Gene description for Mep1b
Gene name meprin 1 beta
Gene symbol Mep1b
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Mep1b
ExoCarta ExoCarta_25727
Vesiclepedia VP_25727
Entrez Gene 25727
UniProt P28826  
 Mep1b identified in sEVs derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Mep1b
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    metalloendopeptidase activity GO:0004222 IDA
    metalloendopeptidase activity GO:0004222 IEA
    zinc ion binding GO:0008270 IEA
    protein domain specific binding GO:0019904 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
Biological Process
    proteolysis GO:0006508 IEA
    proteolysis GO:0006508 NAS
    inflammatory response GO:0006954 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 IEA
    membrane GO:0016020 ISO
    meprin A complex GO:0017090 IEA
    meprin A complex GO:0017090 ISO
 Experiment description of studies that identified Mep1b in sEVs
1
Experiment ID 192
MISEV standards
CEM
Biophysical techniques
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Mep1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Os9  
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
2 Os9  
Two-hybrid Rattus norvegicus
Reconstituted Complex Rattus norvegicus
View the network image/svg+xml
 Pathways in which Mep1b is involved
No pathways found





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