Gene description for S100b
Gene name S100 calcium binding protein B
Gene symbol S100b
Other names/aliases S100P
Species Rattus norvegicus
 Database cross references - S100b
ExoCarta ExoCarta_25742
Entrez Gene 25742
UniProt P04631  
 S100b identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for S100b
Molecular Function
    receptor binding GO:0005102 IPI
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    RAGE receptor binding GO:0050786 ISO
    S100 protein binding GO:0044548 ISO
    calcium-dependent protein binding GO:0048306 ISO
    identical protein binding GO:0042802 ISO
    tau protein binding GO:0048156 ISS
    protein homodimerization activity GO:0042803 ISO
    zinc ion binding GO:0008270 ISS
Biological Process
    positive regulation of cell proliferation GO:0008284 IMP
    regulation of neuronal synaptic plasticity GO:0048168 ISO
    learning or memory GO:0007611 ISS
    regulation of cell shape GO:0008360 IMP
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISO
    response to glucocorticoid GO:0051384 IEP
    response to methylmercury GO:0051597 IEP
    astrocyte differentiation GO:0048708 IEP
    memory GO:0007613 ISO
    negative regulation of skeletal muscle cell differentiation GO:2001015 IMP
    positive regulation of apoptotic process GO:0043065 IMP
    cellular response to hypoxia GO:0071456 IEP
    positive regulation of synaptic transmission GO:0050806 IMP
    long-term synaptic potentiation GO:0060291 IEP
Subcellular Localization
    neuronal cell body GO:0043025 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISS
    ruffle GO:0001726 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified S100b in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for S100b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here