iron import into cell GO:0033212 IEA     iron import into cell GO:0033212 ISO     iron import into cell GO:0033212 ISO     cellular response to oxidative stress GO:0034599 ISO     iron ion transmembrane transport GO:0034755 IBA     iron ion transmembrane transport GO:0034755 IEA     iron ion transmembrane transport GO:0034755 ISO     copper ion transmembrane transport GO:0035434 IEA     nickel cation transmembrane transport GO:0035444 IEA     response to cadmium ion GO:0046686 IEP     dendrite morphogenesis GO:0048813 IEA     dendrite morphogenesis GO:0048813 ISO     erythrocyte development GO:0048821 IEA     erythrocyte development GO:0048821 ISO     establishment of localization in cell GO:0051649 ISO     multicellular organismal-level iron ion homeostasis GO:0060586 IEA     multicellular organismal-level iron ion homeostasis GO:0060586 ISO     multicellular organismal-level iron ion homeostasis GO:0060586 ISO     cadmium ion transmembrane transport GO:0070574 IEA     cadmium ion transmembrane transport GO:0070574 ISO     cellular response to iron ion GO:0071281 IEP     cellular response to tumor necrosis factor GO:0071356 IEP     manganese ion transmembrane transport GO:0071421 IEA     cellular response to hypoxia GO:0071456 IEP     copper ion import across plasma membrane GO:0098705 IMP     proton transmembrane transport GO:1902600 IEA     positive regulation of cysteine-type endopeptidase activity GO:2001056 ISO Subcellular Localization     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 IEA     mitochondrion GO:0005739 ISO     mitochondrial outer membrane GO:0005741 IEA     lysosome GO:0005764 ISO     lysosomal membrane GO:0005765 IBA     lysosomal membrane GO:0005765 IDA     lysosomal membrane GO:0005765 IEA     lysosomal membrane GO:0005765 ISO     endosome GO:0005768 ISO     early endosome GO:0005769 IEA     early endosome GO:0005769 ISO     early endosome GO:0005769 ISS     late endosome GO:0005770 ISO     vacuole GO:0005773 ISO     trans-Golgi network GO:0005802 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     cell surface GO:0009986 ISO     endosome membrane GO:0010008 IBA     apical plasma membrane GO:0016324 IEA     apical plasma membrane GO:0016324 ISO     cytoplasmic vesicle GO:0031410 ISO     brush border membrane GO:0031526 IEA     brush border membrane GO:0031526 ISO     early endosome membrane GO:0031901 IEA     late endosome membrane GO:0031902 IDA     late endosome membrane GO:0031902 IEA     late endosome membrane GO:0031902 ISO     apical part of cell GO:0045177 IDA     apical part of cell GO:0045177 ISO     basal part of cell GO:0045178 IEA     basal part of cell GO:0045178 ISO     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     recycling endosome GO:0055037 IEA     recycling endosome GO:0055037 ISO     recycling endosome membrane GO:0055038 IEA     paraferritin complex GO:0070826 IEA     paraferritin complex GO:0070826 ISO     extracellular vesicle GO:1903561 IEA     extracellular vesicle GO:1903561 ISO