Gene description for S100b
Gene name S100 calcium binding protein B
Gene symbol S100b
Other names/aliases S100P
Species Rattus norvegicus
 Database cross references - S100b
ExoCarta ExoCarta_25742
Vesiclepedia VP_25742
Entrez Gene 25742
UniProt P04631  
 S100b identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for S100b
Molecular Function
    signaling receptor binding GO:0005102 IPI
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IDA
    calcium ion binding GO:0005509 IEA
    calcium ion binding GO:0005509 ISO
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    zinc ion binding GO:0008270 IEA
    zinc ion binding GO:0008270 ISO
    zinc ion binding GO:0008270 ISS
    identical protein binding GO:0042802 IPI
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    S100 protein binding GO:0044548 IBA
    S100 protein binding GO:0044548 ISO
    tau protein binding GO:0048156 ISS
    calcium-dependent protein binding GO:0048306 IBA
    calcium-dependent protein binding GO:0048306 ISO
    RAGE receptor binding GO:0050786 IBA
    RAGE receptor binding GO:0050786 IPI
    RAGE receptor binding GO:0050786 ISO
Biological Process
    cell adhesion GO:0007155 IEA
    learning or memory GO:0007611 ISO
    learning or memory GO:0007611 ISS
    memory GO:0007613 ISO
    positive regulation of cell population proliferation GO:0008284 IBA
    positive regulation of cell population proliferation GO:0008284 IMP
    regulation of cell shape GO:0008360 IMP
    positive regulation of myelination GO:0031643 IMP
    positive regulation of apoptotic process GO:0043065 IMP
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    positive regulation of neuron differentiation GO:0045666 ISO
    regulation of neuronal synaptic plasticity GO:0048168 ISO
    astrocyte differentiation GO:0048708 IEP
    positive regulation of synaptic transmission GO:0050806 IMP
    response to glucocorticoid GO:0051384 IEP
    response to methylmercury GO:0051597 IEP
    long-term synaptic potentiation GO:0060291 IEP
    cellular response to hypoxia GO:0071456 IEP
    response to anesthetic GO:0072347 IEP
    sympathetic neuron projection extension GO:0097490 ISO
    sympathetic neuron projection extension GO:0097490 ISS
    neuron projection extension GO:1990138 ISO
    adaptive thermogenesis GO:1990845 ISO
    adaptive thermogenesis GO:1990845 ISS
    negative regulation of skeletal muscle cell differentiation GO:2001015 IMP
Subcellular Localization
    ruffle GO:0001726 ISO
    extracellular region GO:0005576 IEA
    extracellular region GO:0005576 ISO
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 ISO
    neuronal cell body GO:0043025 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified S100b in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for S100b
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ager  
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml



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