Gene description for Syt1
Gene name	synaptotagmin I
Gene symbol	Syt1
Other names/aliases	P65
Species	Rattus norvegicus
Database cross references - Syt1
ExoCarta	ExoCarta_25716
Vesiclepedia	VP_25716
Entrez Gene	25716
UniProt	P21707
Syt1 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479

Gene ontology annotations for Syt1

Molecular Function     SNARE binding GO:0000149 IBA     SNARE binding GO:0000149 IDA     SNARE binding GO:0000149 IPI     phosphatidylserine binding GO:0001786 IDA     calcium ion binding GO:0005509 IDA     calcium ion binding GO:0005509 IEA     calcium ion binding GO:0005509 IMP     calcium ion binding GO:0005509 ISO     calcium ion binding GO:0005509 TAS     protein binding GO:0005515 IPI     calmodulin binding GO:0005516 IDA     phospholipid binding GO:0005543 IDA     calcium-dependent phospholipid binding GO:0005544 IBA     calcium-dependent phospholipid binding GO:0005544 IDA     calcium-dependent phospholipid binding GO:0005544 ISO     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IDA     lipid binding GO:0008289 ISO     syntaxin-1 binding GO:0017075 IDA     syntaxin-1 binding GO:0017075 IPI     syntaxin-1 binding GO:0017075 ISO     syntaxin binding GO:0019905 IDA     syntaxin binding GO:0019905 IPI     clathrin binding GO:0030276 IDA     syntaxin-3 binding GO:0030348 IPI     identical protein binding GO:0042802 EXP     identical protein binding GO:0042802 IPI     protein heterodimerization activity GO:0046982 IPI     calcium-dependent protein binding GO:0048306 IDA     calcium-dependent protein binding GO:0048306 ISO     low-density lipoprotein particle receptor binding GO:0050750 ISO     calcium ion sensor activity GO:0061891 EXP     calcium ion sensor activity GO:0061891 IBA     calcium ion sensor activity GO:0061891 ISO     molecular condensate scaffold activity GO:0140693 EXP     molecular condensate scaffold activity GO:0140693 IDA Biological Process     detection of calcium ion GO:0005513 IC     detection of calcium ion GO:0005513 IDA     vesicle fusion GO:0006906 IDA     vesicle fusion GO:0006906 IMP     neurotransmitter secretion GO:0007269 ISO     regulation of dopamine secretion GO:0014059 ISO     vesicle organization GO:0016050 ISO     synaptic vesicle exocytosis GO:0016079 ISO     synaptic vesicle exocytosis GO:0016079 TAS     vesicle-mediated transport GO:0016192 IBA     calcium-ion regulated exocytosis GO:0017156 TAS     regulation of calcium ion-dependent exocytosis GO:0017158 IBA     regulation of calcium ion-dependent exocytosis GO:0017158 IMP     regulation of calcium ion-dependent exocytosis GO:0017158 ISO     cell differentiation GO:0030154 IEA     regulation of vesicle fusion GO:0031338 IMP     positive regulation of vesicle fusion GO:0031340 IDA     positive regulation of dopamine secretion GO:0033603 IMP     positive regulation of calcium ion-dependent exocytosis GO:0045956 IDA     vesicle docking GO:0048278 IDA     vesicle docking GO:0048278 IMP     calcium ion-regulated exocytosis of neurotransmitter GO:0048791 ISO     positive regulation of synaptic transmission GO:0050806 ISO     positive regulation of synaptic transmission GO:0050806 ISS     protein heterooligomerization GO:0051291 IPI     response to calcium ion GO:0051592 IDA     regulation of synaptic transmission, glutamatergic GO:0051966 ISO     regulation of synaptic transmission, glutamatergic GO:0051966 ISS     spontaneous neurotransmitter secretion GO:0061669 ISO     cellular response to calcium ion GO:0071277 IMP     synchronous neurotransmitter secretion GO:0071911 ISO     fast, calcium ion-dependent exocytosis of neurotransmitter GO:0098746 ISO     fast, calcium ion-dependent exocytosis of neurotransmitter GO:0098746 ISS     calcium-dependent activation of synaptic vesicle fusion GO:0099502 IBA     calcium-dependent activation of synaptic vesicle fusion GO:0099502 ISO     membraneless organelle assembly GO:0140694 IDA     positive regulation of calcium ion-dependent exocytosis of neurotransmitter GO:1903235 ISO     positive regulation of calcium ion-dependent exocytosis of neurotransmitter GO:1903235 ISS     regulation of regulated secretory pathway GO:1903305 IMP     positive regulation of dendrite extension GO:1903861 ISO     regulation of synaptic vesicle exocytosis GO:2000300 IBA     regulation of synaptic vesicle exocytosis GO:2000300 IDA Subcellular Localization     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     Golgi apparatus GO:0005794 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     synaptic vesicle GO:0008021 IDA     synaptic vesicle GO:0008021 ISO     postsynaptic density GO:0014069 IDA     secretory granule GO:0030141 IDA     secretory granule GO:0030141 ISO     axon GO:0030424 IBA     axon GO:0030424 ISO     synaptic vesicle membrane GO:0030672 IBA     synaptic vesicle membrane GO:0030672 IDA     synaptic vesicle membrane GO:0030672 IDA     synaptic vesicle membrane GO:0030672 IEA     synaptic vesicle membrane GO:0030672 ISO     synaptic vesicle membrane GO:0030672 TAS     dense core granule GO:0031045 IBA     dense core granule GO:0031045 IDA     dense core granule GO:0031045 ISO     chromaffin granule membrane GO:0042584 IEA     presynaptic membrane GO:0042734 ISO     neuron projection GO:0043005 ISO     terminal bouton GO:0043195 HDA     neuron projection terminus GO:0044306 IDA     postsynaptic membrane GO:0045211 IDA     presynaptic active zone GO:0048786 IDA     excitatory synapse GO:0060076 IDA     exocytic vesicle GO:0070382 IBA     hippocampal mossy fiber to CA3 synapse GO:0098686 IDA     glutamatergic synapse GO:0098978 ISO     presynaptic cytosol GO:0099523 IDA     postsynaptic cytosol GO:0099524 IDA