Gene description for Apoe
Gene name	apolipoprotein E
Gene symbol	Apoe
Other names/aliases	APOEA
Species	Rattus norvegicus
Database cross references - Apoe
ExoCarta	ExoCarta_25728
Vesiclepedia	VP_25728
Entrez Gene	25728
UniProt	P02650
Apoe identified in sEVs derived from the following tissue/cell type
Hepatocytes	19367702

Gene ontology annotations for Apoe

Molecular Function     amyloid-beta binding GO:0001540 IDA     amyloid-beta binding GO:0001540 IEA     amyloid-beta binding GO:0001540 ISO     amyloid-beta binding GO:0001540 ISS     signaling receptor binding GO:0005102 IPI     signaling receptor binding GO:0005102 ISO     lipid transporter activity GO:0005319 IDA     lipid transporter activity GO:0005319 IEA     lipid transporter activity GO:0005319 ISO     phospholipid binding GO:0005543 IBA     phospholipid binding GO:0005543 IDA     phospholipid binding GO:0005543 IEA     phospholipid binding GO:0005543 ISO     heparin binding GO:0008201 IEA     heparin binding GO:0008201 ISO     heparin binding GO:0008201 ISS     lipid binding GO:0008289 IEA     lipid binding GO:0008289 ISO     antioxidant activity GO:0016209 IEA     antioxidant activity GO:0016209 ISO     enzyme binding GO:0019899 IEA     enzyme binding GO:0019899 ISO     identical protein binding GO:0042802 ISO     identical protein binding GO:0042802 ISS     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     heparan sulfate proteoglycan binding GO:0043395 IEA     heparan sulfate proteoglycan binding GO:0043395 ISO     heparan sulfate proteoglycan binding GO:0043395 ISS     protein-containing complex binding GO:0044877 IEA     protein-containing complex binding GO:0044877 ISO     hydroxyapatite binding GO:0046848 IDA     metal chelating activity GO:0046911 IEA     metal chelating activity GO:0046911 ISO     protein dimerization activity GO:0046983 ISO     receptor ligand activity GO:0048018 IEA     receptor ligand activity GO:0048018 ISO     tau protein binding GO:0048156 IEA     tau protein binding GO:0048156 ISO     low-density lipoprotein particle receptor binding GO:0050750 IEA     low-density lipoprotein particle receptor binding GO:0050750 ISO     low-density lipoprotein particle receptor binding GO:0050750 ISS     phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 IBA     phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 IEA     phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 ISO     very-low-density lipoprotein particle receptor binding GO:0070326 IEA     very-low-density lipoprotein particle receptor binding GO:0070326 ISO     lipoprotein particle binding GO:0071813 ISO     cholesterol transfer activity GO:0120020 IBA     cholesterol transfer activity GO:0120020 ISO Biological Process     negative regulation of endothelial cell proliferation GO:0001937 IEA     negative regulation of endothelial cell proliferation GO:0001937 ISO     response to dietary excess GO:0002021 ISO     lipid metabolic process GO:0006629 ISO     triglyceride metabolic process GO:0006641 IEA     triglyceride metabolic process GO:0006641 ISO     cholesterol catabolic process GO:0006707 ISO     lipid transport GO:0006869 IDA     lipid transport GO:0006869 IEA     intracellular calcium ion homeostasis GO:0006874 ISO     receptor-mediated endocytosis GO:0006898 IEA     receptor-mediated endocytosis GO:0006898 ISO     response to oxidative stress GO:0006979 ISO     G protein-coupled receptor signaling pathway GO:0007186 IEA     G protein-coupled receptor signaling pathway GO:0007186 ISO     long-term memory GO:0007616 IEA     long-term memory GO:0007616 ISO     protein localization GO:0008104 ISO     cholesterol metabolic process GO:0008203 IBA     cholesterol metabolic process GO:0008203 IEA     cholesterol metabolic process GO:0008203 ISO     cholesterol metabolic process GO:0008203 ISO     response to zinc ion GO:0010043 IEP     gene expression GO:0010467 ISO     regulation of gene expression GO:0010468 ISO     negative regulation of platelet activation GO:0010544 IEA     negative regulation of platelet activation GO:0010544 ISO     negative regulation of endothelial cell migration GO:0010596 ISO     negative regulation of gene expression GO:0010629 ISO     positive regulation of cholesterol efflux GO:0010875 IEA     positive regulation of cholesterol efflux GO:0010875 ISO     lipid transport involved in lipid storage GO:0010877 ISO     positive regulation of neuron projection development GO:0010976 IEA     positive regulation of neuron projection development GO:0010976 ISO     negative regulation of neuron projection development GO:0010977 IEA     negative regulation of neuron projection development GO:0010977 ISO     peripheral nervous system axon regeneration GO:0014012 IEP     long-chain fatty acid transport GO:0015909 IEA     long-chain fatty acid transport GO:0015909 ISO     protein import GO:0017038 IEA     protein import GO:0017038 ISO     virion assembly GO:0019068 IEA     virion assembly GO:0019068 ISO     negative regulation of blood coagulation GO:0030195 ISO     neuron projection regeneration GO:0031102 TAS     axon regeneration GO:0031103 ISO     neuron projection development GO:0031175 IEA     neuron projection development GO:0031175 ISO     melanosome organization GO:0032438 IEA     melanosome organization GO:0032438 ISO     melanosome organization GO:0032438 ISS     regulation of Cdc42 protein signal transduction GO:0032489 IEA     regulation of Cdc42 protein signal transduction GO:0032489 ISO     response to retinoic acid GO:0032526 IEP     positive regulation of low-density lipoprotein particle receptor catabolic process GO:0032805 IEA     positive regulation of low-density lipoprotein particle receptor catabolic process GO:0032805 ISO     response to insulin GO:0032868 IEP     cholesterol efflux GO:0033344 IBA     cholesterol efflux GO:0033344 IEA     cholesterol efflux GO:0033344 ISO     cholesterol efflux GO:0033344 ISO     cholesterol efflux GO:0033344 ISS     phospholipid efflux GO:0033700 IBA     phospholipid efflux GO:0033700 IEA     phospholipid efflux GO:0033700 ISO     very-low-density lipoprotein particle remodeling GO:0034372 IEA     very-low-density lipoprotein particle remodeling GO:0034372 ISO     low-density lipoprotein particle remodeling GO:0034374 ISO     high-density lipoprotein particle remodeling GO:0034375 IEA     high-density lipoprotein particle remodeling GO:0034375 ISO     high-density lipoprotein particle assembly GO:0034380 IEA     high-density lipoprotein particle assembly GO:0034380 ISO     high-density lipoprotein particle assembly GO:0034380 ISS     chylomicron remnant clearance GO:0034382 IEA     chylomicron remnant clearance GO:0034382 ISO     chylomicron remnant clearance GO:0034382 ISS     high-density lipoprotein particle clearance GO:0034384 IEA     high-density lipoprotein particle clearance GO:0034384 ISO     very-low-density lipoprotein particle clearance GO:0034447 IEA     very-low-density lipoprotein particle clearance GO:0034447 ISO     very-low-density lipoprotein particle clearance GO:0034447 ISS     response to tumor necrosis factor GO:0034612 IEP     locomotory exploration behavior GO:0035641 IEA     locomotory exploration behavior GO:0035641 ISO     nitric oxide-cGMP-mediated signaling GO:0038060 IEA     nitric oxide-cGMP-mediated signaling GO:0038060 ISO     lipoprotein metabolic process GO:0042157 IDA     lipoprotein metabolic process GO:0042157 IEA     lipoprotein metabolic process GO:0042157 ISO     lipoprotein biosynthetic process GO:0042158 IEA     lipoprotein biosynthetic process GO:0042158 ISO     lipoprotein biosynthetic process GO:0042158 ISO     lipoprotein biosynthetic process GO:0042158 ISS     lipoprotein catabolic process GO:0042159 ISO     vasodilation GO:0042311 ISO     cholesterol homeostasis GO:0042632 IEA     cholesterol homeostasis GO:0042632 ISO     cholesterol homeostasis GO:0042632 ISO     regulation of apoptotic process GO:0042981 ISO     amyloid precursor protein metabolic process GO:0042982 IEA     amyloid precursor protein metabolic process GO:0042982 ISO     regulation of protein-containing complex assembly GO:0043254 IEA     regulation of protein-containing complex assembly GO:0043254 ISO     negative regulation of MAP kinase activity GO:0043407 ISO     negative regulation of blood vessel endothelial cell migration GO:0043537 IEA     negative regulation of blood vessel endothelial cell migration GO:0043537 ISO     reverse cholesterol transport GO:0043691 IEA     reverse cholesterol transport GO:0043691 ISO     positive regulation by host of viral process GO:0044794 IEA     positive regulation by host of viral process GO:0044794 ISO     regulation of innate immune response GO:0045088 ISO     positive regulation of nitric oxide biosynthetic process GO:0045429 IEA     positive regulation of nitric oxide biosynthetic process GO:0045429 ISO     response to ethanol GO:0045471 IEP     negative regulation of cholesterol biosynthetic process GO:0045541 IDA     negative regulation of cholesterol biosynthetic process GO:0045541 IEA     negative regulation of cholesterol biosynthetic process GO:0045541 ISO     positive regulation of axon extension GO:0045773 IDA     positive regulation of endocytosis GO:0045807 IEA     positive regulation of endocytosis GO:0045807 ISO     positive regulation of DNA-templated transcription GO:0045893 IEA     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of lipid biosynthetic process GO:0046889 IEA     positive regulation of lipid biosynthetic process GO:0046889 ISO     negative regulation of smooth muscle cell proliferation GO:0048662 ISO     oligodendrocyte differentiation GO:0048709 IEP     artery morphogenesis GO:0048844 ISO     negative regulation of protein secretion GO:0050709 IEA     negative regulation of protein secretion GO:0050709 ISO     negative regulation of inflammatory response GO:0050728 IEA     negative regulation of inflammatory response GO:0050728 ISO     regulation of synapse organization GO:0050807 ISO     positive regulation of membrane protein ectodomain proteolysis GO:0051044 IEA     positive regulation of membrane protein ectodomain proteolysis GO:0051044 ISO     negative regulation of lipid biosynthetic process GO:0051055 ISO     regulation of protein metabolic process GO:0051246 ISO     negative regulation of protein metabolic process GO:0051248 ISO     maintenance of location in cell GO:0051651 ISO     lipid homeostasis GO:0055088 ISO     fatty acid homeostasis GO:0055089 IEA     fatty acid homeostasis GO:0055089 ISO     acylglycerol homeostasis GO:0055090 IBA     positive regulation of dendritic spine development GO:0060999 IEA     positive regulation of dendritic spine development GO:0060999 ISO     negative regulation of dendritic spine development GO:0061000 ISO     regulation of proteasomal protein catabolic process GO:0061136 IEA     regulation of proteasomal protein catabolic process GO:0061136 ISO     response to caloric restriction GO:0061771 IEA     response to caloric restriction GO:0061771 ISO     triglyceride homeostasis GO:0070328 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     cellular response to interleukin-1 GO:0071347 IEP     cellular response to ethanol GO:0071361 IEP     cellular response to growth factor stimulus GO:0071363 IEP     cellular response to cholesterol GO:0071397 IEP     cellular response to lipoprotein particle stimulus GO:0071402 IEA     cellular response to lipoprotein particle stimulus GO:0071402 ISO     triglyceride-rich lipoprotein particle clearance GO:0071830 ISO     triglyceride-rich lipoprotein particle clearance GO:0071830 ISS     intermediate-density lipoprotein particle clearance GO:0071831 IEA     intermediate-density lipoprotein particle clearance GO:0071831 ISO     intermediate-density lipoprotein particle clearance GO:0071831 ISS     circulatory system development GO:0072359 ISO     negative regulation of canonical Wnt signaling pathway GO:0090090 IEA     negative regulation of canonical Wnt signaling pathway GO:0090090 ISO     regulation of cholesterol metabolic process GO:0090181 ISO     positive regulation of cholesterol metabolic process GO:0090205 IEA     positive regulation of cholesterol metabolic process GO:0090205 ISO     regulation of triglyceride metabolic process GO:0090207 IDA     negative regulation of triglyceride metabolic process GO:0090209 ISO     negative regulation of cholesterol efflux GO:0090370 ISO     regulation of plasma lipoprotein particle levels GO:0097006 ISO     AMPA glutamate receptor clustering GO:0097113 IEA     AMPA glutamate receptor clustering GO:0097113 ISO     NMDA glutamate receptor clustering GO:0097114 IEA     NMDA glutamate receptor clustering GO:0097114 ISO     cellular oxidant detoxification GO:0098869 IEA     positive regulation of lipoprotein transport GO:0140077 IEA     positive regulation of lipoprotein transport GO:0140077 ISO     regulation of amyloid-beta clearance GO:1900221 IEA     regulation of amyloid-beta clearance GO:1900221 ISO     positive regulation of amyloid-beta clearance GO:1900223 ISO     positive regulation of amyloid-beta clearance GO:1900223 ISS     negative regulation of long-term synaptic potentiation GO:1900272 IEA     negative regulation of long-term synaptic potentiation GO:1900272 ISO     negative regulation of postsynaptic membrane organization GO:1901627 ISO     positive regulation of presynaptic membrane organization GO:1901631 ISO     positive regulation of amyloid-beta formation GO:1902004 ISO     negative regulation of amyloid-beta formation GO:1902430 IEA     negative regulation of amyloid-beta formation GO:1902430 ISO     negative regulation of dendritic spine maintenance GO:1902951 ISO     positive regulation of dendritic spine maintenance GO:1902952 IEA     positive regulation of dendritic spine maintenance GO:1902952 ISO     regulation of amyloid precursor protein catabolic process GO:1902991 ISO     positive regulation of phospholipid efflux GO:1902995 IEA     positive regulation of phospholipid efflux GO:1902995 ISO     positive regulation of neurofibrillary tangle assembly GO:1902998 ISO     negative regulation of phospholipid efflux GO:1902999 ISO     negative regulation of lipid transport across blood-brain barrier GO:1903001 ISO     positive regulation of lipid transport across blood-brain barrier GO:1903002 IEA     positive regulation of lipid transport across blood-brain barrier GO:1903002 ISO     response to D-galactosamine GO:1904421 IEP     regulation of cellular response to very-low-density lipoprotein particle stimulus GO:1905890 IEA     regulation of cellular response to very-low-density lipoprotein particle stimulus GO:1905890 ISO     regulation of amyloid fibril formation GO:1905906 IEA     regulation of amyloid fibril formation GO:1905906 ISO     negative regulation of amyloid fibril formation GO:1905907 ISO     negative regulation of amyloid fibril formation GO:1905907 ISS     positive regulation of CoA-transferase activity GO:1905920 ISO     regulation of behavioral fear response GO:2000822 IEA     regulation of behavioral fear response GO:2000822 ISO Subcellular Localization     extracellular region GO:0005576 ISO     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     extracellular space GO:0005615 ISO     nuclear envelope GO:0005635 IDA     endosome GO:0005768 IDA     early endosome GO:0005769 IDA     late endosome GO:0005770 IDA     multivesicular body GO:0005771 IEA     endoplasmic reticulum GO:0005783 IEA     endoplasmic reticulum GO:0005783 ISO     Golgi apparatus GO:0005794 IEA     Golgi apparatus GO:0005794 ISO     microtubule GO:0005874 IDA     plasma membrane GO:0005886 IEA     cell surface GO:0009986 IDA     dendrite GO:0030425 IDA     extracellular matrix GO:0031012 IEA     extracellular matrix GO:0031012 ISO     extracellular matrix GO:0031012 ISS     extrinsic component of external side of plasma membrane GO:0031232 IDA     chylomicron remnant GO:0034360 IEA     chylomicron remnant GO:0034360 ISO     very-low-density lipoprotein particle GO:0034361 IBA     very-low-density lipoprotein particle GO:0034361 IDA     very-low-density lipoprotein particle GO:0034361 IEA     very-low-density lipoprotein particle GO:0034361 ISO     low-density lipoprotein particle GO:0034362 IBA     low-density lipoprotein particle GO:0034362 IDA     low-density lipoprotein particle GO:0034362 IEA     low-density lipoprotein particle GO:0034362 ISO     intermediate-density lipoprotein particle GO:0034363 IDA     intermediate-density lipoprotein particle GO:0034363 IEA     intermediate-density lipoprotein particle GO:0034363 ISO     high-density lipoprotein particle GO:0034364 IBA     high-density lipoprotein particle GO:0034364 IDA     high-density lipoprotein particle GO:0034364 IEA     high-density lipoprotein particle GO:0034364 ISO     discoidal high-density lipoprotein particle GO:0034365 IDA     melanosome GO:0042470 IEA     melanosome GO:0042470 ISO     chylomicron GO:0042627 IBA     chylomicron GO:0042627 IDA     chylomicron GO:0042627 IEA     chylomicron GO:0042627 ISO     neuronal cell body GO:0043025 IDA     synaptic cleft GO:0043083 IEA     synaptic cleft GO:0043083 ISO     extracellular exosome GO:0070062 IEA     extracellular exosome GO:0070062 ISO     extracellular exosome GO:0070062 ISS     multivesicular body, internal vesicle GO:0097487 IEA     multivesicular body, internal vesicle GO:0097487 ISO     multivesicular body, internal vesicle GO:0097487 ISS     glutamatergic synapse GO:0098978 IEA     glutamatergic synapse GO:0098978 ISO     extracellular vesicle GO:1903561 IBA     lipoprotein particle GO:1990777 ISO