Gene description for Apoe
Gene name	apolipoprotein E
Gene symbol	Apoe
Other names/aliases	APOEA
Species	Rattus norvegicus
Database cross references - Apoe
ExoCarta	ExoCarta_25728
Entrez Gene	25728
UniProt	P02650
Apoe identified in exosomes derived from the following tissue/cell type
Hepatocytes	19367702

Gene ontology annotations for Apoe

Molecular Function     protein homodimerization activity GO:0042803 ISO     beta-amyloid binding GO:0001540 ISS     receptor binding GO:0005102 IPI     lipid binding GO:0008289 ISO     low-density lipoprotein particle receptor binding GO:0050750 ISO     tau protein binding GO:0048156 ISO     metal chelating activity GO:0046911 ISO     phospholipid binding GO:0005543 ISO     cholesterol transporter activity GO:0017127 ISO     lipoprotein particle binding GO:0071813 ISO     very-low-density lipoprotein particle receptor binding GO:0070326 ISO     hydroxyapatite binding GO:0046848 IDA     antioxidant activity GO:0016209 ISO     identical protein binding GO:0042802 ISO     heparin binding GO:0008201 ISO     phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 ISO     lipid transporter activity GO:0005319 ISO     cholesterol binding GO:0015485 IBA Biological Process     response to ethanol GO:0045471 IEP     negative regulation of MAP kinase activity GO:0043407 ISO     triglyceride metabolic process GO:0006641 ISO     negative regulation of blood vessel endothelial cell migration GO:0043537 ISO     negative regulation of dendritic spine development GO:0061000 ISO     lipid transport GO:0006869 IDA     regulation of cholesterol transport GO:0032374 IBA     positive regulation of nitric-oxide synthase activity GO:0051000 ISO     negative regulation of inflammatory response GO:0050728 ISO     cGMP-mediated signaling GO:0019934 ISO     negative regulation of platelet activation GO:0010544 ISO     reverse cholesterol transport GO:0043691 ISO     response to retinoic acid GO:0032526 IEP     axon regeneration GO:0031103 ISO     long-chain fatty acid transport GO:0015909 ISO     positive regulation of neuron death GO:1901216 ISO     negative regulation of cholesterol biosynthetic process GO:0045541 ISO     positive regulation of membrane protein ectodomain proteolysis GO:0051044 ISO     negative regulation of presynaptic membrane organization GO:1901630 ISO     cholesterol catabolic process GO:0006707 ISO     positive regulation of lipid biosynthetic process GO:0046889 ISO     response to insulin GO:0032868 IEP     N-methyl-D-aspartate receptor clustering GO:0097114 ISO     positive regulation of neurofibrillary tangle assembly GO:1902998 ISO     alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering GO:0097113 ISO     phospholipid efflux GO:0033700 ISO     vasodilation GO:0042311 ISO     triglyceride catabolic process GO:0019433 IBA     peripheral nervous system axon regeneration GO:0014012 IEP     cellular response to growth factor stimulus GO:0071363 IEP     nitric oxide mediated signal transduction GO:0007263 ISO     negative regulation of cholesterol efflux GO:0090370 ISO     positive regulation of dendritic spine maintenance GO:1902952 ISO     G-protein coupled receptor signaling pathway GO:0007186 ISO     lipid metabolic process GO:0006629 ISO     protein localization GO:0008104 ISO     response to oxidative stress GO:0006979 ISO     maintenance of location in cell GO:0051651 ISO     positive regulation of axon extension GO:0045773 IDA     negative regulation of neuron apoptotic process GO:0043524 IDA     positive regulation of dendritic spine development GO:0060999 ISO     cellular calcium ion homeostasis GO:0006874 ISO     cholesterol metabolic process GO:0008203 ISO     lipoprotein biosynthetic process GO:0042158 ISO     high-density lipoprotein particle remodeling GO:0034375 ISO     regulation of gene expression GO:0010468 ISO     regulation of neuron death GO:1901214 ISO     positive regulation of postsynaptic membrane organization GO:1901628 ISO     negative regulation of lipid biosynthetic process GO:0051055 ISO     low-density lipoprotein particle remodeling GO:0034374 ISO     virion assembly GO:0019068 ISO     cellular response to interleukin-1 GO:0071347 IEP     cholesterol biosynthetic process GO:0006695 IBA     high-density lipoprotein particle clearance GO:0034384 ISO     negative regulation of neuron death GO:1901215 ISO     positive regulation of presynaptic membrane organization GO:1901631 ISO     protein import GO:0017038 ISO     positive regulation of beta-amyloid formation GO:1902004 ISO     positive regulation of catalytic activity GO:0043085 ISO     very-low-density lipoprotein particle remodeling GO:0034372 ISO     very-low-density lipoprotein particle clearance GO:0034447 ISO     lipoprotein catabolic process GO:0042159 ISO     lipoprotein metabolic process GO:0042157 ISO     regulation of beta-amyloid clearance GO:1900221 ISO     response to dietary excess GO:0002021 ISO     negative regulation of blood coagulation GO:0030195 ISO     fatty acid homeostasis GO:0055089 ISO     artery morphogenesis GO:0048844 ISO     aging GO:0007568 IDA     negative regulation of dendritic spine maintenance GO:1902951 ISO     receptor-mediated endocytosis GO:0006898 ISO     negative regulation of endothelial cell proliferation GO:0001937 ISO     cholesterol homeostasis GO:0042632 ISO     cellular response to cholesterol GO:0071397 IEP     positive regulation of lipid transport across blood brain barrier GO:1903002 ISO     high-density lipoprotein particle assembly GO:0034380 ISO     regulation of Cdc42 protein signal transduction GO:0032489 ISO     positive regulation of phospholipid efflux GO:1902995 ISO     cholesterol efflux GO:0033344 ISO     negative regulation of beta-amyloid formation GO:1902430 ISO     positive regulation of cholesterol esterification GO:0010873 ISO     positive regulation of cGMP biosynthetic process GO:0030828 ISO     lipid homeostasis GO:0055088 ISO     negative regulation of phospholipid efflux GO:1902999 ISO     negative regulation of postsynaptic membrane organization GO:1901627 ISO     positive regulation of low-density lipoprotein particle receptor catabolic process GO:0032805 ISO     oligodendrocyte differentiation GO:0048709 IEP     positive regulation by host of viral process GO:0044794 ISO     regulation of tau-protein kinase activity GO:1902947 ISO     neuron projection regeneration GO:0031102 TAS     positive regulation of cholesterol efflux GO:0010875 ISO     chylomicron remnant clearance GO:0034382 ISO     negative regulation of lipid transport across blood brain barrier GO:1903001 ISO     cardiovascular system development GO:0072358 ISO Subcellular Localization     neuronal cell body GO:0043025 IDA     extracellular exosome GO:0070062 ISO     plasma membrane GO:0005886 IDA     early endosome GO:0005769 IDA     extracellular space GO:0005615 ISO     endosome GO:0005768 IDA     membrane GO:0016020 ISO     nuclear envelope GO:0005635 IDA     very-low-density lipoprotein particle GO:0034361 ISO     intermediate-density lipoprotein particle GO:0034363 ISO     Golgi apparatus GO:0005794 ISO     extrinsic component of external side of plasma membrane GO:0031232 IDA     microtubule GO:0005874 IDA     high-density lipoprotein particle GO:0034364 ISO     endoplasmic reticulum GO:0005783 ISO     extracellular matrix GO:0031012 ISO     nucleus GO:0005634 ISO     blood microparticle GO:0072562 ISO     cell surface GO:0009986 IDA     discoidal high-density lipoprotein particle GO:0034365 IDA     low-density lipoprotein particle GO:0034362 ISO     chylomicron GO:0042627 ISO     extracellular vesicle GO:1903561 ISO     late endosome GO:0005770 IDA     dendrite GO:0030425 IDA     cytoplasm GO:0005737 IDA     lysosome GO:0005764 IDA     cell GO:0005623 ISO